DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rols and T28D6.4

DIOPT Version :9

Sequence 1:	NP_729778.1	Gene:	rols / 39368	FlyBaseID:	FBgn0041096	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	NP_499461.1	Gene:	T28D6.4 / 176566	WormBaseID:	WBGene00012124	Length:	991	Species:	Caenorhabditis elegans

Alignment Length:	1072	Identity:	216/1072 - (20%)
Similarity:	369/1072 - (34%)	Gaps:	326/1072 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   868 QWLVQQLSNILLGTETRVVLINGQPGTGKTAFCLQLVEYSCFGRRQMQDDPDGIYSQLQLGAHCE 932
            :|..|        ..:|.:.|.|:..:|||.|..:|.|
Worm    28 EWFQQ--------ANSRRLEIIGKEHSGKTWFARKLSE--------------------------- 57

  Fly   933 RMRGLASHMVGYHFCQADANLTCQVPDFVHSLAAQLCQA-PQLTAYRDYLLSEPHLQDILSVREC 996
                 .|..|..|||..|...:.:.|..:.||..||.:. |.|..        |.|..:..:.:.
Worm    58 -----VSECVASHFCSHDEPQSSEPPTVIRSLGEQLMRRFPNLVL--------PRLTTVTLLEDT 109

  Fly   997 IADAERVMKLAILEPLAHLHRAGKIPAKVAVIVVDALCEAEYHRPDHGHTIASFLAQLTPHFPAW 1061
            ::..:..::|    ||..:...    :|...:|:|::.:.|      ...:...|.::   .|.|
Worm   110 VSALDHFLRL----PLETMPST----SKPVFLVIDSVEDEE------TQVLVEMLVEI---LPPW 157

  Fly  1062 LKLVATVR------TQMLEL-----------VKAP-----SYTQLTLDSWASSQALQQ------- 1097
            :::|.|.|      |::|||           :|.|     ...:.:..||...:.|.:
Worm   158 IQIVTTSRDRTNSETELLELHIDSDFDKFIRLKLPHCHVEEVREASDGSWFYVEQLARAVELGMV 222

  Fly  1098 --DMLDYIG-------------------ARLADSPEIRMN------------------------- 1116
              ||:..||                   .|||.:...|..
Worm   223 PSDMVPPIGVEKMMHLVARSLPRSFADIVRLAKTSRNRPTRQQLLAVSQMLVSRDISVLEKDIRI 287

  Fly  1117 ----IGGGGGQN---------------SQSGSQPQTKFVSHLQSLSRGSM--------------- 1147
                ||....:|               .:...:..|.:..|.::..|.|.
Worm   288 ITSLIGTASSENPSEIFHVPDIWFQLIGEENFRCHTAWAEHYKTKRRKSAQDICELAYHLSHSTT 352

  Fly  1148 --LYAKLILDLIARGQLVIKSSSYKVLPVSLAQIFLLHFNLRFPTARSFEQAAPILNIC------ 1204
              |.|...|..:..|.||::.....:...:|         |:...||..|....::..|
Worm   353 NPLNAVKTLQSVGAGNLVLRCHVIDLPTTAL---------LKSAGARMEENNYDVVYACSVGDVS 408

  Fly  1205 -----LAALYPLTLDEIYYSMEALSHGREALSWPDFMQRFKLLDGFLIKRLDNTYMFFHSSLREW 1264
                 |..:.|:.:|..:..:.|.:.|...      |.|| |.|.|       .::...|...||
Worm   409 YLDAILREMKPVPMDICFGLLTAAARGNIE------MCRF-LADHF-------PHLVASSCCGEW 459

  Fly  1265 LMRRDEGESNKFLCDARL----------------GHAG-IAFRLSRLQAPLSP-QLTLELGHHML 1311
            ...|...      |..:|                ||:. .|.|.:.....|:. ||.|:.|..:.
Worm   460 NALRSAA------CYGQLEILHLLLEKGVDVDECGHSDRTALRAAAWSGQLAAVQLLLQTGAEVD 518

  Fly  1312 KAHLYGGTSL---TLLSPRDLQSYWLAGAAD-NISSSLGA------LRN--VYSPNLKVSRLVLL 1364
            :......|:|   ..:..:|:.|..:...|| |.....||      |.|  ....|.:.::|:|
Worm   519 RRDSEQRTALMAAAFMCHKDVVSVIIQYGADVNAIDKSGATALHLNLSNGSKQEENSETTKLLL- 582

  Fly  1365 AGASPNHRTDY----MGGAPILCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCD 1425
                 .|..|.    ..|...|.:||:.|. |.:.|:||....|.:.::.|.|||:|||.:|..:
Worm   583 -----EHNADCKIEDANGRVALHLAAYHGD-PCLQLILEKHPIVDVMDNMGQTPLMLAASQGQLE 641

