DRSC/TRiP Functional Genomics Resources

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Protein Alignment rols and Tanc2

DIOPT Version :10

Sequence 1:NP_729778.1 Gene:rols / 39368 FlyBaseID:FBgn0041096 Length:1900 Species:Drosophila melanogaster
Sequence 2:XP_006534535.1 Gene:Tanc2 / 77097 MGIID:2444121 Length:2079 Species:Mus musculus


Alignment Length:1297 Identity:525/1297 - (40%)
Similarity:741/1297 - (57%) Gaps:138/1297 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   683 DHHSSFLNEKLQKDQLHARLG--LLLNDPGSNGNSSSSGSGCEPISAH------------STTST 733
            |.:|..:.::.|...:..|:.  ..|....::..:||..|...|:|.:            |.|||
Mouse   183 DQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPVSTNAAAKDCSYGAVTSPTST 247

  Fly   734 TSSSGVGAASTTTS------------------GSSQNVSPEQTLAS------------------G 762
            ..|...|..:|.|:                  ||..|:.|.|:..|                  .
Mouse   248 LESRDSGIIATLTNYSENMERTKYVGEGSKELGSGGNLKPWQSQKSSMDSCLYRVDENMAASTYS 312

  Fly   763 AGMLSGSQLSVATSHGVKEDALSLCGK--FKAGCSMLHVYE-ALPSKSRKGNVRRSTRGQQGSSS 824
            ...:....|....|..|:...|.|..:  ..|..|..|:.: |...:.|...:|.|.|..:.|.|
Mouse   313 LNKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSLS 377

  Fly   825 SASAASAVGSRVTASSLAAVQLALKPLFFEVPLQEPDPPYVGRQWLVQQLSNILLGTETRV---V 886
            .|.....:  ||..:......::||||.||||....:..:|||.|:..::...|..:...|   |
Mouse   378 GARTQQDL--RVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGV 440

  Fly   887 LINGQPGTGKTAFCLQLVEYSCFGRRQMQ---DDP------------------DGIYSQLQLGAH 930
            :|.|..|.||||...:||..||.|.|..|   |.|                  ...:|.:..|: 
Mouse   441 VIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQAPSAHSSITSGS- 504

  Fly   931 C-----------ERMRGLASHMVGYHFCQADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSE 984
            |           |.||.|||.:|.||:||||...||.||:|||::||.||::|||||||:.||.|
Mouse   505 CPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLRE 569

  Fly   985 PHLQDILSVRECIADAERVMKLAILEPLAHLHRAGKIPAKVAVIVVDALCEAEYHRPDHGHTIAS 1049
            ||||.:||:|.|:.|.....:..:||||.:||:..|||.:..:|::|.|.|||:|:||:|.||.|
Mouse   570 PHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVS 634

  Fly  1050 FLAQLTPHFPAWLKLVATVRTQMLELVKAPSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIR 1114
            ||:::..:||:||||:.||||.:.|:.|...:.::.||....::|:.||:..||..|:..|.||:
Mouse   635 FLSKMIGNFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQ 699

  Fly  1115 MNIGGGGGQNSQSGSQPQT---KFVSHLQSLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSL 1176
            .||       |.:|....|   |..|||::||:||.||.||..|||.:|.||:|||||||:||||
Mouse   700 NNI-------SLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSL 757

  Fly  1177 AQIFLLHFNLRFPTARSFEQAAPILNICLAALYPLTLDEIYYSMEALS-HGREALSWPDFMQRFK 1240
            ::::||..|::|||..||::..|:||:.:|:|:|||.:.|:.::.|.| .|  .|.|.||.||.:
Mouse   758 SEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEG--TLEWEDFQQRME 820

  Fly  1241 LLDGFLIKRLDNTYMFFHSSLREWLMRRDEGESNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLE 1305
            .|..|||||.|.|.||.|.|.||||:.|:|||..|||||.|.||..:||..||.:..|:.|.|:|
Mouse   821 NLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIE 885

  Fly  1306 LGHHMLKAHLYGGTSLTL-LSPRDLQSYWLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASP 1369
            ||||:||||::.|.|..: :|...||..|::.:.:.:|.:|.:|||:|:||:|||||::|.||:.
Mouse   886 LGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANI 950

  Fly  1370 NHRTDYMGGAPILCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAG 1434
            |:||:.:..|||||:.:|.|...||:|||||||:|..::..|.|||..||..|...:|..|....
Mouse   951 NYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGFLSIVVLLCKKR 1015

