Protein Alignment rols and tanc2b

DIOPT Version :10

• Sequence 1: NP_729778.1
• Gene: rols / 39368
• FlyBaseID: FBgn0041096
• Length: 1900
• Species: Drosophila melanogaster
• Sequence 2: XP_073774149.1
• Gene: tanc2b / 335127
• ZFINID: ZDB-GENE-030131-7067
• Length: 2164
• Species: Danio rerio
• Alignment Length: 1617
• Identity: 582/1617 - (35%)
• Similarity: 816/1617 - (50%)
• Gaps: 308/1617 - (19%)

  Fly   434 SNGKLPRAAALSTNGNGFTTGTTQTVTVDVHHQLGGGGG---------GAAAAAKQLMANG---- 485
            :.||..|.:.:|::|.....|..|:..:|..|...|.||         |..:.|......|
Zfish    11 TGGKANRKSRISSDGGNEDGGDLQSAALDPFHSYTGPGGSVDSDCVFEGGYSVAPLSATEGFQHM 75

  Fly   486 --ISGHSRSSSMSHNI-HAAAYSELSAAPPAFATPPTRRRFFNHKNLRSALTGGSGGGSGVGGGV 547
              :.|.|||...|..: |..:.|.|          |:.|:.|      |..|||.|...|....|
Zfish    76 RAMEGVSRSLPSSPLLTHQISSSHL----------PSARKIF------STATGGIGAELGPPPSV 124

  Fly   548 GGAGGVGGGHRRTASNGGCPIDTASILSGDHTHQHHHRDNQPEGKESNALNTSTCSDSAVTRRRR 612
            ..|...             .:.....|.||..         .||.|....:.....|
Zfish   125 DEAANT-------------LMTRLGFLLGDKV---------SEGSEEPQFSMEEPDD-------- 159

  Fly   613 KNVSNHNLKTSARHGASSENRLNRLSLAGTSVYAGHLSSLVFGKIKSLWSVNSSNSSE------A 671
                      :...|||                         |::....::.||.:|.      :
Zfish   160 ----------AQGFGAS-------------------------GRMSPCSTLTSSTASPPACSPCS 189

  Fly   672 GLNQLAGSDAIDHHSSFLNEKLQKDQLHARLGLL---------LNDPGSNGNSSSSGSGCEPISA 727
            .|...|...|:...:|.|.   .:|.     |::         ::..|.:|: .|.||..:...:
Zfish   190 TLPSAAPGQAVTSPTSTLE---SRDS-----GIIATLTNYSEPMDRSGKHGD-GSRGSSLKLWHS 245

  Fly   728 HSTTSTTSSSGVGAASTTTSGSSQNVSPEQTLASGAG------MLSGSQLSVATSHGVKEDALSL 786
            |.:|..:|...|. .:.|.|..|.|..||.:....:.      ::.......|||....||...|
Zfish   246 HRSTLDSSLYRVD-ENMTASTFSLNKIPEPSSVHYSSHPTPLYLMPRPNSVAATSSAHLEDLAYL 309

  Fly   787 CGKFKAGCSMLHVYEALPSKSRKGNVRRSTRGQQGSSSSASAASAV--GSRVTASSLAAVQLALK 849
            ..:..|   .|.....:|.:|       ||.|:.|....|||.|..  ...:..:......:|||
Zfish   310 DEQRHA---PLRTSLRMPRQS-------STAGRSGQDLRASANSHAWQSQSLRLAPYRLQDIALK 364

  Fly   850 PLFFEVPLQEPDPPYVGRQWLVQQLSNIL----LGTETRVVLINGQPGTGKTAFCLQLVEYSCFG 910
            ||.||||....|..:.||.||.|::...|    .|:...|||: |..|.||||...:||..||.|
Zfish   365 PLLFEVPSITMDSVFTGRDWLFQEIDACLRSTHSGSSAGVVLV-GNIGFGKTAIISRLVALSCHG 428

