DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rols and tanc2

DIOPT Version :9

Sequence 1:	NP_729778.1	Gene:	rols / 39368	FlyBaseID:	FBgn0041096	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	XP_031750132.1	Gene:	tanc2 / 100485280	XenbaseID:	XB-GENE-855813	Length:	2061	Species:	Xenopus tropicalis

Alignment Length:	1470	Identity:	561/1470 - (38%)
Similarity:	786/1470 - (53%)	Gaps:	221/1470 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   591 GKESNALNTST--CSDSAVTRRRRKNV-SNHNLKTSARHGASSEN--------RLNRL------- 637
            |.:||..|.|:  .|:.....||:.:| |.|.  .:|:.|:||||        .:|.|
Frog    12 GGKSNRKNRSSDGGSEELQESRRQHSVDSRHG--RAAQGGSSSENDCAFEPDYSINPLPVTEGMQ 74

  Fly   638 ----------SLAGTSVYAGHLSSLVFGKIKSLWS-------VNSSN--SSEAGLNQLAGSDAID 683
                      ||..:.:......|:....:|.|..       |.|..  .||.|...|..:..::
Frog    75 HIRMMEGMSRSLPSSPLLTHQAISVRLQPVKKLTDPLRKAKFVESPRIPESELGSPTLGSTQNLE 139

  Fly   684 HHSSFLNEKLQ-----------KDQLHARLGLLLND--------------PGSNGN-------SS 716
            ..:..|.|...           .:.|..|||.||.:              .|...|       ..
Frog   140 ADAYLLGEDESVLGPPPSVDEAANTLMTRLGFLLGEKVSEVQAAVPQYSMEGQEENQVREDWQED 204

  Fly   717 SSGSG-CEPISAHST-TSTTSSSGVGAASTT-----TSGSSQNVSPEQTLAS------------- 761
            ..||. .:.||..|| ||:|:|....:..:|     |:..:::.||..||.|
Frog   205 KQGSAVTQRISPCSTLTSSTASPPASSPCSTLPPPNTTAPAKDCSPTSTLESRDSGIIATLTSYS 269

  Fly   762 --------GA---------GMLSGSQ----------------------------LSVATSHGVKE 781
                    ||         |.:..:|                            |..|.|..|:.
Frog   270 ENMDRSKYGAESGKDGGTRGCVKQAQKSMDSCLYRVDENIMASTFSLNKIPERGLDTALSQSVQS 334

  Fly   782 DALSLCGK--FKAGCSMLHVYE-ALPSKSRKGNVRRSTRGQQGSSSSASAASAVGSRVTASSLAA 843
            ..|.|..:  ..|..|..|:.: |...:.|...:|.|.|  ....:.|...:....||..:....
Frog   335 IPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLR--MPRQTLAGPRTPQDLRVRFAPYRP 397

  Fly   844 VQLALKPLFFEVPLQEPDPPYVGRQWLVQQLSNILLGTE---TRVVLINGQPGTGKTAFCLQLVE 905
            ..::||||.||||....|..:|||.||..::...|...:   .|.|:|.|..|.||||...:||.
Frog   398 PDISLKPLLFEVPSITTDTMFVGRDWLFHEIDAQLQSEDDAVNRGVVICGNIGFGKTAIISRLVA 462

  Fly   906 YSCFGRRQMQ-------------------DDPDGIYSQLQLGAHC-----------ERMRGLASH 940
            .||.|.|..|                   ..|...:|.:..|: |           |.||.:|:.
Frog   463 LSCHGTRMRQINSDSPHASPKHSEANRELSQPGQTHSGITSGS-CPGTPEMRRRQEEAMRRIAAQ 526

  Fly   941 MVGYHFCQADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSEPHLQDILSVRECIADAERVMK 1005
            :|.||:||||...||.||:|||::||.||:||.|.|||:.||.|||||.:||:|.|:.|.....:
Frog   527 VVAYHYCQADNAYTCLVPEFVHNVAALLCRAPHLVAYREQLLREPHLQSLLSLRSCVQDPAASFR 591

