DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rols and TANC1

DIOPT Version :9

Sequence 1:	NP_729778.1	Gene:	rols / 39368	FlyBaseID:	FBgn0041096	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	XP_011510350.1	Gene:	TANC1 / 85461	HGNCID:	29364	Length:	1885	Species:	Homo sapiens

Alignment Length:	1388	Identity:	534/1388 - (38%)
Similarity:	750/1388 - (54%)	Gaps:	193/1388 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   585 RDNQPEGKESNALNTSTCSDSAVTRRRRKNVSNHNLKTSARHGASSENRLNRLS-LAGTSV-YAG 647
            :..:|:..|:.|.|..:||.:|                        :..|.||. |.|..: .|.
Human   138 KPTEPDEHEAKADNEPSCSPAA------------------------QELLTRLGFLLGEGIPSAT 178

  Fly   648 HLSSLVFGKIKSLWSVNSSNSSEAG-LNQLAGSDAIDHHSSFLNEKLQKDQLHARLGLLLNDPGS 711
            |::  :..|.:::.:..|...|... |.....|.:.|...|.||..:.|
Human   179 HIT--IEDKNETMCTALSQGISPCSTLTSSTASPSTDSPCSTLNSCVSK---------------- 225

  Fly   712 NGNSSSSGSGCEPISAHSTTSTTSSSGVGAASTT------------------------------- 745
               ::::.|.||.||:.|:|..:..||:.|..|:
Human   226 ---TAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRSGSSLEWNKDGNLRLGVQKGVLHD 287

  Fly   746 -------------TSGSSQNVSPEQTLASGAGMLSGSQLS-----------VATSHGVKEDALSL 786
                         |:||:::..|:...::|.|.:..||.|           .|||....||...|
Human   288 RRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYSQGSSSLIMPRPNSVAATSSTKLEDLSYL 352

  Fly   787 CGKFKAGCSMLHVYEALPSKSRKGNVRRSTRGQQGSSSSASAASAVGSRVTASSLAAVQLALKPL 851
            .|:                  |...:|.|.| ....:::...|..|.:|.  :......:.||||
Human   353 DGQ------------------RNAPLRTSIR-LPWHNTAGGRAQEVKARF--APYKPQDILLKPL 396

  Fly   852 FFEVPLQEPDPPYVGRQWLVQQLSNILLGT---ETRVVLINGQPGTGKTAFCLQLVEYSCFGRRQ 913
            .||||....|..:|||.||..|:...|..|   |.|..::.|..|.||||...:||..||.|.|.
Human   397 LFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGKTAIISKLVALSCHGSRM 461

  Fly   914 MQ------------DDP--DGIYSQL------------------QLGAHCERMRG-----LASHM 941
            .|            .||  |..::.|                  .:.|..:|.|.     |||.:
Human   462 RQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPLGSISAENQRPREDAVKYLASKV 526

  Fly   942 VGYHFCQADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSEPHLQDILSVRECIADAERVMKL 1006
            |.||:||||...||.||:||||:||.||::.||.||||.|:.||.||.:||:|.|:.|.....|.
Human   527 VAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQLQSMLSLRSCVQDPVAAFKR 591

  Fly  1007 AILEPLAHLHRAGKIPAKVAVIVVDALCEAEYHRPDHGHTIASFLAQLTPHFPAWLKLVATVRTQ 1071
            .:||||.:|....|||.:..:|::|.|.|||:|:||:|.|::||:.::...|||||||:.|||..
Human   592 GVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFHKPDYGDTLSSFITKIISKFPAWLKLIVTVRAN 656

  Fly  1072 MLELVKAPSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIRMNIGGGGGQNSQSGSQPQT--- 1133
            ..|::.|..:.:|:||.:..::.:..|:..|:..|:..|.:|..||       |.:|....|
Human   657 FQEIISALPFVKLSLDDFPDNKDIHSDLHAYVQHRVHSSQDILSNI-------SLNGKADATLIG 714

  Fly  1134 KFVSHLQSLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSLAQIFLLHFNLRFPTARSFEQAA 1198
            |..|||...|.||.||.||.|||..||.|||||:||||:||||::::||..|::|.|..:||:|.
Human   715 KVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYKVVPVSLSELYLLQCNMKFMTQSAFERAL 779

  Fly  1199 PILNICLAALYPLTLDEIYYSMEALSHGREALSWPDFMQRFKLLDGFLIKRLDNTYMFFHSSLRE 1263
            ||||:.||:|:|:|.::|:.::.| .|.:....|.||.||...|..|||||.|.|.||.|.|.||
Human   780 PILNVALASLHPMTDEQIFQAINA-GHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFRE 843

  Fly  1264 WLMRRDEGESNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLELGHHMLKAHLYGGTS-LTLLSPR 1327
            ||:.|.:||:..|||:.|.|||.:||..||.:..|:.|.|:|||||:||||::.|.| .|.:|..
Human   844 WLVWRADGENTAFLCEPRNGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSS 908

  Fly  1328 DLQSYWLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASPNHRTDYMGGAPILCIAAHEGILP 1392
            .||:.|:..:.:.:|::|.:|||:|:||:|||||::|.||:.|:||:.:..|||||:.:|.|...
Human   909 HLQALWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEE 973

  Fly  1393 MVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHL 1457
            :|:|||||||.:..|:..|.|.|..||..||..:|..|...|..:..||...:|||||:|..||.
Human   974 VVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHG 1038