  Fly  1435 SSLGQLDITQRCALVHAARMGHLSVVKYLLACDWSPRPHSQDV-TRSVALQQALIGAAAQAHCKI 1498
            :.:..||...:|||||||..|||.|||:|:.|||:.....|.| .:|.|:|||||.||:..:.:|
Mouse  1016 AKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEI 1080

  Fly  1499 LEDLLDLNETEFD----LDVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSAL 1559
            :..||||.|.:.:    ..:|..:...||.||||||..|.:||..:||.:||.:...||:|...|
Mouse  1081 VSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGAVPL 1145

  Fly  1560 WLAVKEGHWSVVEHLLQRGALLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFT 1624
            :..|::|||.:|:.||..||.::....|.| ||||:||.||||..||.|||:||.....|.||.|
Mouse  1146 FSTVRQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLT 1209

  Fly  1625 ALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGM 1689
            |||||||:|||:..::|:::|....|.|.||||.|||||:.|.|.:|.::::.|..:||:|..||
Mouse  1210 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGM 1274

  Fly  1690 RPLDRAIACRNIQAVQVFLRKGAKL----------GPTTWSMAMGKPEILVILLNKLLEDGNVLY 1744
            ||||||:.|||...|...|:||||:          ||.||:||..||:|::|||:||:|:|::.|
Mouse  1275 RPLDRAVGCRNTSVVVTLLKKGAKIGCQTLPSRPRGPATWAMATSKPDIMIILLSKLMEEGDMFY 1339

  Fly  1745 RKNRFQEAAHRYQYALRKI--SGLEQLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQA 1807
            :|.:.:|||.||||||:|.  .|..:.|:   .|.:|:.:||||||||:||:|:...:.:.||:|
Mouse  1340 KKGKVKEAAQRYQYALKKFPREGFGEDLK---TFRELKVSLLLNLSRCRRKMNDFGMAEEFATKA 1401

  Fly  1808 IAQKPHSYEGYYARAKA-RMELGALNEALVDANEAMQQAAQSGVLC----EVVEVLKRIQTE 1864
            :..||.|||.|||||:| |........||.|..||::       ||    |:..:|.|::.|
Mouse  1402 LELKPKSYEAYYARARAKRSSSRQFAAALEDLKEAIK-------LCPNNREIQRLLMRVEEE 1456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rolsNP_729778.1 zf-RING_5 327..364 CDD:434085
Ank_2 1382..1467 CDD:463710 39/84 (46%)
ANK repeat 1382..1408 CDD:293786 14/25 (56%)
ANK repeat 1410..1441 CDD:293786 9/30 (30%)
ANKYR 1481..1714 CDD:440430 112/236 (47%)
ANK repeat 1486..1518 CDD:293786 12/35 (34%)
ANK repeat 1521..1552 CDD:293786 15/30 (50%)
ANK repeat 1554..1586 CDD:293786 11/31 (35%)
ANK repeat 1591..1619 CDD:293786 17/27 (63%)
Spy 1608..>1847 CDD:443119 119/251 (47%)
ANK repeat 1621..1652 CDD:293786 16/30 (53%)
ANK repeat 1654..1685 CDD:293786 15/30 (50%)
ANK repeat 1687..1712 CDD:293786 14/24 (58%)
TPR repeat 1736..1768 CDD:276809 16/33 (48%)
TPR repeat 1773..1810 CDD:276809 16/36 (44%)
TPR repeat 1815..1843 CDD:276809 14/28 (50%)
Tanc2XP_006534535.1 PHA03095 930..>1224 CDD:222980 140/294 (48%)
ANK repeat 963..989 CDD:293786 14/25 (56%)
ANK repeat 991..1022 CDD:293786 9/30 (30%)
ANKYR 1100..1299 CDD:440430 98/199 (49%)
ANK repeat 1108..1138 CDD:293786 15/29 (52%)
ANK repeat 1140..1171 CDD:293786 11/30 (37%)
ANK repeat 1174..1204 CDD:293786 18/30 (60%)
ANK repeat 1206..1237 CDD:293786 16/30 (53%)
ANK repeat 1239..1270 CDD:293786 15/30 (50%)
ANK repeat 1272..1302 CDD:293786 17/29 (59%)
TPR repeat 1331..1356 CDD:276809 13/24 (54%)
TPR 1335..>1450 CDD:440225 51/124 (41%)
TPR repeat 1361..1404 CDD:276809 18/45 (40%)
TPR repeat 1409..1438 CDD:276809 14/28 (50%)
PAT1 1525..>1717 CDD:401645
Blue background indicates that the domain is not in the aligned region.

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