DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rols and Tanc1

DIOPT Version :10

Sequence 1:NP_729778.1 Gene:rols / 39368 FlyBaseID:FBgn0041096 Length:1900 Species:Drosophila melanogaster
Sequence 2:XP_006500097.1 Gene:Tanc1 / 66860 MGIID:1914110 Length:1874 Species:Mus musculus


Alignment Length:1421 Identity:534/1421 - (37%)
Similarity:768/1421 - (54%) Gaps:210/1421 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   567 PIDTASILSGDHTHQHHHRDNQPEGKESNALNTSTCSDSAVTRRRRKNVSNHNLKTSARHGASSE 631
            |.|...|..|:.:     :.::|...|:.|.|..:||.:|                        :
Mouse    98 PGDPVMIPFGEGS-----KPSEPSATEAKADNEPSCSPAA------------------------Q 133

  Fly   632 NRLNRLS-LAGTSV-YAGHLS------SLVFGKIKSLW-----------SVNSSNSSEAGLNQLA 677
            ..|.||. |.|..: .|.|::      ::|..:.::.:           :::...|..:.|....
Mouse   134 ELLTRLGFLLGEGIPSATHITIEDKNEAMVMPEEEAAFPTCSACTLPCTALSQGISPCSTLTSST 198

  Fly   678 GSDAIDHHSSFLNEKLQKDQLHARLGLLLNDPGSNGNSSSSGSGCEPISAHSTTSTTSSSGVGAA 742
            .|.:.|...|.||..:.|                   :::|.|.||.||:.|:|..:..||:.|.
Mouse   199 ASPSTDSPCSTLNSCVSK-------------------TAASKSPCETISSPSSTLESKDSGIIAT 244

  Fly   743 STT--------------------------------------------TSGSSQNVSPEQTLASGA 763
            .|:                                            |:||:::|.|:...::|.
Mouse   245 ITSSSENDDRSGSSLEWNRDGSLRLGVQKGVLHDRRADNCSPVAEEETTGSAESVLPKAEPSAGD 309

  Fly   764 GML-----SGSQL-----SVATSHGVK-EDALSLCGKFKAGCSMLHVYEALPSKSRKGNVRRSTR 817
            |.:     |||.:     |||.:...| ||...|.|:                  |...:|.|.|
Mouse   310 GPVPYPQSSGSLIMPRPNSVAATSSTKLEDLSYLDGQ------------------RNAPLRTSIR 356

  Fly   818 GQQGSSSSASAASAVGSRVTASSLAAVQLALKPLFFEVPLQEPDPPYVGRQWLVQQLSNILLGT- 881
             ....:::...|..|.:|.  :.....::.||||.||||....|..:|||.||..|:...|..| 
Mouse   357 -LPWHNTAGGRAPEVKARF--APYKPQEILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTE 418

  Fly   882 --ETRVVLINGQPGTGKTAFCLQLVEYSCFGRRQMQD------------------------DPDG 920
              |.|..::.|..|.||||...:||..||.|.|..|.                        .|..
Mouse   419 LAENRGAVVVGSVGFGKTAIISKLVALSCHGSRMRQIASSSPSLSPKSSDPTQDLPGTPLLSPSS 483

  Fly   921 IYSQLQL--------GAHCERMRG-----LASHMVGYHFCQADANLTCQVPDFVHSLAAQLCQAP 972
            ..|.|.:        .|..:|.|.     |||.:|.||:||||...||.||:||||:||.||::.
Mouse   484 STSALSVTRTPAGPGTADSQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSH 548

  Fly   973 QLTAYRDYLLSEPHLQDILSVRECIADAERVMKLAILEPLAHLHRAGKIPAKVAVIVVDALCEAE 1037
            ||.||||.|:.||.||.:||:|.|:.|.....|..:||||..|....|||.:..:|::|.|.|||
Mouse   549 QLAAYRDLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTSLRNEQKIPEEEYIILIDGLNEAE 613

  Fly  1038 YHRPDHGHTIASFLAQLTPHFPAWLKLVATVRTQMLELVKAPSYTQLTLDSWASSQALQQDMLDY 1102
            :|:||:|.|::||:.::.|.||.||||:.|||....|::.|..:.:|:||.:..::.:..|:..|
Mouse   614 FHKPDYGDTLSSFITKIIPKFPTWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDLHAY 678

  Fly  1103 IGARLADSPEIRMNIGGGGGQNSQSGSQPQTKFVSHLQSLSRGSMLYAKLILDLIARGQLVIKSS 1167
            :..|:..|.:|..||    ..|.::.:...:|..|||...|.||.||.||.|||..||.|||||:
Mouse   679 VQHRVHSSQDILSNI----SLNGKADAALISKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSA 739

  Fly  1168 SYKVLPVSLAQIFLLHFNLRFPTARSFEQAAPILNICLAALYPLTLDEIYYSMEALSHGREALSW 1232
            ||||:||||::::||..|::|.|..:|::|.||||:.||:|:|:|.::|:.::.| .|.:....|
Mouse   740 SYKVVPVSLSELYLLQCNMKFMTQSAFDRALPILNVALASLHPMTDEQIFQAINA-GHIQGEQGW 803

  Fly  1233 PDFMQRFKLLDGFLIKRLDNTYMFFHSSLREWLMRRDEGESNKFLCDARLGHAGIAFRLSRLQAP 1297
            .||.||.:.|..|||||.|.|.||.|.|.||||:.|.:|||..|||:.|.|||.:||..||.::.
Mouse   804 EDFQQRMEALSCFLIKRRDKTRMFCHPSFREWLVWRADGESTAFLCEPRNGHALLAFMFSRQESK 868

