DRSC/TRiP Functional Genomics Resources

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Protein Alignment rols and tanc2a

DIOPT Version :9

Sequence 1:NP_729778.1 Gene:rols / 39368 FlyBaseID:FBgn0041096 Length:1900 Species:Drosophila melanogaster
Sequence 2:XP_021329165.1 Gene:tanc2a / 568810 ZFINID:ZDB-GENE-060130-180 Length:1995 Species:Danio rerio


Alignment Length:1398 Identity:540/1398 - (38%)
Similarity:763/1398 - (54%) Gaps:186/1398 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   632 NRLNRL----SLAGTSVYAGHLSSLVFGKIKSLWSVNSSNSSEAGLNQLAGSDAIDHHSSFLNEK 692
            ||.||.    |:.|..|:.|..:.......:.:..:   ...|.....|..|..:.|.:  ||.:
Zfish    15 NRKNRNSGSDSVEGECVFEGDYAVPPLPVTEGMQHI---RIMEGVTRSLPSSPLLSHQA--LNMR 74

  Fly   693 LQ----------------------KDQLHARLGLLLNDPGSNG---------------------- 713
            ||                      .:.|..|||.||.|..:.|                      
Zfish    75 LQPIKRLPGDEGQNLGPPPSVDEAANTLMTRLGFLLGDKVNEGPAGAQYTMEEQDDPQCLSMTQR 139

  Fly   714 --------NSSSS---GSGCEPISA-------------HSTTSTTSS-----SGVGAASTTTSGS 749
                    :|::|   ||.|..:.|             .|.||.||:     ||:.|..|:.|.:
Zfish   140 ISPCSSLASSTASPPAGSPCSTLPAGAPGNMSTRDCAYGSITSPTSTLESRDSGIIATLTSYSEN 204

  Fly   750 SQNVSPEQTLASGAGMLSGSQLSVAT--------------------------SHGVKEDALSL-- 786
            :::.......:.|:..|..:|.|:.|                          .|.|...|.|:  
Zfish   205 AEHGGKHSEGSRGSLKLWQAQKSMGTDSFLYRVDENMAASTYSLNKIPERSLEHSVSHSAHSIPL 269

  Fly   787 ----CGKFKAGCSMLHVYE-ALPSKSRKGNVRRSTRGQQGSSSSASAASAVGSRVTASSLAAVQL 846
                .....|..|..|:.: |...:.|:..:|.|.|..:.:|.|:....| ..||..:......:
Zfish   270 YLMPRPNSVAATSSAHLEDLAYLDEQRQAPLRTSLRMPRQNSGSSRTGQA-DMRVRFAPYRPPDI 333

  Fly   847 ALKPLFFEVPLQEPDPPYVGRQWLVQQLSNILLGTETRV---VLINGQPGTGKTAFCLQLVEYSC 908
            |||||.||||...||..:.||:||.|::...|..:|:..   |:|.|..|.||||...:||..||
Zfish   334 ALKPLLFEVPSLTPDAVFTGREWLFQEVDMCLRSSESTTSQGVIIVGNVGFGKTAIISRLVALSC 398

  Fly   909 FGRRQMQ------------------DDPDGIYSQLQLGAHC-----------ERMRGLASHMVGY 944
            .|.|..|                  ..|...:..|..|:.|           |.:|.||:.:|.|
Zfish   399 HGNRMRQITSDSPHASPKHGDTLPLSQPQSAHGTLVGGSSCPGTPEMRRRQEEALRRLAAQVVAY 463

  Fly   945 HFCQADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSEPHLQDILSVRECIADAERVMKLAIL 1009
            |:||:|...||.||:|||::||.||:|||:.||||.||.:||||..||:|.|:.|.....:..:|
Zfish   464 HYCQSDNAYTCLVPEFVHNVAALLCRAPQMQAYRDLLLRQPHLQSTLSLRACVQDPFNAFRRGLL 528

