Protein Alignment CG6793 and LAMA2

DIOPT Version :10

• Sequence 1: NP_648541.1
• Gene: CG6793 / 39369
• FlyBaseID: FBgn0036242
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_000417.3
• Gene: LAMA2 / 3908
• HGNCID: 6482
• Length: 3122
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 105/511 - (20%)
• Similarity: 202/511 - (39%)
• Gaps: 140/511 - (27%)

  Fly   138 ARLQSEVMRSVNVQREVQAEFARVNQQQKELDRKIFQEQVLRGFEE---------AQQRHKEQCQ 193
            |||:..|| |:|:...:.|.:                 ::|.|.|.         :.||..|:..
Human  1587 ARLEQMVM-SINLTGPLPAPY-----------------KMLYGLENMTQELKHLLSPQRAPERLI 1633

  Fly   194 QLSE--------HKKELL----HLIAERER-----ERQATKAKELEEALKERER-----NERMMK 236
            ||:|        ...|||    .:.|:.|:     ||..|:||.|.|.:||..|     ||:.:|
Human  1634 QLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIK 1698

  Fly   237 -------DQQAKEKELQAAKQRKKKDEALASLVMSDQRQKRLQMLEEM---EQVRCD-------- 283
                   ..:|.|:.|:..  :|:.|:.:..|     |:|.|:..:|:   |.|..:
Human  1699 LNETLGTRDEAFERNLEGL--QKEIDQMIKEL-----RRKNLETQKEIAEDELVAAEALLKKVKK 1756

  Fly   284 IHNKAKGDLEQLKRDRAKERVDQRIRRNE--KLAKELAPRLHYSAREDEERHKRQLEEMRKVHSA 346
            :..:::|:.|::::|..::..|.:.:.::  .|.:|...::            |:...:..|:..
Human  1757 LFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKI------------REANRLFAVNQK 1809

  Fly   347 EQAKWRKSKEQAKNARLAVQREEEGLAKKSRQKAEEDRRLAEE-QRLQNHQTNVQFKRQQREEHI 410
            ......|.||..::.:    |:.|...|:.....:|..|||:| ..:.::..::|.|.....|.:
Human  1810 NMTALEKKKEAVESGK----RQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEEL 1870

  Fly   411 -QRIRKLRQDL-DEQVKKRIEEETRPGTNYNREAQLEELREDAFFFDYARQLMDEAQAKGCPLKP 473
             .:|..|.|:: |.::.:::.:         .|:...:|.:.:...|   .::|||:........
Human  1871 NDKIDDLSQEIKDRKLAEKVSQ---------AESHAAQLNDSSAVLD---GILDEAKNISFNATA 1923

  Fly   474 FIRAVGQYKN----DNRIGAEIRIPRHMITRLPMGRRTQGDSQAEGKEKPSDKQEPNSEKLSKEE 534
            ..:|....|:    ..::..|.:...|..|:|..|.|......|:|..:.|.:....::||:.:.
Human  1924 AFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDV 1988

  Fly   535 K----------------------LLRQKIDENLKKIEAL------VLQEGKDKDDQ 562
            |                      ||| .:::.|.|:.|:      .||..|||..|
Human  1989 KENEDHLNGLKTRIENADARNGDLLR-TLNDTLGKLSAIPNDTAAKLQAVKDKARQ 2043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6793	NP_648541.1	PTZ00121	<33..433	CDD:173412	73/348 (21%)
LAMA2	NP_000417.3	LamNT	37..285	CDD:214532
		EGF_Lam	287..334	CDD:238012
		Laminin_EGF	414..471	CDD:395007
		Laminin_EGF	469..515	CDD:395007
		LamB	578..710	CDD:214597
		EGF_Lam	756..805	CDD:238012
		Laminin_EGF	807..862	CDD:395007
		EGF_Lam	864..916	CDD:238012
		EGF_Lam	917..965	CDD:238012
		EGF_Lam	967..1011	CDD:214543
		EGF_Lam	1014..1057	CDD:214543
		Laminin_EGF	1060..1108	CDD:395007
		Laminin_EGF	1106..1163	CDD:395007
		LamB	1229..1364	CDD:214597
		Laminin_EGF	1420..1466	CDD:395007
		Laminin_EGF	1469..1524	CDD:395007
		EGF_Lam	1527..1574	CDD:238012
		Domain II and I	1574..2144		105/511 (21%)
		Laminin_I	1593..1852	CDD:310534	63/299 (21%)
		SMC_prok_B	1718..>2077	CDD:274008	67/360 (19%)
		Laminin_II	2037..2173	CDD:368703	4/7 (57%)
		Laminin_G_1	2174..2314	CDD:395008
		Laminin_G_1	2368..2507	CDD:395008
		Laminin_G_1	2554..2695	CDD:395008
		Laminin_G_1	2793..2921	CDD:395008
		LamG	2941..3093	CDD:238058
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3043..3063