  Fly  1298 LSPQLTLELGHHMLKAHLYGGTS-LTLLSPRDLQSYWLAGAADNISSSLGALRNVYSPNLKVSRL 1361
            |:.|.|:|||||:||||::.|.| .|.:|...||:.|:..:.:.:|::|.:|||:|:||:|||||
Mouse   869 LNRQQTMELGHHILKAHIFKGLSKKTGVSSSHLQALWIGYSTEGLSAALASLRNLYTPNVKVSRL 933

  Fly  1362 VLLAGASPNHRTDYMGGAPILCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDV 1426
            ::|.||:.|:||:.:..|||||:.:|.|...:|:|||||||.:...:..|...|..||..||..:
Mouse   934 LILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKL 998

  Fly  1427 VRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVKYLLACDWS---PRPHSQDVTRSVALQQALI 1488
            |..|:..|:.:..||...:|||||:|..||..:::|||.|:||   |:|.:  :.:|.||||||.
Mouse   999 VCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGT--LRKSQALQQALT 1061

  Fly  1489 GAAAQAHCKILEDLLDLNETEFDLDVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNR 1553
            .||:..|..:::.||.:.| |.:::|||.:...||.||||||..|.:::..:||.|||.:...||
Mouse  1062 AAASMGHSSVVQSLLGMAE-EHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANR 1125

  Fly  1554 QGYSALWLAVKEGHWSVVEHLLQRGALLDEPLGQTR-KTPLMIAAEEGHLELVDLLLARGAQREA 1617
            :|...|:.|.::|||.||..||.||.  |..|...: :||||:|:.||||..|:.||::||...:
Mouse  1126 RGVPPLFCAARQGHWQVVRLLLDRGC--DVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSS 1188

  Fly  1618 QDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLE 1682
            .|.||.:|||||||:||.|..:.|:|.|......|.||||.|||||:.|.|..|:|::|:|..:|
Mouse  1189 LDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1253

  Fly  1683 HIDVHGMRPLDRAIACRNIQAVQVFLRKGAKLGPTTWSMAMGKPEILVILLNKLLEDGNVLYRKN 1747
            |:|..|||||||||.|||...|...||||||||...|:||..||:||:|||.||:|:|||:|:|.
Mouse  1254 HVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAAWAMATSKPDILIILLQKLVEEGNVMYKKG 1318

  Fly  1748 RFQEAAHRYQYALRKISGLEQLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAIAQKP 1812
            :.:|||.||||||||.. .|.|.|....|.:||.:|.||||||:||.|:...:.:.|::|:..||
Mouse  1319 KMKEAAQRYQYALRKFP-REGLGEDMRPFNELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKP 1382

  Fly  1813 HSYEGYYARAKARMELGALNEALVDANEAMQQAAQSGVLC----EVVEVLKRIQTE 1864
            .|||.:||||:|:........||.|..||::       ||    |:..:|.|::.|
Mouse  1383 KSYEAFYARARAKRNSRQFLAALADLQEAVK-------LCPNNQEIKRLLARVEEE 1431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rolsNP_729778.1 zf-RING_5 327..364 CDD:434085
Ank_2 1382..1467 CDD:463710 34/84 (40%)
ANK repeat 1382..1408 CDD:293786 12/25 (48%)
ANK repeat 1410..1441 CDD:293786 9/30 (30%)
ANKYR 1481..1714 CDD:440430 113/233 (48%)
ANK repeat 1486..1518 CDD:293786 12/31 (39%)
ANK repeat 1521..1552 CDD:293786 14/30 (47%)
ANK repeat 1554..1586 CDD:293786 13/31 (42%)
ANK repeat 1591..1619 CDD:293786 14/27 (52%)
Spy 1608..>1847 CDD:443119 122/238 (51%)
ANK repeat 1621..1652 CDD:293786 15/30 (50%)
ANK repeat 1654..1685 CDD:293786 17/30 (57%)
ANK repeat 1687..1712 CDD:293786 16/24 (67%)
TPR repeat 1736..1768 CDD:276809 18/31 (58%)
TPR repeat 1773..1810 CDD:276809 15/36 (42%)
TPR repeat 1815..1843 CDD:276809 12/27 (44%)
Tanc1XP_006500097.1 DUF5585 109..>383 CDD:465521 60/342 (18%)
NACHT <536..1157 CDD:444362 280/630 (44%)
PHA03095 921..>1233 CDD:222980 142/316 (45%)
ANK repeat 954..980 CDD:293786 12/25 (48%)
ANK repeat 986..1013 CDD:293786 8/26 (31%)
ANK repeat 1015..1090 CDD:293786 33/77 (43%)
ANKYR 1094..1310 CDD:440430 112/217 (52%)
ANK repeat 1094..1124 CDD:293786 14/29 (48%)
ANK repeat 1130..1157 CDD:293786 13/28 (46%)
ANK repeat 1160..1190 CDD:293786 14/29 (48%)
ANK repeat 1192..1223 CDD:293786 15/30 (50%)
ANK repeat 1225..1256 CDD:293786 17/30 (57%)
ANK repeat 1258..1283 CDD:293786 16/24 (67%)
TPR repeat 1307..1332 CDD:276809 15/24 (63%)
TPR 1311..>1428 CDD:440225 53/124 (43%)
TPR repeat 1350..1380 CDD:276809 13/29 (45%)
TPR repeat 1385..1413 CDD:276809 12/27 (44%)
Blue background indicates that the domain is not in the aligned region.

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