DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rols and ANKRD50

DIOPT Version :9

Sequence 1:	NP_729778.1	Gene:	rols / 39368	FlyBaseID:	FBgn0041096	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_065070.1	Gene:	ANKRD50 / 57182	HGNCID:	29223	Length:	1429	Species:	Homo sapiens

Alignment Length:	1065	Identity:	301/1065 - (28%)
Similarity:	476/1065 - (44%)	Gaps:	165/1065 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   886 VLINGQPGTGKTAFCLQLVEYSCFGRRQMQDDPDGIYSQLQLGAHCERMRGLASHMVGYHFCQAD 950
            ||:.|.||:||||.|.:|:         ....|    :.||        |||....:.:|||:|.
Human    73 VLLVGGPGSGKTALCTELL---------WPSSP----ASLQ--------RGLHRQALAFHFCKAQ 116

  Fly   951 ANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSEPHLQDILSVRECIADAERVMKLAILEPLAHL 1015
            .:.|..|..|:..|.||:|::..|..|.| .|.:|.:|.:|...||..:.....|..:|.||..:
Human   117 DSDTLCVGGFIRGLVAQICRSGLLQGYED-KLRDPAVQSLLQPGECERNPAEAFKRCVLLPLLGM 180

  Fly  1016 HRAGKIPAKVAVIVVDA------LCEAEYHRPDHGHTIASFLAQLTPHFPAWLKLVATVRTQMLE 1074
                |.|.:...::||:      :.|.|........|:|:.||.....||.||.|:.:.|.|...
Human   181 ----KPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTVAALLAGHHEFFPPWLLLLCSARKQSKA 241

  Fly  1075 LVKA-PSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIRMNIGGGGGQNSQSGSQPQTKFVSH 1138
            :.|. ..:.:::||....:. :.:|:..||..||.....:|.::           ::...:.::.
Human   242 VTKMFTGFRKISLDDLRKAY-IVKDVQQYILHRLDQEEALRQHL-----------TKETAEMLNQ 294

  Fly  1139 LQSLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSLAQIFLLHFNLRFPTARSFEQAAPILNI 1203
            |...|.|..||.:.:||.:....::::  ..:.:|.:|..::|......| ..:.|.:..||||:
Human   295 LHIKSSGCFLYLERVLDGVVENFIMLR--EIRDIPGTLNGLYLWLCQRLF-VRKQFAKVQPILNV 356

  Fly  1204 CLAALYPLTLDEIYYSMEALSHGREALSWPDFMQRFKLLDGFLIKRLDNTYMFFHSSLREWLMRR 1268
            .|||..|||:.|:|:   |:.....:|:..||.::..:|...|:..|.||.:.||.|..|||:
Human   357 ILAACRPLTITELYH---AVWTKNMSLTLEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLL-- 416

  Fly  1269 DEGE-SNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLELGHHMLKAHL------------YGGT- 1319
            |... :.|:||:|..||..:|...:.....|:|....|...|::.::|            :.||
Human   417 DVKHCTQKYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQLETAELALWMIWNGTP 481

  Fly  1320 ---SLTLLSPRD---LQSYWLAGA----ADNISSSLGALRNVYSPNLKVSRLVLLAGASPNHRTD 1374
               ||:.|.|::   ||....|||    .|:.:|.:  :|........: |.:|..|||.|....
Human   482 VRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCI--VRQALEREDSI-RTLLDNGASVNQCDS 543

  Fly  1375 YMGGAPILCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQ 1439
              .|..:|..||:.|.|.:|:||:..|||:.:.::.|.|||.|||.:||..||..|:..|:::..
Human   544 --NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINH 606

  Fly  1440 LDITQRCALVHAARMGHLSVVKYLL------------------ACDWSPR--------PHSQDVT 1478
            .|.....||..||..||..||..||                  |..|...        .|..:|.
Human   607 TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671

  Fly  1479 RS-VALQQALIGAAAQAHCKILEDLLDLNETEFDLDVNGMEPSSGELALTAAARHGCIDVVGILL 1542
            :: ...:.|||.||...|.:|:|.|||........||:|....| ..||...|..|...||.:|:
Human   672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALS-VAALCVPASKGHASVVSLLI 735

  Fly  1543 SRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEPLGQTRKTPLMIAAEEGHLELVDL 1607
            .|||::|..::.|.:.|.:|..|||..||:.||:.||.:|. .....:|||:.||..||..:|:.
Human   736 DRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDH-TDNNGRTPLLAAASMGHASVVNT 799

  Fly  1608 LLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVI 1672
            ||..||..::.|.||.|.||.|..:|::...:||::.|.:.:|.|..|.|.|.:||::|...:..
Human   800 LLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICE 864

  Fly  1673 YILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGAKL------GPTTWSMAM--GKPEIL 1729
            .::|||.....||..|..|...|....:...||:.|...:.:      |.....:|.  |..:|:
Human   865 ALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929

  Fly  1730 VIL------LNKLLEDGN----VLYRKNRFQEAAHRYQYALRKISGLEQLLERNAIFAQLRTNLL 1784
            .:|      :|....||.    :|..:|:...|    :|.|...:.:|      |..|:.||.|.
Human   930 ELLFSHGADVNCKDADGRPTLYILALENQLTMA----EYFLENGANVE------ASDAEGRTALH 984

