DRSC/TRiP Functional Genomics Resources

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Protein Alignment rols and Mphosph8

DIOPT Version :9

Sequence 1:NP_729778.1 Gene:rols / 39368 FlyBaseID:FBgn0041096 Length:1900 Species:Drosophila melanogaster
Sequence 2:NP_001017375.2 Gene:Mphosph8 / 290270 RGDID:1305133 Length:851 Species:Rattus norvegicus


Alignment Length:339 Identity:75/339 - (22%)
Similarity:122/339 - (35%) Gaps:120/339 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1503 LDLNETEFDLDVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGH 1567
            |:.|| |::||   .|.|:|...:..||..|..|::.:|:::||:::.|.:.|            
  Rat   577 LNSNE-EYNLD---QEDSTGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNG------------ 625

  Fly  1568 WSVVEHLLQRGALLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLR 1632
                                  .|.|:.|||:..|..|.:||..||....|...|.|||..||.|
  Rat   626 ----------------------TTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKR 668

  Fly  1633 GHLAAAKTLIEHG--CNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNL---EHIDVHGMRPL 1692
            |:....:.:||.|  ||            .|:.:|.:|   :|..:|..|:   |.:..| :..|
  Rat   669 GNSDIVRLVIECGADCN------------ILSKHQNSA---LYFAKQCNNVLVYELLKSH-LETL 717

  Fly  1693 DRA---------------------IACRNI---------------------QAVQVFLRKGAKLG 1715
            .|.                     |||..:                     ..|.:|:.....||
  Rat   718 SRVAEETIRDYFESRLALLEPVFPIACHRLCEGPDFSTDFNYMPPQNMPEGSGVLLFIFHANFLG 782

  Fly  1716 PTTWSMAMGKPEILVILLNKLLEDGNVLYRKNRFQEAA---HRYQYALRKISGLEQLLER--NAI 1775
            ....:...|...:..::||            ::||...   ..:.|:...::|..:|..|  .|.
  Rat   783 KDVIARLCGPCSVQAVVLN------------DKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAP 835

  Fly  1776 FAQLRTNLLLNLSR 1789
            ||:::  ||:...|
  Rat   836 FAKVK--LLIGAYR 847

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rolsNP_729778.1 zf-RING_5 327..364 CDD:291308
Ank_5 1363..1418 CDD:290568
ANK 1378..1503 CDD:238125 75/339 (22%)
ANK repeat 1382..1408 CDD:293786
ANK repeat 1410..1441 CDD:293786
Ank_2 1415..1552 CDD:289560 16/48 (33%)
ANK 1486..1609 CDD:238125 25/105 (24%)
ANK repeat 1486..1518 CDD:293786 6/14 (43%)
ANK repeat 1521..1552 CDD:293786 8/30 (27%)
Ank_2 1526..1619 CDD:289560 20/92 (22%)
ANK 1549..1675 CDD:238125 31/127 (24%)
ANK repeat 1554..1586 CDD:293786 1/31 (3%)
ANK repeat 1591..1619 CDD:293786 11/27 (41%)
Ank_2 1593..1685 CDD:289560 31/96 (32%)
ANK repeat 1621..1652 CDD:293786 13/32 (41%)
ANK repeat 1654..1685 CDD:293786 7/33 (21%)
Ank_2 1659..1735 CDD:289560 19/120 (16%)
ANK repeat 1687..1712 CDD:293786 8/66 (12%)
TPR_11 1736..1812 CDD:290150 12/59 (20%)
TPR repeat 1736..1768 CDD:276809 4/34 (12%)
TPR repeat 1773..1810 CDD:276809 6/17 (35%)
TPR_11 1783..1843 CDD:290150 3/7 (43%)
TPR repeat 1815..1843 CDD:276809
Mphosph8NP_001017375.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 21..54
CHROMO 58..109 CDD:214605
Histone H3K9me3 binding. /evidence=ECO:0000250|UniProtKB:Q99549 80..87
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 133..174
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 315..428
ANK 586..710 CDD:238125 45/175 (26%)
ANK 1 591..620 8/28 (29%)
ANK repeat 594..622 CDD:293786 7/27 (26%)
Ank_2 597..686 CDD:289560 34/134 (25%)
ANK repeat 624..655 CDD:293786 12/64 (19%)
ANK 2 624..653 12/62 (19%)
ANK repeat 657..686 CDD:293786 13/40 (33%)
ANK 3 657..686 13/40 (33%)
ANK 4 690..719 8/32 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24166
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.100

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