  Fly  1006 LAILEPLAHLHRAGKIPAKVAVIVVDALCEAEYHRPDHGHTIASFLAQLTPHFPAWLKLVATVRT 1070
            ..:||||.:|::..|||.:..:|::|.|.|||:|:||:|.||.|||.::...||.||||:.||||
Frog   592 RGVLEPLENLYKERKIPDEDYIILIDGLNEAEFHKPDYGDTIVSFLNKMIGKFPRWLKLIVTVRT 656

  Fly  1071 QMLELVKAPSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIRMNIGGGGGQNSQSGSQPQT-- 1133
            .:.|:.|...:.:::||....::|:.||:..||..|:..|.||:.||       |.:|....|
Frog   657 TLQEITKQLPFHRISLDRLEENEAIDQDLQAYILQRIHSSSEIQNNI-------SLNGKMDNTTF 714

  Fly  1134 -KFVSHLQSLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSLAQIFLLHFNLRFPTARSFEQA 1197
             |..|||::||:||.||.||..|||.:|.||:|||||||:||||::::||..|:||||..|||:|
Frog   715 GKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMRFPTQSSFERA 779

  Fly  1198 APILNICLAALYPLTLDEIYYSMEALS-HGREALSWPDFMQRFKLLDGFLIKRLDNTYMFFHSSL 1261
            .|:||:.:|:|:|||.:.|:.::.|.| .|  .|.|.||.||.:.|..|||||.|.|.||.|.|.
Frog   780 LPLLNVAVASLHPLTDEHIFQAINAGSVDG--GLEWEDFQQRMENLSMFLIKRRDLTRMFVHPSF 842

  Fly  1262 REWLMRRDEGESNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLELGHHMLKAHLYGGTSLTL-LS 1325
            ||||:.|::||..|||||.|.||..:||..||.:..|:.|.|:|||||:||||::.|.|..: ::
Frog   843 REWLIWREDGEKTKFLCDPRSGHILLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVA 907

  Fly  1326 PRDLQSYWLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASPNHRTDYMGGAPILCIAAHEGI 1390
            ...||:.|::.:.|.:|.:|.:|||:|:||:|||||::.|||:.|:||:.:..|||||:.||.|.
Frog   908 SSILQALWISYSTDGLSMALASLRNLYTPNIKVSRLLITAGANVNYRTEVLNNAPILCVQAHLGY 972

  Fly  1391 LPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMG 1455
            ..||:|||||..:|..::..|.|||..||..||..:|..|....:.:..||...:|||||||..|
Frog   973 TEMVALLLEFYVNVDASSESGLTPLSYAAASGHLTIVMLLCKRRAKVDLLDKNGQCALVHAALRG 1037

  Fly  1456 HLSVVKYLLACDWSPRPHSQDV-TRSVALQQALIGAAAQAHCKILEDLLDL----NETEFDLDVN 1515
            ||.|||||:.|||:.......: .:|.|:|||||.||:..:.:|:..||||    .|.|....:|
Frog  1038 HLEVVKYLIQCDWTMAGQQPGILKKSQAIQQALIAAASMGYSEIVSYLLDLPEKDEEEEERAQIN 1102

  Fly  1516 GMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGAL 1580
            ..:...||.||||||..|.:||..:||.:||.:...||:|...::.||::|||.:|:.||..||.
Frog  1103 SFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVSQPNRRGVVPIFSAVRQGHWQIVDLLLTHGAD 1167

  Fly  1581 LDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHG 1645
            ::....|.| ||||.||.|||:..|:.|||:||.....|.||.|:||||||:|||:..:||:|.|
Frog  1168 VNMADKQGR-TPLMTAASEGHVATVEFLLAQGASISLMDKEGLTSLSWACLKGHLSVVRTLVESG 1231

  Fly  1646 CNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRK 1710
            ....|.|.||||.|||||:.|.|.:|.::::||..:||:|..||||||||:.|||...|...|:|
Frog  1232 AATDHADKNGRTPLDLAAFYGDAEVVQFLVDQGAMIEHVDYSGMRPLDRAVGCRNTSVVVALLKK 1296