  Fly  1785 LN-----------LSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMELGALNEALVD- 1837
            ::           |......:|..|.....|.|:.|     ::|:....:..:|.|    |:||
Human   985 VSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA-----WQGHVKVVQLLIEHG----AVVDH 1040

  Fly  1838 -ANE---AMQQAAQSGVLCEVVEVL 1858
             .|:   |:..|||.|.: :||:||
Human  1041 TCNQGATALCIAAQEGHI-DVVQVL 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rols	NP_729778.1	zf-RING_5	327..364	CDD:291308
		Ank_5	1363..1418	CDD:290568	21/54 (39%)
		ANK	1378..1503	CDD:238125	48/151 (32%)
		ANK repeat	1382..1408	CDD:293786	11/25 (44%)
		ANK repeat	1410..1441	CDD:293786	13/30 (43%)
		Ank_2	1415..1552	CDD:289560	51/163 (31%)
		ANK	1486..1609	CDD:238125	47/122 (39%)
		ANK repeat	1486..1518	CDD:293786	14/31 (45%)
		ANK repeat	1521..1552	CDD:293786	12/30 (40%)
		Ank_2	1526..1619	CDD:289560	35/92 (38%)
		ANK	1549..1675	CDD:238125	45/125 (36%)
		ANK repeat	1554..1586	CDD:293786	13/31 (42%)
		ANK repeat	1591..1619	CDD:293786	12/27 (44%)
		Ank_2	1593..1685	CDD:289560	32/91 (35%)
		ANK repeat	1621..1652	CDD:293786	11/30 (37%)
		ANK repeat	1654..1685	CDD:293786	9/30 (30%)
		Ank_2	1659..1735	CDD:289560	20/89 (22%)
		ANK repeat	1687..1712	CDD:293786	6/24 (25%)
		TPR_11	1736..1812	CDD:290150	19/90 (21%)
		TPR repeat	1736..1768	CDD:276809	7/35 (20%)
		TPR repeat	1773..1810	CDD:276809	10/47 (21%)
		TPR_11	1783..1843	CDD:290150	15/75 (20%)
		TPR repeat	1815..1843	CDD:276809	8/32 (25%)
ANKRD50	NP_065070.1	AAA_16	22..195	CDD:289934	45/147 (31%)
		Cas9_REC	<221..>352	CDD:293200	28/145 (19%)
		ANK 1	477..509		11/31 (35%)
		ANK	<495..598	CDD:238125	37/107 (35%)
		ANK 2	511..540		8/31 (26%)
		Ank_5	531..585	CDD:290568	21/55 (38%)
		ANK repeat	544..575	CDD:293786	12/30 (40%)
		ANK 3	544..573		12/28 (43%)
		ANK	573..697	CDD:238125	36/123 (29%)
		ANK repeat	577..608	CDD:293786	13/30 (43%)
		ANK 4	577..606		13/28 (46%)
		Ank_2	582..674	CDD:289560	25/91 (27%)
		ANK repeat	610..641	CDD:293786	10/30 (33%)
		ANK 5	610..639		10/28 (36%)
		ANK repeat	643..674	CDD:293786	4/30 (13%)
		ANK 6	643..672		4/28 (14%)
		Ank_2	648..745	CDD:289560	30/97 (31%)
		ANK repeat	676..707	CDD:293786	11/30 (37%)
		ANK 7	676..705		11/28 (39%)
		ANK repeat	709..745	CDD:293786	13/36 (36%)
		ANK 8	709..743		12/34 (35%)
		ANK	742..867	CDD:238125	45/125 (36%)
		ANK repeat	747..778	CDD:293786	13/31 (42%)
		ANK 9	747..776		12/28 (43%)
		Ank_2	752..844	CDD:289560	36/92 (39%)
		ANK repeat	780..811	CDD:293786	12/30 (40%)
		ANK 10	780..809		12/28 (43%)
		ANK	808..932	CDD:238125	34/123 (28%)
		ANK repeat	813..844	CDD:293786	11/30 (37%)
		ANK 11	813..842		10/28 (36%)
		ANK 12	846..875		9/28 (32%)
		ANK repeat	847..877	CDD:293786	9/29 (31%)
		Ank_2	851..943	CDD:289560	21/91 (23%)
		ANK repeat	879..910	CDD:293786	6/30 (20%)
		ANK 13	879..908		6/28 (21%)
		ANK repeat	912..943	CDD:293786	6/30 (20%)
		ANK 14	912..941		5/28 (18%)
		ANK repeat	945..976	CDD:293786	9/40 (23%)
		ANK 15	945..974		8/38 (21%)
		Ank_4	946..999	CDD:290365	12/62 (19%)
		ANK	974..1097	CDD:238125	27/101 (27%)
		ANK repeat	978..1009	CDD:293786	5/30 (17%)
		ANK 16	978..1007		4/28 (14%)
		Ank_2	983..1075	CDD:289560	23/92 (25%)
		ANK repeat	1011..1042	CDD:293786	9/39 (23%)
		ANK 17	1011..1040		8/37 (22%)
		ANK repeat	1044..1075	CDD:293786	9/22 (41%)
		ANK 18	1044..1073		9/22 (41%)
		Ank_2	1049..>1110	CDD:289560	8/17 (47%)
		ANK 19	1077..1107
		ANK repeat	1077..1102	CDD:293786
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1108..1200
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1217..1296
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073736at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920