  Fly   911 RRQMQ---DDP-------DGI-YSQLQL------GAHC-----------ERMRGLASHMVGYHFC 947
            .|..|   |.|       ||| .||.|.      |..|           |.||.||:.:|.||:|
Zfish   429 NRMRQIASDSPQASPKHGDGIPLSQPQPSHGTLGGGSCPGTPEMRRRQEEAMRRLAAQVVAYHYC 493

  Fly   948 QADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSEPHLQDILSVRECIADAERVMKLAILEPL 1012
            |:|...||.||:|||::||.||::|||||||:.||.|||:|.:||:|.|:.|.....:..:||||
Zfish   494 QSDNAYTCLVPEFVHNVAALLCRSPQLTAYRELLLKEPHIQSMLSLRSCVQDPPTAFRRGVLEPL 558

  Fly  1013 AHLHRAGKI-PAKVAVIVVDALCEAEYHRPDHGHTIASFLAQLTPHFPAWLKLVATVRTQMLELV 1076
            ..|::..|| |.:..:|::|.|.|||:|:||:|.||.|||.:....||||||||.||||.:.|:.
Zfish   559 HALYKERKITPEEDLIILIDGLNEAEFHKPDYGDTIVSFLCKTINKFPAWLKLVVTVRTTLQEIT 623

  Fly  1077 KAPSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIRMNIG-GGGGQNSQSGSQPQTKFVSHLQ 1140
            |...:.|::||:...:.|:..|:..||..|:..|.||:.||. .|...||..|     |..|||:
Zfish   624 KPLPFHQISLDALEENDAIDHDLQGYILHRIHSSAEIQNNISLNGKMDNSSFG-----KLSSHLK 683

  Fly  1141 SLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSLAQIFLLHFNLRFPTARSFEQAAPILNICL 1205
            :||:||.||.||..|||.||.||:|||:|||:|||||:::||..|:||||..|||:|.|:||:.|
Zfish   684 ALSQGSFLYLKLTFDLIERGYLVLKSSNYKVVPVSLAEVYLLQCNMRFPTQSSFERALPLLNVGL 748

  Fly  1206 AALYPLTLDEIYYSMEALSHG--REALSWPDFMQRFKLLDGFLIKRLDNTYMFFHSSLREWLMRR 1268
            |:|:|||.::||   :|::.|  :..|.|.||.||.:.|..||:||.|.|.||.|.|.||||:.|
Zfish   749 ASLHPLTDEQIY---QAINGGSVKGTLDWDDFQQRMENLSVFLVKRRDGTRMFVHPSFREWLIWR 810

  Fly  1269 DEGESNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLELGHHMLKAHLYGGTSLTL-LSPRDLQSY 1332
            :|||..|||||.|.||..:||..||.:..|:.|.|:|||||:||||::.|.|..: :|...||..
Zfish   811 EEGEKTKFLCDPRNGHTLLAFWFSRQENKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGL 875

  Fly  1333 WLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASPNHRTDYMGGAPILCIAAHEGILPMVSLL 1397
            |::.:.:::|::|.:|||:|:||:|||||::|.||:.|:||:.:..||:||:.||.|...||:||
Zfish   876 WVSYSTESLSTALSSLRNLYTPNIKVSRLLILGGANVNYRTEVLNNAPVLCVHAHLGYADMVNLL 940

  Fly  1398 LEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVKY 1462
            ||.||.|...:..|.|||..||..||..:|..|....:.|..||...:|||||||..|||.|:|:
Zfish   941 LENGAGVDSPSESGLTPLGYAAAAGHLSIVTSLCKRKAKLDHLDKHGQCALVHAALRGHLDVLKF 1005

  Fly  1463 LLACDW------SPRP-HSQDV------------------------------------------- 1477
            |:..||      ||.| .|||.
Zfish  1006 LIQNDWGQTHLQSPSPTQSQDTPSPVSQPQATPSPTPPDATPSPTQATPTESPPSGPEQQEDPAE 1070