  Fly  1010 EPLAHLHRAGKIPAKV-AVIVVDALCEAEYHRPDHGHTIASFLAQLTPHFPAWLKLVATVRTQML 1073
            |||..|||..||..:. .:|::|.|.|||:|:||:|.||.|||.:....||.|||||.||||.:.
Zfish   529 EPLEILHRERKIACEENLIILIDGLNEAEFHKPDYGETIVSFLCKTIERFPPWLKLVVTVRTTLQ 593

  Fly  1074 ELVKAPSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIRMNIGGGGGQNSQSGSQPQTKFVSH 1138
            ::.:...:.:::||....|.|:..|:..||..||..|.||:.|:    ..|.:..:...||..:|
Zfish   594 DVTRPLPFHRISLDRLEESDAIDSDLQGYILHRLHASQEIQNNV----ALNGKLDNTAFTKLSAH 654

  Fly  1139 LQSLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSLAQIFLLHFNLRFPTARSFEQAAPILNI 1203
            |:||||||.||.||.||||.:|.||:|||||||:||:||:::||..|:||||..|||:..|:||:
Zfish   655 LKSLSRGSYLYLKLTLDLIEKGYLVLKSSSYKVVPVNLAEVYLLQLNMRFPTQSSFERVLPLLNV 719

  Fly  1204 CLAALYPLTLDEIYYSMEALSHGREALSWPDFMQRFKLLDGFLIKRLDNTYMFFHSSLREWLMRR 1268
            .:|:|:|||.::.|.::.|......::.|.||.||.:||..||:||.|.|.||.|.|.||||:.|
Zfish   720 AVASLHPLTDEQAYGAVNAGMMRGASMEWEDFQQRSELLSPFLVKRRDGTRMFIHPSFREWLIWR 784

  Fly  1269 DEGESNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLELGHHMLKAHLYGGTSLTL-LSPRDLQSY 1332
            ::||..|||||.|.||..:||..||..:.|:.|.|||||||:||||::.|.|..: :|...||..
Zfish   785 EDGEKTKFLCDPRSGHTLLAFWFSRQDSKLNRQQTLELGHHILKAHIFKGLSKKVGVSSSVLQGL 849

  Fly  1333 WLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASPNHRTDYMGGAPILCIAAHEGILPMVSLL 1397
            |::.:.:.:|::|.:|||:|:||:|||||:::.||:.|:||:.:..|||||:.||.|.|...:||
Zfish   850 WVSYSTEGLSTALASLRNLYTPNVKVSRLLIMGGANVNYRTEVLNNAPILCVHAHLGYLETAALL 914

  Fly  1398 LEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVKY 1462
            |||||||...:..|.|||..||..||..:|..|.:..:.:..||...:|||||||..|||.||||
Zfish   915 LEFGADVDGVSESGLTPLGYAAAAGHLSIVTALCSKKAKVDHLDKNGQCALVHAALRGHLEVVKY 979

  Fly  1463 LLACDWSPRPHSQDV---TRSVALQQALIGAAAQAHCKILEDLLDL----NETEFDLDVNGMEPS 1520
            |:.|:|:  ...|.|   ::|.|:|||||.||:..:.:|:..||||    .|.|....:|..:..
Zfish   980 LVQCEWN--TDGQQVGSFSKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEEERAQINNFDTL 1042

  Fly  1521 SGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEPL 1585
            .||.||||||..|.:||..:||.:||.:...||:|...|:.||::|||.:|:.||..||.::...
Zfish  1043 WGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGIVPLFSAVRQGHWQIVDLLLNHGADVNMAD 1107

  Fly  1586 GQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHH 1650
            .|.| ||||:||.||||...:.|||:||.....|.||.||||||||:|||...:.|:|.|....|
Zfish  1108 KQGR-TPLMMAASEGHLGTAEFLLAQGASLSLMDKEGLTALSWACLKGHLPLVRALVERGAATAH 1171

  Fly  1651 EDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGAKL- 1714
            .|.:|||.|||||:.|.:.:|.::::.|..:||:|..||||||||:.|||...|...|:||||: 
Zfish  1172 ADKSGRTPLDLAAFYGDSEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVALLKKGAKIG 1236

