DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rols and Tanc2

DIOPT Version :9

Sequence 1:NP_729778.1 Gene:rols / 39368 FlyBaseID:FBgn0041096 Length:1900 Species:Drosophila melanogaster
Sequence 2:XP_006534535.1 Gene:Tanc2 / 77097 MGIID:2444121 Length:2079 Species:Mus musculus


Alignment Length:1295 Identity:525/1295 - (40%)
Similarity:741/1295 - (57%) Gaps:134/1295 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   683 DHHSSFLNEKLQKDQLHARLG--LLLNDPGSNGNSSSSGSGCEPISAH------------STTST 733
            |.:|..:.::.|...:..|:.  ..|....::..:||..|...|:|.:            |.|||
Mouse   183 DQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPVSTNAAAKDCSYGAVTSPTST 247

  Fly   734 TSSSGVGAASTTTS------------------GSSQNVSPEQTLAS------------------G 762
            ..|...|..:|.|:                  ||..|:.|.|:..|                  .
Mouse   248 LESRDSGIIATLTNYSENMERTKYVGEGSKELGSGGNLKPWQSQKSSMDSCLYRVDENMAASTYS 312

  Fly   763 AGMLSGSQLSVATSHGVKEDALSLCGK--FKAGCSMLHVYE-ALPSKSRKGNVRRSTRGQQGSSS 824
            ...:....|....|..|:...|.|..:  ..|..|..|:.: |...:.|...:|.|.|..:.|.|
Mouse   313 LNKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSLS 377

  Fly   825 SASAASAVGSRVTASSLAAVQLALKPLFFEVPLQEPDPPYVGRQWLVQQLSNILLGTETRV---V 886
            .|.....:  ||..:......::||||.||||....:..:|||.|:..::...|..:...|   |
Mouse   378 GARTQQDL--RVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGV 440

  Fly   887 LINGQPGTGKTAFCLQLVEYSCFGRRQMQ---DDP------------------DGIYSQLQLGAH 930
            :|.|..|.||||...:||..||.|.|..|   |.|                  ...:|.:..|: 
Mouse   441 VIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQAPSAHSSITSGS- 504

  Fly   931 C-----------ERMRGLASHMVGYHFCQADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSE 984
            |           |.||.|||.:|.||:||||...||.||:|||::||.||::|||||||:.||.|
Mouse   505 CPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLRE 569

  Fly   985 PHLQDILSVRECIADAERVMKLAILEPLAHLHRAGKIPAKVAVIVVDALCEAEYHRPDHGHTIAS 1049
            ||||.:||:|.|:.|.....:..:||||.:||:..|||.:..:|::|.|.|||:|:||:|.||.|
Mouse   570 PHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVS 634

  Fly  1050 FLAQLTPHFPAWLKLVATVRTQMLELVKAPSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIR 1114
            ||:::..:||:||||:.||||.:.|:.|...:.::.||....::|:.||:..||..|:..|.||:
Mouse   635 FLSKMIGNFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQ 699

  Fly  1115 MNIG-GGGGQNSQSGSQPQTKFVSHLQSLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSLAQ 1178
            .||. .|...|:..|     |..|||::||:||.||.||..|||.:|.||:|||||||:||||::
Mouse   700 NNISLNGKMDNTTFG-----KLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSE 759

  Fly  1179 IFLLHFNLRFPTARSFEQAAPILNICLAALYPLTLDEIYYSMEALS-HGREALSWPDFMQRFKLL 1242
            ::||..|::|||..||::..|:||:.:|:|:|||.:.|:.::.|.| .|  .|.|.||.||.:.|
Mouse   760 VYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEG--TLEWEDFQQRMENL 822

  Fly  1243 DGFLIKRLDNTYMFFHSSLREWLMRRDEGESNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLELG 1307
            ..|||||.|.|.||.|.|.||||:.|:|||..|||||.|.||..:||..||.:..|:.|.|:|||
Mouse   823 SMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELG 887

  Fly  1308 HHMLKAHLYGGTSLTL-LSPRDLQSYWLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASPNH 1371
            ||:||||::.|.|..: :|...||..|::.:.:.:|.:|.:|||:|:||:|||||::|.||:.|:
Mouse   888 HHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINY 952

  Fly  1372 RTDYMGGAPILCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSS 1436
            ||:.:..|||||:.:|.|...||:|||||||:|..::..|.|||..||..|...:|..|....:.
Mouse   953 RTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGFLSIVVLLCKKRAK 1017

  Fly  1437 LGQLDITQRCALVHAARMGHLSVVKYLLACDWSPRPHSQDV-TRSVALQQALIGAAAQAHCKILE 1500
            :..||...:|||||||..|||.|||:|:.|||:.....|.| .:|.|:|||||.||:..:.:|:.
Mouse  1018 VDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVS 1082

  Fly  1501 DLLDLNETEFD----LDVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWL 1561
            .||||.|.:.:    ..:|..:...||.||||||..|.:||..:||.:||.:...||:|...|:.
Mouse  1083 YLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGAVPLFS 1147