  Fly  1478 --------------------------------------TRSVALQQALIGAAAQAHCKILEDLLD 1504
                                                  .:|:|:|||||.||:..:.:|:..|||
Zfish  1071 TPQEEEQNREESPKEEVEKQTQEDTQAERSSSPSSVSFNKSIAIQQALIAAASMGYTEIVSYLLD 1135

  Fly  1505 LNE-TEFDL---DVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKE 1565
            |.| .|.|:   .:|..:...||.||:|||..|.::|..:||.:|:.:...||:|...|:.:|::
Zfish  1136 LPERDEEDIQRAQINSCDTLWGETALSAAAGRGKLEVCRLLLEQGSAVAQPNRRGVLPLFSSVRQ 1200

  Fly  1566 GHWSVVEHLLQRGALLDEPLGQTR-KTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWA 1629
            |||.:|:.|:..||  |..|...: :||||:||.||||:.|:.|:|:||..:..|.||.||||||
Zfish  1201 GHWQIVDLLVSHGA--DVNLADKQGRTPLMMAASEGHLDTVEFLMAQGASMDLMDKEGLTALSWA 1263

  Fly  1630 CLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDR 1694
            ||:|||:..:.|:|.|....|.|.||||.|||||:.|.:.:|.::::.|..:||:|..|||||||
Zfish  1264 CLKGHLSVVRCLVERGAATDHADKNGRTPLDLAAFYGDSDVVQFLVDHGALVEHVDYSGMRPLDR 1328

  Fly  1695 AIACRNIQAVQVFLRKGAKL-----------GPTTWSMAMGKPEILVILLNKLLEDGNVLYRKNR 1748
            |:.|||...|...|:||||:           ||.||:||..||:|::|||:||||:|:..|:|.:
Zfish  1329 AVGCRNTSVVVALLKKGAKIGCQTLPSPHKGGPATWAMATSKPDIMIILLSKLLEEGDGFYKKGK 1393

  Fly  1749 FQEAAHRYQYALRKI--SGLEQLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAIAQK 1811
            .:|||.||||||:|.  .||.:.|:   .|.:|:.:|.||||||:||:|:...:.:.||:|:..|
Zfish  1394 VKEAAQRYQYALKKFPREGLSEDLK---TFKELKVSLFLNLSRCRRKMNDFGMAEEFATKALELK 1455

  Fly  1812 PHSYEGYYARAKARMELGALNEALVDANEAMQQAAQSGVLC----EVVEVLKRIQTE 1864
            |.|||.:||||:|:.......|||.|..||::       ||    |:..:|:|::.|
Zfish  1456 PKSYEAFYARARAKRSSRQFAEALDDLREAIK-------LCPNNREIQRLLQRVEEE 1505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rols	NP_729778.1	zf-RING_5	327..364	CDD:434085
		Ank_2	1382..1467	CDD:463710	40/84 (48%)
		ANK repeat	1382..1408	CDD:293786	14/25 (56%)
		ANK repeat	1410..1441	CDD:293786	11/30 (37%)
		ANKYR	1481..1714	CDD:440430	108/237 (46%)
		ANK repeat	1486..1518	CDD:293786	14/35 (40%)
		ANK repeat	1521..1552	CDD:293786	12/30 (40%)
		ANK repeat	1554..1586	CDD:293786	11/31 (35%)
		ANK repeat	1591..1619	CDD:293786	15/27 (56%)
		Spy	1608..>1847	CDD:443119	118/251 (47%)
		ANK repeat	1621..1652	CDD:293786	17/30 (57%)
		ANK repeat	1654..1685	CDD:293786	14/30 (47%)
		ANK repeat	1687..1712	CDD:293786	14/24 (58%)
		TPR repeat	1736..1768	CDD:276809	18/33 (55%)
		TPR repeat	1773..1810	CDD:276809	15/36 (42%)
		TPR repeat	1815..1843	CDD:276809	13/27 (48%)
tanc2b	XP_073774149.1	None