DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rols and TANC2

DIOPT Version :9

Sequence 1:	NP_729778.1	Gene:	rols / 39368	FlyBaseID:	FBgn0041096	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	XP_011522899.1	Gene:	TANC2 / 26115	HGNCID:	30212	Length:	2075	Species:	Homo sapiens

Alignment Length:	1467	Identity:	554/1467 - (37%)
Similarity:	786/1467 - (53%)	Gaps:	215/1467 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   591 GKESNALNTSTCSDSAVTRRRRKNVSNHNLKTSARHGASSEN----------------------- 632
            |.:|:..|.|:...|.....||::..:.....|.:.|.|:|:
Human    12 GGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGMQHIR 76

  Fly   633 ---RLNRLSLAGTSVYAGHLSSLVFGKIKSLWS-------VNSSN--SSEAGLNQLAGSDAIDHH 685
               .::| ||..:.:......|:....:|.|.:       |.|..  .||.|...|..:..:|..
Human    77 IMEGMSR-SLPSSPLLTHQSISVRLQPVKKLTAPLRKAKFVESPRIPESELGSPTLTSAQKLDVD 140

  Fly   686 SSFLNEKLQK-----------DQLHARLGLLLND------PG----------------------- 710
            :....:..|:           :.|..|||.||.:      ||
Human   141 AYCPGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPC 205

  Fly   711 ----SNGNSSSSGSGCE---PISAHST------------TSTTSSSGVGAASTTTS--------- 747
                |:..|..:.|.|.   |||.::|            |||..|...|..:|.||
Human   206 STLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSGIIATLTSYSENVERTK 270

  Fly   748 ---------GSSQNVSPEQTLAS------------------GAGMLSGSQLSVATSHGVKEDALS 785
                     ||..|:.|.|:..|                  ....:....|....|..|:...|.
Human   271 YAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLY 335

  Fly   786 LCGK--FKAGCSMLHVYE-ALPSKSRKGNVRRSTRGQQGSSSSASAASAVGSRVTASSLAAVQLA 847
            |..:  ..|..|..|:.: |...:.|...:|.|.|..:.|...|.....:  ||..:......::
Human   336 LMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDL--RVRFAPYRPPDIS 398

  Fly   848 LKPLFFEVPLQEPDPPYVGRQWLVQQLSNILLGTETRV---VLINGQPGTGKTAFCLQLVEYSCF 909
            ||||.||||....:..:|||.|:..::...|..:...|   |:|.|..|.||||...:||..||.
Human   399 LKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCH 463

  Fly   910 GRRQMQ---------------------DDPDGIYSQLQLGAHC-----------ERMRGLASHMV 942
            |.|..|                     ..|...:|.:..|: |           |.||.|||.:|
Human   464 GTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGS-CPGTPEMRRRQEEAMRRLASQVV 527

  Fly   943 GYHFCQADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSEPHLQDILSVRECIADAERVMKLA 1007
            .||:||||...||.||:|||::||.||::|||||||:.||.|||||.:||:|.|:.|.....:..
Human   528 AYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRG 592

  Fly  1008 ILEPLAHLHRAGKIPAKVAVIVVDALCEAEYHRPDHGHTIASFLAQLTPHFPAWLKLVATVRTQM 1072
            :||||.:||:..|||.:..:|::|.|.|||:|:||:|.||.|||:::...||:||||:.||||.:
Human   593 VLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSL 657

  Fly  1073 LELVKAPSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIRMNIG-GGGGQNSQSGSQPQTKFV 1136
            .|:.|...:.::.||....::|:.||:..||..|:..|.||:.||. .|...|:..|     |..
Human   658 QEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFG-----KLS 717

  Fly  1137 SHLQSLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSLAQIFLLHFNLRFPTARSFEQAAPIL 1201
            |||::||:||.||.||..|||.:|.||:|||||||:||||::::||..|::|||..||::..|:|
Human   718 SHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLL 782

  Fly  1202 NICLAALYPLTLDEIYYSMEALS-HGREALSWPDFMQRFKLLDGFLIKRLDNTYMFFHSSLREWL 1265
            |:.:|:|:|||.:.|:.::.|.| .|  .|.|.||.||.:.|..|||||.|.|.||.|.|.||||
Human   783 NVAVASLHPLTDEHIFQAINAGSIEG--TLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWL 845

  Fly  1266 MRRDEGESNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLELGHHMLKAHLYGGTSLTL-LSPRDL 1329
            :.|:|||..|||||.|.||..:||..||.:..|:.|.|:|||||:||||::.|.|..: :|...|
Human   846 IWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSIL 910

  Fly  1330 QSYWLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASPNHRTDYMGGAPILCIAAHEGILPMV 1394
            |..|::.:.:.:|.:|.:|||:|:||:|||||::|.||:.|:||:.:..|||||:.:|.|...||
Human   911 QGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMV 975

  Fly  1395 SLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSV 1459
            :|||||||:|..::..|.|||..||..|:..:|..|....:.:..||...:|||||||..|||.|
Human   976 ALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEV 1040

  Fly  1460 VKYLLACDWSPRPHSQDV-TRSVALQQALIGAAAQAHCKILEDLLDLNETEFD----LDVNGMEP 1519
            ||:|:.|||:.....|.| .:|.|:|||||.||:..:.:|:..||||.|.:.:    ..:|..:.
Human  1041 VKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDS 1105