  Fly  1426 VVRPLV-AAGSSLGQLDITQRCALVHAARMGHLSVVKYLLACDWSPRPHSQDVTRSVALQQALIG 1489
            .|:.|. .|.:.:..:|...|.||..||..||..||::|
Worm   642 AVQFLTKTAKADVDAIDNNGRTALQWAAINGHPEVVEFL-------------------------- 680

  Fly  1490 AAAQAHCKILEDLLDLNETEFDLDVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQ 1554
                  |.:..|             .|.:.:.|.:||..|..|..:::|..|.::.. ::|::|.
Worm   681 ------CSVGSD-------------EGHKDNDGAVALHYAVTHDHVELVKHLTNQHT-VEAKDRY 725

  Fly  1555 GYSALWLAVKEGHWSVVEHLLQRGALLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQD 1619
            |...:.:|...|:..|:|:|:....::::|..:.| |.|.:|:...|..::||:..|......:|
Worm   726 GQHPMMIAAANGNLKVLEYLMGISDIINQPDHEGR-TALSLASMAAHTSIIDLISPRITDWSQRD 789

  Fly  1620 HEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGG-NLEH 1683
            |:|........|...:..|:..:.||.|....|.:|||.:.:.|.....:....:...|| |.|.
Worm   790 HDGTPLAHTLILSNLIFVAEVYLGHGANSSDSDAHGRTCVHVVASTNDVAAAKMLKRIGGVNFEA 854

  Fly  1684 IDVHGMRPLDRAIACRNIQAVQVFL--------RKGAKLGPTTWSMA--MGKPEILVILLNKLLE 1738
            :|..|...|..|:..::: |:.|||        .:..:.|.|..|:|  :|..:    |:|.||:
Worm   855 VDRGGRTALMTAVWAKHV-AISVFLLDSCGVDPNRTDRQGATALSIAAQIGDRD----LVNLLLK 914

  Fly  1739 DGNVLYRKNRFQEAAHRYQYALRKISGLEQLL 1770
            .|    .:...:::..|....:..|||.|.::
Worm   915 FG----AEPEIKDSMGRTAMDVAMISGNEPIV 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rols	NP_729778.1	zf-RING_5	327..364	CDD:291308
		Ank_5	1363..1418	CDD:290568	17/58 (29%)
		ANK	1378..1503	CDD:238125	34/125 (27%)
		ANK repeat	1382..1408	CDD:293786	9/25 (36%)
		ANK repeat	1410..1441	CDD:293786	11/31 (35%)
		Ank_2	1415..1552	CDD:289560	30/137 (22%)
		ANK	1486..1609	CDD:238125	26/122 (21%)
		ANK repeat	1486..1518	CDD:293786	3/31 (10%)
		ANK repeat	1521..1552	CDD:293786	8/30 (27%)
		Ank_2	1526..1619	CDD:289560	22/92 (24%)
		ANK	1549..1675	CDD:238125	30/125 (24%)
		ANK repeat	1554..1586	CDD:293786	7/31 (23%)
		ANK repeat	1591..1619	CDD:293786	7/27 (26%)
		Ank_2	1593..1685	CDD:289560	23/92 (25%)
		ANK repeat	1621..1652	CDD:293786	6/30 (20%)
		ANK repeat	1654..1685	CDD:293786	8/31 (26%)
		Ank_2	1659..1735	CDD:289560	19/86 (22%)
		ANK repeat	1687..1712	CDD:293786	7/32 (22%)
		TPR_11	1736..1812	CDD:290150	8/35 (23%)
		TPR repeat	1736..1768	CDD:276809	7/31 (23%)
		TPR repeat	1773..1810	CDD:276809
		TPR_11	1783..1843	CDD:290150
		TPR repeat	1815..1843	CDD:276809
T28D6.4	NP_499461.1	Ank_2	428..521	CDD:372319	23/112 (21%)
		ANK repeat	428..454	CDD:293786	8/39 (21%)
		ANK repeat	459..488	CDD:293786	4/34 (12%)
		ANK repeat	490..521	CDD:293786	7/30 (23%)
		PHA03095	507..>776	CDD:222980	76/322 (24%)
		ANK repeat	523..554	CDD:293786	7/30 (23%)
		ANK repeat	556..592	CDD:293786	9/41 (22%)
		ANK repeat	594..624	CDD:293786	10/30 (33%)
		ANK repeat	626..658	CDD:293786	11/31 (35%)
		ANK repeat	660..691	CDD:293786	13/75 (17%)
		PHA03095	675..>943	CDD:222980	70/324 (22%)
		ANK repeat	725..756	CDD:293786	6/30 (20%)
		ANK repeat	824..856	CDD:293786	8/31 (26%)
		ANK repeat	858..890	CDD:293786	7/32 (22%)
		ANK repeat	892..923	CDD:293786	10/38 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073736at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920