  Fly  1711 GAKL----------GPTTWSMAMGKPEILVILLNKLLEDGNVLYRKNRFQEAAHRYQYALRKI-- 1763
            |||:          ||.||:||..||:|:||||:||:|:|::.|:|.:.:|||.||||||:|.
Frog  1297 GAKIGCQTLPSRPKGPATWAMATSKPDIMVILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPR 1361

  Fly  1764 SGLEQLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMEL 1828
            .|..:.|:   .|.:|:.:||||||||:||:|:...:.:.||:|:..||.|||.:||||:|:...
Frog  1362 EGFGEDLK---TFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAFYARARAKRSS 1423

  Fly  1829 GALNEALVDANEAMQQAAQSGVLC----EVVEVLKRIQTE 1864
            .....||.|.|||:|       ||    |:..:|.|::.|
Frog  1424 RQFTAALEDLNEAIQ-------LCPNNREIQRLLMRVEEE 1456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rols	NP_729778.1	zf-RING_5	327..364	CDD:291308
		Ank_5	1363..1418	CDD:290568	26/54 (48%)
		ANK	1378..1503	CDD:238125	56/125 (45%)
		ANK repeat	1382..1408	CDD:293786	13/25 (52%)
		ANK repeat	1410..1441	CDD:293786	10/30 (33%)
		Ank_2	1415..1552	CDD:289560	59/141 (42%)
		ANK	1486..1609	CDD:238125	53/126 (42%)
		ANK repeat	1486..1518	CDD:293786	13/35 (37%)
		ANK repeat	1521..1552	CDD:293786	15/30 (50%)
		Ank_2	1526..1619	CDD:289560	42/92 (46%)
		ANK	1549..1675	CDD:238125	61/125 (49%)
		ANK repeat	1554..1586	CDD:293786	11/31 (35%)
		ANK repeat	1591..1619	CDD:293786	15/27 (56%)
		Ank_2	1593..1685	CDD:289560	48/91 (53%)
		ANK repeat	1621..1652	CDD:293786	17/30 (57%)
		ANK repeat	1654..1685	CDD:293786	16/30 (53%)
		Ank_2	1659..1735	CDD:289560	43/85 (51%)
		ANK repeat	1687..1712	CDD:293786	14/24 (58%)
		TPR_11	1736..1812	CDD:290150	33/77 (43%)
		TPR repeat	1736..1768	CDD:276809	16/33 (48%)
		TPR repeat	1773..1810	CDD:276809	16/36 (44%)
		TPR_11	1783..1843	CDD:290150	30/59 (51%)
		TPR repeat	1815..1843	CDD:276809	13/27 (48%)
tanc2	XP_031750132.1	PHA03095	931..>1226	CDD:222980	137/295 (46%)
		ANK repeat	964..990	CDD:293786	13/25 (52%)
		ANK repeat	992..1023	CDD:293786	10/30 (33%)
		ANK repeat	1109..1139	CDD:293786	15/29 (52%)
		PHA02875	1110..>1331	CDD:165206	110/221 (50%)
		ANK repeat	1141..1172	CDD:293786	11/30 (37%)
		ANK repeat	1175..1205	CDD:293786	16/30 (53%)
		ANK repeat	1207..1238	CDD:293786	17/30 (57%)
		ANK repeat	1240..1271	CDD:293786	16/30 (53%)
		ANK repeat	1273..1303	CDD:293786	17/29 (59%)
		TPR	<1328..1456	CDD:223533	58/137 (42%)
		TPR repeat	1332..1357	CDD:276809	13/24 (54%)
		TPR repeat	1362..1405	CDD:276809	18/45 (40%)
		TPR repeat	1410..1438	CDD:276809	13/27 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	862	1.000	Inparanoid score	I421
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073736at2759
OrthoFinder	1	1.000	-	-		FOG0003165
OrthoInspector	1	1.000	-	-		otm49063
Panther	1	1.100	-	-	O	PTHR24166
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5649
SonicParanoid	1	1.000	-	-		X1834
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.190