DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rols and ANKRD65

DIOPT Version :9

Sequence 1:	NP_729778.1	Gene:	rols / 39368	FlyBaseID:	FBgn0041096	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_001138682.1	Gene:	ANKRD65 / 441869	HGNCID:	42950	Length:	399	Species:	Homo sapiens

Alignment Length:	335	Identity:	101/335 - (30%)
Similarity:	145/335 - (43%)	Gaps:	49/335 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1385 AAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALV 1449
            |...|...:|:.||..||.|...:..|.|||.||.:|||..:||.|:..|:.:|.:|...|.||.
Human    48 AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALH 112

  Fly  1450 HAARMGHLSVVKYLLACDWSPRPHSQDVTRSVALQQALIGAAAQAHCKILEDLLDLNETEFDLDV 1514
            .||..||..|.:.||      :..:....||......|..|||..|..:...||:
Human   113 EAAWHGHSRVAELLL------QRGASAAARSGTGLTPLHWAAALGHTLLAARLLE---------- 161

  Fly  1515 NGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGA 1579
               .|..|    .|||                  :|.:.:|::|...|...|..:|:|.|...||
Human   162 ---APGPG----PAAA------------------EAEDARGWTAAHWAAAGGRLAVLELLAAGGA 201

  Fly  1580 LLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEH 1644
            .||        ..|::||..|....:..||||||:.:|:|..|.|||..|...|.....:.|:.|
Human   202 GLD--------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGH 258

  Fly  1645 GCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLR 1709
            |.:....|.:||:||..||.:|....|..::.||..::..|..|:.||..|....:::.....|.
Human   259 GADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323

  Fly  1710 KGAKLGPTTW 1719
            :||::..|.|
Human   324 RGAQVDATGW 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rols	NP_729778.1	zf-RING_5	327..364	CDD:291308
		Ank_5	1363..1418	CDD:290568	12/32 (38%)
		ANK	1378..1503	CDD:238125	40/117 (34%)
		ANK repeat	1382..1408	CDD:293786	8/22 (36%)
		ANK repeat	1410..1441	CDD:293786	14/30 (47%)
		Ank_2	1415..1552	CDD:289560	37/136 (27%)
		ANK	1486..1609	CDD:238125	28/122 (23%)
		ANK repeat	1486..1518	CDD:293786	7/31 (23%)
		ANK repeat	1521..1552	CDD:293786	5/30 (17%)
		Ank_2	1526..1619	CDD:289560	26/92 (28%)
		ANK	1549..1675	CDD:238125	42/125 (34%)
		ANK repeat	1554..1586	CDD:293786	11/31 (35%)
		ANK repeat	1591..1619	CDD:293786	11/27 (41%)
		Ank_2	1593..1685	CDD:289560	32/91 (35%)
		ANK repeat	1621..1652	CDD:293786	9/30 (30%)
		ANK repeat	1654..1685	CDD:293786	10/30 (33%)
		Ank_2	1659..1735	CDD:289560	17/61 (28%)
		ANK repeat	1687..1712	CDD:293786	5/24 (21%)
		TPR_11	1736..1812	CDD:290150
		TPR repeat	1736..1768	CDD:276809
		TPR repeat	1773..1810	CDD:276809
		TPR_11	1783..1843	CDD:290150
		TPR repeat	1815..1843	CDD:276809
ANKRD65	NP_001138682.1	ANK 1	40..69		8/20 (40%)
		ANK	<41..94	CDD:238125	19/45 (42%)
		Ank_2	45..136	CDD:289560	33/93 (35%)
		ANK repeat	45..71	CDD:293786	8/22 (36%)
		ANK	69..192	CDD:238125	44/163 (27%)
		ANK 2	73..102		13/28 (46%)
		ANK repeat	74..104	CDD:293786	14/29 (48%)
		ANK repeat	106..137	CDD:293786	10/36 (28%)
		ANK 3	106..135		10/34 (29%)
		ANK 4	139..168		9/45 (20%)
		Ank_2	144..299	CDD:289560	56/197 (28%)
		ANK 5	176..205		11/36 (31%)
		ANK 6	207..231		10/23 (43%)
		ANK 7	235..264		9/28 (32%)
		ANK	252..355	CDD:238125	24/82 (29%)
		ANK repeat	268..299	CDD:293786	10/30 (33%)
		ANK 8	268..297		10/28 (36%)
		Ank_2	273..364	CDD:289560	17/61 (28%)
		ANK repeat	301..332	CDD:293786	7/30 (23%)
		ANK 9	301..330		7/28 (25%)
		ANK repeat	334..364	CDD:293786	101/335 (30%)
		ANK 10	334..363		101/335 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..399
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149763
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24166
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030