DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rols and tanc1b

DIOPT Version :9

Sequence 1:	NP_729778.1	Gene:	rols / 39368	FlyBaseID:	FBgn0041096	Length:	1900	Species:	Drosophila melanogaster
Sequence 2:	XP_009303259.1	Gene:	tanc1b / 100334650	ZFINID:	ZDB-GENE-130530-956	Length:	1728	Species:	Danio rerio

Alignment Length:	1505	Identity:	557/1505 - (37%)
Similarity:	789/1505 - (52%)	Gaps:	252/1505 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 GGGHRRTA------------SNGGCPIDTASILSGDHTHQHHHRDNQPEGKE------SNALNTS 600
            ||.:::.|            :.||.|                  |..|...|      |..::.|
Zfish    12 GGKNKKDAGEPLVLSGQWRCAGGGMP------------------DPYPSADEGLRLGFSKGVSMS 58

  Fly   601 TCSDSAVTRRRRKNVSNHNLKTSARHGASSENRLNRLSLAGTSVYAGHLSSLVFGKIKSLWSVNS 665
            ..|...:.|        |....:||....|...:.:.....:....|.:.:....|:....:..|
Zfish    59 LPSSPLLPR--------HTYVMAARPCKKSPGLVRKPKYVESPRIPGDVCAASLKKVPDSATAGS 115

  Fly   666 SNSSEAGLNQLAGSDAIDHHSSFLNEKLQKDQLHARLGLLLND--PGS--------NGNSSSSGS 720
            |:|::                          :|..|||.||.:  |||        |........
Zfish   116 SSSTQ--------------------------ELMTRLGFLLGEGIPGSTHIPMDGKNDKKCPVNQ 154

  Fly   721 GCEPISAHSTTSTTSSSGVGAASTTTSGSSQN-------VSPEQTLAS-GAGML----------- 766
            |..|.|  :.||:|:|....:..:|.:.|.:.       .||..||.| .:|::
Zfish   155 GISPCS--TLTSSTASPSTDSPCSTLNSSGRPGLTAVCITSPSSTLDSKDSGIIATITSSSENEE 217

  Fly   767 -SGSQLSVATSHGVKEDALSLCGKFKAG--------CSMLHVYEALPSKSRKG-----NVRRSTR 817
             |||.|..:     ||.::..||:...|        ||  .|.|..||.|..|     |.::::.
Zfish   218 RSGSSLEWS-----KEGSIRSCGQHVLGQTATRTDTCS--PVAEEEPSASGTGLRIVPNTKKNSE 275

  Fly   818 G------QQGSS------SSASAASA---------------------------VGSRVTASSLA- 842
            |      |..||      :|.:|.|:                           .|.|.......
Zfish   276 GPVQYTTQNPSSLMMPRPNSVAATSSTKLEDLSFLDEQRNTPLRTSIRLPWHNTGGRAPHDKACF 340

  Fly   843 ----AVQLALKPLFFEVPLQEPDPPYVGRQWLVQQLSNILL------GTETRVVLINGQPGTGKT 897
                ...:.||||.||||....|..:|||.||.|||.:.|.      .:.:..:|: |..|.|||
Zfish   341 APYKPTDIMLKPLLFEVPSITTDSVFVGRDWLFQQLEDDLSPSQSGESSSSGSILV-GNVGFGKT 404

  Fly   898 AFCLQLVEYSCFGRR----------------QMQDD--------PDGIYSQL---------QLGA 929
            |...:||..||.|.|                :|..|        |....|.|         :|..
Zfish   405 AIISRLVALSCHGGRMRQIASNSPTASPKSAEMSSDVPLSQSTPPLSTSSTLSSSSCPNTPELQR 469

  Fly   930 HCER-MRGLASHMVGYHFCQADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSEPHLQDILSV 993
            |.:: :|.||:.:|.||:||||...||.||:||||::|.||:|.|||||||.||.|.|||.:||:
Zfish   470 HRDQAVRRLAAKVVAYHYCQADNTYTCLVPEFVHSVSALLCRAHQLTAYRDLLLKETHLQSVLSL 534