  Fly  1458 SVVKYLLACDWSPRPHSQDVTR-SVALQQALIGAAAQAHCKILEDLLDLNETEFDLDVNGMEPSS 1521
            .:::|||.|:|||.|......| |.||||||..||:..|..:::.||.: |.|.:::|||.:...
Human  1039 DILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGM-EKEHEVEVNGTDTLW 1102

  Fly  1522 GELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEPLG 1586
            ||.||||||..|.::|..:||..||.:...||:|...|:.|.::|||.:|..||:||.  |..|.
Human  1103 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGC--DVNLS 1165

  Fly  1587 QTR-KTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHH 1650
            ..: :||||:||.||||..|:.||::||...:.|.||.:|||||||:||.|..:.|:|.|.....
Human  1166 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQ 1230

  Fly  1651 EDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGAKLG 1715
            .|.||||.|||||:.|.|..|:|::|:|..:||:|..|||||||||.|||...|...||||||||
Human  1231 TDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1295

  Fly  1716 PTTWSMAMGKPEILVILLNKLLEDGNVLYRKNRFQEAAHRYQYALRKISGLEQLLERNAIFAQLR 1780
            ...|:||..||:||:|||.||:|:|||:|:|.:.:|||.||||||||.. .|...|....|.:||
Human  1296 NAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFP-REGFGEDMRPFNELR 1359

  Fly  1781 TNLLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMELGALNEALVDANEAMQQA 1845
            .:|.||||||:||.|:...:.:.|::|:..||.|||.:||||:|:........||.|..||::
Human  1360 VSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVK-- 1422

  Fly  1846 AQSGVLC----EVVEVLKRIQTE 1864
                 ||    ||..:|.|::.|
Human  1423 -----LCPTNQEVKRLLARVEEE 1440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rols	NP_729778.1	zf-RING_5	327..364	CDD:291308
		Ank_5	1363..1418	CDD:290568	25/54 (46%)
		ANK	1378..1503	CDD:238125	55/125 (44%)
		ANK repeat	1382..1408	CDD:293786	12/25 (48%)
		ANK repeat	1410..1441	CDD:293786	10/30 (33%)
		Ank_2	1415..1552	CDD:289560	58/137 (42%)
		ANK	1486..1609	CDD:238125	52/123 (42%)
		ANK repeat	1486..1518	CDD:293786	12/31 (39%)
		ANK repeat	1521..1552	CDD:293786	14/30 (47%)
		Ank_2	1526..1619	CDD:289560	41/93 (44%)
		ANK	1549..1675	CDD:238125	60/126 (48%)
		ANK repeat	1554..1586	CDD:293786	12/31 (39%)
		ANK repeat	1591..1619	CDD:293786	15/27 (56%)
		Ank_2	1593..1685	CDD:289560	47/91 (52%)
		ANK repeat	1621..1652	CDD:293786	15/30 (50%)
		ANK repeat	1654..1685	CDD:293786	17/30 (57%)
		Ank_2	1659..1735	CDD:289560	45/75 (60%)
		ANK repeat	1687..1712	CDD:293786	16/24 (67%)
		TPR_11	1736..1812	CDD:290150	35/75 (47%)
		TPR repeat	1736..1768	CDD:276809	18/31 (58%)
		TPR repeat	1773..1810	CDD:276809	15/36 (42%)
		TPR_11	1783..1843	CDD:290150	27/59 (46%)
		TPR repeat	1815..1843	CDD:276809	12/27 (44%)
TANC1	XP_011510350.1	AAA_16	409..>451	CDD:289934	16/41 (39%)
		ANK	936..1045	CDD:238125	49/108 (45%)
		Ank_4	962..1011	CDD:290365	22/48 (46%)
		ANK repeat	963..989	CDD:293786	12/25 (48%)
		ANK	986..1189	CDD:238125	87/205 (42%)
		ANK repeat	991..1022	CDD:293786	10/30 (33%)
		Ank_2	996..1133	CDD:289560	58/137 (42%)
		Ank_2	1076..1166	CDD:289560	37/92 (40%)
		ANK repeat	1103..1133	CDD:293786	14/29 (48%)
		ANK	1132..1255	CDD:238125	60/124 (48%)
		ANK repeat	1139..1166	CDD:293786	12/28 (43%)
		Ank_2	1140..1232	CDD:289560	43/93 (46%)
		ANK repeat	1169..1199	CDD:293786	15/29 (52%)
		ANK	1199..1313	CDD:238125	64/113 (57%)
		ANK repeat	1201..1232	CDD:293786	15/30 (50%)
		Ank_2	1206..1294	CDD:289560	49/87 (56%)
		ANK repeat	1234..1265	CDD:293786	17/30 (57%)
		ANK repeat	1267..1292	CDD:293786	16/24 (67%)
		TPR_11	1314..1391	CDD:290150	36/77 (47%)
		TPR repeat	1316..1341	CDD:276809	15/24 (63%)
		TPR repeat	1359..1389	CDD:276809	13/29 (45%)
		TPR_11	1362..1425	CDD:290150	28/69 (41%)
		TPR repeat	1394..1422	CDD:276809	12/27 (44%)
		TPR_14	1395..1437	CDD:290164	16/48 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	441	1.000	Domainoid score	I552
eggNOG	1	0.900	-	-		E33208_3BH8T
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	871	1.000	Inparanoid score	I418
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073736at2759
OrthoFinder	1	1.000	-	-		FOG0003165
OrthoInspector	1	1.000	-	-		otm41841
orthoMCL	1	0.900	-	-		OOG6_105209
Panther	1	1.100	-	-	O	PTHR24166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1834
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830