  Fly  1520 SSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEP 1584
            ..||.||||||..|.::|..:||.:||.:...||:|...|:..|::|||.:|:.||..||.::..
Human  1106 LWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMA 1170

  Fly  1585 LGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRH 1649
            ..|.| ||||:||.||||..||.|||:||.....|.||.||||||||:|||:..::|:::|....
Human  1171 DKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1234

  Fly  1650 HEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGAKL 1714
            |.|.||||.|||||:.|.|.:|.::::.|..:||:|..||||||||:.|||...|...|:||||:
Human  1235 HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1299

  Fly  1715 ----------GPTTWSMAMGKPEILVILLNKLLEDGNVLYRKNRFQEAAHRYQYALRKI--SGLE 1767
                      ||.||:||..||:|::|||:||:|:|::.|:|.:.:|||.||||||:|.  .|..
Human  1300 GCQTLPSRPRGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFG 1364

  Fly  1768 QLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKA-RMELGAL 1831
            :.|:   .|.:|:.:||||||||:||:|:...:.:.||:|:..||.|||.|||||:| |......
Human  1365 EDLK---TFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSSRQF 1426

  Fly  1832 NEALVDANEAMQQAAQSGVLC----EVVEVLKRIQTE 1864
            ..||.|.|||::       ||    |:..:|.|::.|
Human  1427 AAALEDLNEAIK-------LCPNNREIQRLLLRVEEE 1456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rols	NP_729778.1	zf-RING_5	327..364	CDD:291308
		Ank_5	1363..1418	CDD:290568	27/54 (50%)
		ANK	1378..1503	CDD:238125	57/125 (46%)
		ANK repeat	1382..1408	CDD:293786	14/25 (56%)
		ANK repeat	1410..1441	CDD:293786	9/30 (30%)
		Ank_2	1415..1552	CDD:289560	57/141 (40%)
		ANK	1486..1609	CDD:238125	53/126 (42%)
		ANK repeat	1486..1518	CDD:293786	12/35 (34%)
		ANK repeat	1521..1552	CDD:293786	14/30 (47%)
		Ank_2	1526..1619	CDD:289560	43/92 (47%)
		ANK	1549..1675	CDD:238125	62/125 (50%)
		ANK repeat	1554..1586	CDD:293786	11/31 (35%)
		ANK repeat	1591..1619	CDD:293786	17/27 (63%)
		Ank_2	1593..1685	CDD:289560	48/91 (53%)
		ANK repeat	1621..1652	CDD:293786	16/30 (53%)
		ANK repeat	1654..1685	CDD:293786	15/30 (50%)
		Ank_2	1659..1735	CDD:289560	41/85 (48%)
		ANK repeat	1687..1712	CDD:293786	14/24 (58%)
		TPR_11	1736..1812	CDD:290150	33/77 (43%)
		TPR repeat	1736..1768	CDD:276809	16/33 (48%)
		TPR repeat	1773..1810	CDD:276809	16/36 (44%)
		TPR_11	1783..1843	CDD:290150	32/60 (53%)
		TPR repeat	1815..1843	CDD:276809	15/28 (54%)
TANC2	XP_011522899.1	AAA_16	415..>457	CDD:289934	14/41 (34%)
		Ank_4	962..1011	CDD:290365	23/48 (48%)
		ANK repeat	963..989	CDD:293786	14/25 (56%)
		ANK	986..1194	CDD:238125	87/208 (42%)
		ANK repeat	991..1022	CDD:293786	9/30 (30%)
		Ank_2	996..1132	CDD:289560	55/135 (41%)
		ANK repeat	1108..1138	CDD:293786	14/29 (48%)
		Ank_2	1112..1204	CDD:289560	43/92 (47%)
		ANK repeat	1140..1171	CDD:293786	11/30 (37%)
		ANK	1168..1293	CDD:238125	65/125 (52%)
		ANK repeat	1174..1204	CDD:293786	18/30 (60%)
		Ank_2	1178..1270	CDD:289560	48/91 (53%)
		ANK repeat	1206..1237	CDD:293786	16/30 (53%)
		ANK repeat	1239..1270	CDD:293786	15/30 (50%)
		ANK repeat	1272..1302	CDD:293786	17/29 (59%)
		TPR_11	1331..1406	CDD:290150	33/77 (43%)
		TPR repeat	1331..1356	CDD:276809	13/24 (54%)
		TPR repeat	1361..1404	CDD:276809	18/45 (40%)
		TPR_11	1377..1441	CDD:290150	33/70 (47%)
		TPR repeat	1409..1438	CDD:276809	15/28 (54%)
		TFIIA	1487..>1714	CDD:281188
		ANAPC1	<1512..1583	CDD:289618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	441	1.000	Domainoid score	I552
eggNOG	1	0.900	-	-		E33208_3BH8T
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	871	1.000	Inparanoid score	I418
Isobase	1	0.950	-	0	Normalized mean entropy	S5183
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073736at2759
OrthoFinder	1	1.000	-	-		FOG0003165
OrthoInspector	1	1.000	-	-		otm41841
orthoMCL	1	0.900	-	-		OOG6_105209
Panther	1	1.100	-	-	O	PTHR24166
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5649
SonicParanoid	1	1.000	-	-		X1834
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810