DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rols and ankrd52b

DIOPT Version :9

Sequence 1:NP_729778.1 Gene:rols / 39368 FlyBaseID:FBgn0041096 Length:1900 Species:Drosophila melanogaster
Sequence 2:XP_693039.6 Gene:ankrd52b / 564614 ZFINID:ZDB-GENE-121105-6 Length:632 Species:Danio rerio


Alignment Length:669 Identity:167/669 - (24%)
Similarity:255/669 - (38%) Gaps:180/669 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1340 NISSSLGALRNVYSPNLKVSRLVLLAGASPN----------HRTDYMGGAPILCIAAHEG----- 1389
            |||.....::.|:|.|.::...:|......|          |...::|||.|:.:....|     
Zfish     5 NISEQSLLVQAVFSQNAEMLEFLLEQNEDVNELDQECRSALHAAAFVGGAHIMDLLISSGANVNA 69

  Fly  1390 -----ILPM-----------VSLLLEFGADVGLTNSQGC-TPLILAAMRGHCDVVRPLVAAGSSL 1437
                 :.|:           |.||:|.||||. |..:.| |||.:||.......|..|:...|||
Zfish    70 KDQEWLTPLHRAAASQNEVSVGLLMEKGADVN-TQDRFCQTPLHVAAANRATKCVDVLLFHESSL 133

  Fly  1438 GQLDITQRCALVHAARMGHLSVVKYLLACDWSPRPHSQDVTRSVALQQALIGAAAQAHCKILEDL 1502
            ...|...|.||.||...||...|..||      ...:....|.:..:|.|..||...:.::::.|
Zfish   134 NAADCFGRTALHHAVHSGHTETVAVLL------NKGANVSARDIKDRQPLHLAAFLGNMEVVKLL 192

  Fly  1503 LDLNETEFDLDVNGMEPSSGELALT---AAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVK 1564
            |     .|..||:..:    :||.|   |||.....:|:..||..|||||..:..|.:||.:...
Zfish   193 L-----AFRADVSCRD----KLAFTPLHAAALGEHTEVLKYLLKHGAQIDEADGSGNTALHMVCS 248

  Fly  1565 EGHWSVVEHLLQRGALLDEPLGQTRKTPLMIAAE--EGHLELVDLLLARGAQREAQDHEGFTALS 1627
            .|..|||..|:..||.::.| .....|||.:.||  :|.| .::||:..||.....::||.:.|.
Zfish   249 AGLESVVCDLVNCGADVNRP-NLRGSTPLHLCAESPDGAL-CLELLVNNGAHVNIPNNEGKSPLH 311

  Fly  1628 WACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPL 1692
            .|.:.||...::.||::|......|:.|.|||..||..|...|:..:|..|.::....:.||.||
Zfish   312 MAAIHGHFTRSQILIQNGAEVECVDNYGNTALHTAAKHGHELLISELLNNGADIARRGIDGMTPL 376

  Fly  1693 DRAI--------------------------AC-------RNIQAVQVFLRKGA------KLG--P 1716
            ..|:                          .|       .|::.:::.|..||      .:|  |
Zfish   377 HLAVLYGYSDCCLKLLTSGFDINTLDGLSRTCLHIAASGGNVECLKLLLDSGADWSIKDNIGRTP 441

  Fly  1717 TTWSMAMGKPEILVILLNKLLEDGNVLYRKNRFQEAAHRYQYALRKISGLEQLLERNAIFAQLRT 1781
            ...|...|....||:.|:...:..:|        :.|.|........:|....:|          
Zfish   442 LHASAYSGSVSALVLALSCASDVDSV--------DDAGRSALMFAAENGHTSAVE---------- 488

  Fly  1782 NLLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMELGAL-------NEALVDA- 1838
             :||:.:|....|.  |.:::.|.....::.|             |:.||       :.:|:.: 
Zfish   489 -ILLHEARADLSLQ--DVNMNSALHLACRRGH-------------EMCALLMLAETDDTSLISST 537

