DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rols and Ankrd55

DIOPT Version :9

Sequence 1:	NP_729778.1	Gene:	rols / 39368	FlyBaseID:	FBgn0041096	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_084174.2	Gene:	Ankrd55 / 77318	MGIID:	1924568	Length:	626	Species:	Mus musculus

Alignment Length:	475	Identity:	114/475 - (24%)
Similarity:	173/475 - (36%)	Gaps:	140/475 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1509 EFDLDVNGMEPSSGEL-ALTAAAR-----------HGC-----------IDVVGILLSRGAQIDA 1550
            |.||.:.....|:|:: :||:..|           .||           :|.|.:||..||.|:.
Mouse    24 EVDLAMVYQAASNGDVNSLTSVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINT 88

  Fly  1551 RNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQR 1615
            ::..|.::|.||...|.......||:.||..:.| .:..:.||..|..|..:.|:.:||.:.:..
Mouse    89 QDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIP-DKNGRLPLHAATAEPDVRLLIVLLQQSSLS 152

  Fly  1616 EA--QDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQG------------ 1666
            |.  ||.||.|.|.||.........:.|::.|.:....|.:.:|||..|...|
Mouse   153 EINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHR 217

  Fly  1667 -AASLVIYILEQGGNLEHI-------DVHGMRPLDRAIACRNIQAVQVFLRKGAKLGPTTWSMAM 1723
             ..|::.|..|.|....||       |:  :..|.:...| |:||:.|..|.     |..|:.|.
Mouse   218 QGPSIINYDDESGKTCVHIAAASGFGDI--INDLAKVPEC-NLQALDVDDRT-----PLHWAAAS 274

  Fly  1724 GKPEILVILL----NKLLEDGN------------------VLYRKNRFQEAAHRYQYALRKI-SG 1765
            ||.|.:..||    :..|.|.|                  :|.|:.|.:.|        |.: |.
Mouse   275 GKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLLSREGRAEPA--------RPLPSQ 331

  Fly  1766 LEQLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMELGA 1830
            ..|..::...|:      :||...||.|..|             ||.|..:...||.|.. |...
Mouse   332 NSQPQKKEGRFS------MLNQIFCKNKKEE-------------QKAHQKDQSRARPKEE-ETSE 376

  Fly  1831 LN------EALVDANEAMQQAAQSGVLCEVVEVLKR----------------------IQTELLT 1867
            :|      :::||.|    ...|.|...::|...||                      |:|:.|.
Mouse   377 VNDIIATFDSVVDTN----CQGQPGDQVDMVVFKKRTSENSKYLLPEKKSLARKGLPPIRTQSLP 437

  Fly  1868 RISISSEDQT---GRMSNIG 1884
            .|::.....|   |.:|:.|
Mouse   438 PITLGGHFLTASQGAVSHAG 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rols	NP_729778.1	zf-RING_5	327..364	CDD:291308
		Ank_5	1363..1418	CDD:290568
		ANK	1378..1503	CDD:238125
		ANK repeat	1382..1408	CDD:293786
		ANK repeat	1410..1441	CDD:293786
		Ank_2	1415..1552	CDD:289560	17/65 (26%)
		ANK	1486..1609	CDD:238125	32/122 (26%)
		ANK repeat	1486..1518	CDD:293786	3/8 (38%)
		ANK repeat	1521..1552	CDD:293786	13/53 (25%)
		Ank_2	1526..1619	CDD:289560	30/116 (26%)
		ANK	1549..1675	CDD:238125	36/140 (26%)
		ANK repeat	1554..1586	CDD:293786	10/31 (32%)
		ANK repeat	1591..1619	CDD:293786	8/29 (28%)
		Ank_2	1593..1685	CDD:289560	29/113 (26%)
		ANK repeat	1621..1652	CDD:293786	8/30 (27%)
		ANK repeat	1654..1685	CDD:293786	11/50 (22%)
		Ank_2	1659..1735	CDD:289560	25/99 (25%)
		ANK repeat	1687..1712	CDD:293786	7/24 (29%)
		TPR_11	1736..1812	CDD:290150	18/94 (19%)
		TPR repeat	1736..1768	CDD:276809	9/50 (18%)
		TPR repeat	1773..1810	CDD:276809	7/36 (19%)
		TPR_11	1783..1843	CDD:290150	17/65 (26%)
		TPR repeat	1815..1843	CDD:276809	8/33 (24%)
Ankrd55	NP_084174.2	PHA03095	20..>314	CDD:222980	76/298 (26%)
		ANK 1	25..54		7/28 (25%)
		ANK repeat	59..90	CDD:293786	9/30 (30%)
		ANK 2	59..88		9/28 (32%)
		ANK 3	92..124		10/32 (31%)
		ANK repeat	92..123	CDD:293786	10/31 (32%)
		ANK repeat	125..158	CDD:293786	8/32 (25%)
		ANK 4	125..156		8/30 (27%)
		ANK repeat	160..191	CDD:293786	8/30 (27%)
		ANK 5	160..189		8/28 (29%)
		ANK repeat	193..261	CDD:293786	17/70 (24%)
		ANK 6	193..222		5/28 (18%)
		ANK 7	229..259		7/32 (22%)
		ANK repeat	229..254	CDD:293786	5/26 (19%)
		ANK repeat	263..294	CDD:293786	10/35 (29%)
		ANK 8	263..292		9/33 (27%)
		ANK 9	296..325		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..377		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..491		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..626
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073736at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010