  Fly  1562 AVKEGHWSVVEHLLQRGALLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTAL 1626
            .|::|||.:|:.||..||.::....|.| ||||:||.||||..||.|||:||.....|.||.|||
Mouse  1148 TVRQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTAL 1211

  Fly  1627 SWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRP 1691
            |||||:|||:..::|:::|....|.|.||||.|||||:.|.|.:|.::::.|..:||:|..||||
Mouse  1212 SWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRP 1276

  Fly  1692 LDRAIACRNIQAVQVFLRKGAKL----------GPTTWSMAMGKPEILVILLNKLLEDGNVLYRK 1746
            ||||:.|||...|...|:||||:          ||.||:||..||:|::|||:||:|:|::.|:|
Mouse  1277 LDRAVGCRNTSVVVTLLKKGAKIGCQTLPSRPRGPATWAMATSKPDIMIILLSKLMEEGDMFYKK 1341

  Fly  1747 NRFQEAAHRYQYALRKI--SGLEQLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAIA 1809
            .:.:|||.||||||:|.  .|..:.|:   .|.:|:.:||||||||:||:|:...:.:.||:|:.
Mouse  1342 GKVKEAAQRYQYALKKFPREGFGEDLK---TFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALE 1403

  Fly  1810 QKPHSYEGYYARAKA-RMELGALNEALVDANEAMQQAAQSGVLC----EVVEVLKRIQTE 1864
            .||.|||.|||||:| |........||.|..||::       ||    |:..:|.|::.|
Mouse  1404 LKPKSYEAYYARARAKRSSSRQFAAALEDLKEAIK-------LCPNNREIQRLLMRVEEE 1456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rolsNP_729778.1 zf-RING_5 327..364 CDD:291308
Ank_5 1363..1418 CDD:290568 27/54 (50%)
ANK 1378..1503 CDD:238125 57/125 (46%)
ANK repeat 1382..1408 CDD:293786 14/25 (56%)
ANK repeat 1410..1441 CDD:293786 9/30 (30%)
Ank_2 1415..1552 CDD:289560 58/141 (41%)
ANK 1486..1609 CDD:238125 54/126 (43%)
ANK repeat 1486..1518 CDD:293786 12/35 (34%)
ANK repeat 1521..1552 CDD:293786 15/30 (50%)
Ank_2 1526..1619 CDD:289560 44/92 (48%)
ANK 1549..1675 CDD:238125 62/125 (50%)
ANK repeat 1554..1586 CDD:293786 11/31 (35%)
ANK repeat 1591..1619 CDD:293786 17/27 (63%)
Ank_2 1593..1685 CDD:289560 48/91 (53%)
ANK repeat 1621..1652 CDD:293786 16/30 (53%)
ANK repeat 1654..1685 CDD:293786 15/30 (50%)
Ank_2 1659..1735 CDD:289560 41/85 (48%)
ANK repeat 1687..1712 CDD:293786 14/24 (58%)
TPR_11 1736..1812 CDD:290150 33/77 (43%)
TPR repeat 1736..1768 CDD:276809 16/33 (48%)
TPR repeat 1773..1810 CDD:276809 16/36 (44%)
TPR_11 1783..1843 CDD:290150 31/60 (52%)
TPR repeat 1815..1843 CDD:276809 14/28 (50%)
Tanc2XP_006534535.1 AAA_16 415..>500 CDD:379062 24/84 (29%)
PHA03095 930..>1224 CDD:222980 140/294 (48%)
ANK repeat 963..989 CDD:293786 14/25 (56%)
ANK repeat 991..1022 CDD:293786 9/30 (30%)
ANK repeat 1108..1138 CDD:293786 15/29 (52%)
ANK repeat 1140..1171 CDD:293786 11/30 (37%)
ANKYR <1170..1296 CDD:223738 66/126 (52%)
ANK repeat 1174..1204 CDD:293786 18/30 (60%)
ANK repeat 1206..1237 CDD:293786 16/30 (53%)
ANK repeat 1239..1270 CDD:293786 15/30 (50%)
ANK repeat 1272..1302 CDD:293786 17/29 (59%)
TPR <1324..1442 CDD:223533 56/127 (44%)
TPR repeat 1331..1356 CDD:276809 13/24 (54%)
TPR repeat 1361..1404 CDD:276809 18/45 (40%)
TPR repeat 1409..1438 CDD:276809 14/28 (50%)
PHA03247 <1515..1745 CDD:223021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BH8T
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 869 1.000 Inparanoid score I413
Isobase 1 0.950 - 0 Normalized mean entropy S5183
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1073736at2759
OrthoFinder 1 1.000 - - FOG0003165
OrthoInspector 1 1.000 - - otm43890
orthoMCL 1 0.900 - - OOG6_105209
Panther 1 1.100 - - O PTHR24166
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5649
SonicParanoid 1 1.000 - - X1834
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.810

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