  Fly  1839 NEAMQQ----AAQSGVLCEVVEVLKRIQTELLTR----ISISSEDQT------------------ 1877
            |.|:|.    ||::| |..||||       ||||    :::..:..|                  
Zfish   538 NRALQTPLHIAARNG-LVTVVEV-------LLTRGATVLAVDEDGHTPALACAPNKEVAKCLALI 594

  Fly  1878 --------GRMSNIGGGAS 1888
                    |.|.|.|.|.|
Zfish   595 ISTMKPFIGLMKNCGSGVS 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rolsNP_729778.1 zf-RING_5 327..364 CDD:291308
Ank_5 1363..1418 CDD:290568 22/86 (26%)
ANK 1378..1503 CDD:238125 41/146 (28%)
ANK repeat 1382..1408 CDD:293786 10/46 (22%)
ANK repeat 1410..1441 CDD:293786 11/31 (35%)
Ank_2 1415..1552 CDD:289560 43/139 (31%)
ANK 1486..1609 CDD:238125 41/127 (32%)
ANK repeat 1486..1518 CDD:293786 8/31 (26%)
ANK repeat 1521..1552 CDD:293786 14/33 (42%)
Ank_2 1526..1619 CDD:289560 34/97 (35%)
ANK 1549..1675 CDD:238125 41/127 (32%)
ANK repeat 1554..1586 CDD:293786 11/31 (35%)
ANK repeat 1591..1619 CDD:293786 11/29 (38%)
Ank_2 1593..1685 CDD:289560 29/93 (31%)
ANK repeat 1621..1652 CDD:293786 9/30 (30%)
ANK repeat 1654..1685 CDD:293786 10/30 (33%)
Ank_2 1659..1735 CDD:289560 24/116 (21%)
ANK repeat 1687..1712 CDD:293786 8/57 (14%)
TPR_11 1736..1812 CDD:290150 11/75 (15%)
TPR repeat 1736..1768 CDD:276809 4/31 (13%)
TPR repeat 1773..1810 CDD:276809 6/36 (17%)
TPR_11 1783..1843 CDD:290150 13/67 (19%)
TPR repeat 1815..1843 CDD:276809 6/35 (17%)
ankrd52bXP_693039.6 ANK <5..61 CDD:295348 13/55 (24%)
ANK repeat 7..38 CDD:293786 6/30 (20%)
Ank_2 12..104 CDD:289560 21/92 (23%)
ANK 35..160 CDD:238125 37/125 (30%)
ANK repeat 40..71 CDD:293786 6/30 (20%)
ANK repeat 76..104 CDD:293786 10/28 (36%)
Ank_2 78..170 CDD:289560 31/98 (32%)
ANK 101..226 CDD:238125 40/140 (29%)
ANK repeat 108..137 CDD:293786 10/28 (36%)
ANK repeat 139..170 CDD:293786 10/36 (28%)
Ank_2 144..236 CDD:289560 32/106 (30%)
ANK repeat 172..203 CDD:293786 9/35 (26%)
ANK repeat 205..236 CDD:293786 14/30 (47%)
Ank_5 225..278 CDD:290568 21/53 (40%)
ANK 233..359 CDD:238125 41/127 (32%)
ANK repeat 238..269 CDD:293786 11/31 (35%)
ANK repeat 271..303 CDD:293786 11/32 (34%)
Ank_2 276..368 CDD:289560 29/92 (32%)
ANK 300..425 CDD:238125 27/124 (22%)
ANK repeat 305..336 CDD:293786 9/30 (30%)
ANK repeat 338..369 CDD:293786 10/30 (33%)
Ank_2 343..435 CDD:289560 17/91 (19%)
ANK 371..491 CDD:238125 22/138 (16%)
ANK repeat 371..402 CDD:293786 5/30 (17%)
ANK repeat 404..435 CDD:293786 5/30 (17%)
ANK repeat 437..468 CDD:293786 8/38 (21%)
Ank_4 438..491 CDD:290365 12/71 (17%)
ANK 465..595 CDD:238125 32/171 (19%)
ANK repeat 470..502 CDD:293786 8/44 (18%)
Ank_2 475..571 CDD:289560 28/129 (22%)
ANK repeat 504..538 CDD:293786 6/46 (13%)
ANK repeat 540..571 CDD:293786 14/38 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1073736at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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