  Fly  1715 ---------GPTTWSMAMGKPEILVILLNKLLEDGNVLYRKNRFQEAAHRYQYALRKISGLEQLL 1770
                     ||.||:||..||:|:::||:||:|:|:..|:|.:.:|||.||||||:|.. .|...
Zfish  1237 CQTLPTRARGPATWAMATSKPDIMIVLLSKLIEEGDGFYKKGKVKEAAQRYQYALKKFP-REGFT 1300

  Fly  1771 ERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMELGALNEAL 1835
            |....|.:|:.:||||||||:||:|:...:.:.|::|:..||.|||.|||||:|:......:.||
Zfish  1301 EDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFASKALELKPKSYEAYYARARAKRSSRQFHAAL 1365

  Fly  1836 VDANEAMQQAAQSGVLC----EVVEVLKRIQTE 1864
            .|.:||::       ||    |:..:|:|::.|
Zfish  1366 EDLSEAVR-------LCPNNREIQRLLQRVEEE 1391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rolsNP_729778.1 zf-RING_5 327..364 CDD:291308
Ank_5 1363..1418 CDD:290568 27/54 (50%)
ANK 1378..1503 CDD:238125 59/127 (46%)
ANK repeat 1382..1408 CDD:293786 15/25 (60%)
ANK repeat 1410..1441 CDD:293786 10/30 (33%)
Ank_2 1415..1552 CDD:289560 60/143 (42%)
ANK 1486..1609 CDD:238125 54/126 (43%)
ANK repeat 1486..1518 CDD:293786 13/35 (37%)
ANK repeat 1521..1552 CDD:293786 15/30 (50%)
Ank_2 1526..1619 CDD:289560 43/92 (47%)
ANK 1549..1675 CDD:238125 60/125 (48%)
ANK repeat 1554..1586 CDD:293786 12/31 (39%)
ANK repeat 1591..1619 CDD:293786 15/27 (56%)
Ank_2 1593..1685 CDD:289560 45/91 (49%)
ANK repeat 1621..1652 CDD:293786 17/30 (57%)
ANK repeat 1654..1685 CDD:293786 13/30 (43%)
Ank_2 1659..1735 CDD:289560 39/85 (46%)
ANK repeat 1687..1712 CDD:293786 14/24 (58%)
TPR_11 1736..1812 CDD:290150 32/75 (43%)
TPR repeat 1736..1768 CDD:276809 15/31 (48%)
TPR repeat 1773..1810 CDD:276809 15/36 (42%)
TPR_11 1783..1843 CDD:290150 29/59 (49%)
TPR repeat 1815..1843 CDD:276809 13/27 (48%)
tanc2aXP_021329165.1 ANKYR 811..982 CDD:223738 82/170 (48%)
ANK repeat 899..925 CDD:293786 15/25 (60%)
ANK 922..1130 CDD:238125 89/210 (42%)
ANK repeat 927..958 CDD:293786 10/30 (33%)
Ank_2 1012..1107 CDD:315466 37/94 (39%)
ANK repeat 1044..1074 CDD:293786 15/29 (52%)
ANK 1074..1196 CDD:238125 60/122 (49%)
ANK repeat 1076..1107 CDD:293786 12/30 (40%)
ANK repeat 1110..1140 CDD:293786 16/30 (53%)
ANK 1140..1264 CDD:238125 59/123 (48%)
ANK repeat 1142..1173 CDD:293786 17/30 (57%)
ANK repeat 1175..1206 CDD:293786 13/30 (43%)
ANK repeat 1208..1238 CDD:293786 17/29 (59%)
TPR <1260..1398 CDD:223533 57/140 (41%)
TPR repeat 1267..1292 CDD:276809 13/24 (54%)
TPR repeat 1297..1340 CDD:276809 17/42 (40%)
TPR repeat 1345..1373 CDD:276809 13/27 (48%)
Atrophin-1 <1402..1802 CDD:331285
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BH8T
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 858 1.000 Inparanoid score I412
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1073736at2759
OrthoFinder 1 1.000 - - FOG0003165
OrthoInspector 1 1.000 - - otm24771
orthoMCL 1 0.900 - - OOG6_105209
Panther 1 1.100 - - O PTHR24166
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5649
SonicParanoid 1 1.000 - - X1834
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1211.860

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