  Fly   994 RECIADAERVMKLAILEPLAHLHRAGKIPAKVAVIVVDALCEAEYHRPDHGHTIASFLAQLTPHF 1058
            |.|:.|.....:..||:||.:|.:..|||.:..:|:||.|.|||:|:||:|.|:|||:.::.|.|
Zfish   535 RSCVQDPSAAFRRGILQPLINLRKERKIPEEDCIILVDGLNEAEFHKPDYGDTVASFITKIIPKF 599

  Fly  1059 PAWLKLVATVRTQMLELVKAPSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIRMNIGGGGGQ 1123
            |:||||:.||||.:||:.....:::::||.:..:|.:..|:..||..|::.|..|..||    ..
Zfish   600 PSWLKLIVTVRTNLLEITSLMPFSKISLDDFPDNQEIGTDLNAYIQQRISGSQNILSNI----SL 660

  Fly  1124 NSQSGSQPQTKFVSHLQSLSRGSMLYAKLILDLIARGQLVIKSSSYKVLPVSLAQIFLLHFNLRF 1188
            |.:|.....:|..|||.|.|:||.||.||.|||..||.|||||:||||:||||::::||..|::|
Zfish   661 NGKSDPVIVSKVSSHLISRSQGSYLYLKLTLDLFERGHLVIKSASYKVVPVSLSELYLLQCNMKF 725

  Fly  1189 PTARSFEQAAPILNICLAALYPLTLDEIYYSMEALSHGREALSWPDFMQRFKLLDGFLIKRLDNT 1253
            .:..:||:|.||||:.||:|:|||.::::.::.|.|. |..|.|.||.||.:.|..|||:|.|.|
Zfish   726 LSNSAFERAVPILNVALASLHPLTDEQLFQALNAGSQ-RGELEWDDFQQRMETLSCFLIRRRDKT 789

  Fly  1254 YMFFHSSLREWLMRRDEGESNKFLCDARLGHAGIAFRLSRLQAPLSPQLTLELGHHMLKAHLYGG 1318
            .||.|.|.||||:.|.:|||:.||||.|.|||.:||.|||.:..|:.|.|:|||||:||||::.|
Zfish   790 RMFCHPSFREWLVWRADGESSDFLCDPRSGHALMAFMLSRQEGKLNRQQTMELGHHILKAHIFKG 854

  Fly  1319 TSLTL-LSPRDLQSYWLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASPNHRTDYMGGAPIL 1382
            .|..: :|...||:.|::.:.|.:|::|.:|||:|:||:|||||::|.||:.|:||:.:...|:|
Zfish   855 LSKKIGVSSSVLQALWISCSTDGLSAALASLRNLYTPNVKVSRLLMLGGANVNYRTEVLNNGPVL 919

  Fly  1383 CIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCA 1447
            |:.:|.|...||:|||||||:|.:.:..|.:.|..||..||.:::..|...|:.:..:|.:.:||
Zfish   920 CVQSHLGHQEMVALLLEFGANVDVLSENGMSALCYAAAAGHLELISLLCKRGAKVDHVDKSGQCA 984

  Fly  1448 LVHAARMGHLSVVKYLLACDWSPRPHSQDVTRSVALQQALIGAAAQAHCKILEDLLDLNETEFDL 1512
            |||||..||..|::.||...||.....:...:|.|||||||.|.:..|..:||.||.:|: |..:
Zfish   985 LVHAALRGHSEVIECLLELHWSSESQQEHSLKSRALQQALIAACSMGHIHVLEGLLAMND-ELSV 1048

  Fly  1513 DVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQR 1577
            .::..:...||.||||||..|.::|...||.|.||:...||:|..||:.||::|||.:.:.|||.
Zfish  1049 QIDAHDTLWGETALTAAAGRGKMEVCSFLLKREAQVQQVNRRGACALFCAVRQGHWQIADLLLQH 1113

  Fly  1578 GALLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLI 1642
            ||.::....|.| |.||:||.||||...|.||::||...:.|.||.|.||||||:||.:..:.|:
Zfish  1114 GADVNVSDKQGR-TLLMVAACEGHLSTADFLLSKGASVASVDKEGLTPLSWACLKGHKSVVQFLV 1177

  Fly  1643 EHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVF 1707
            |.|....|.|.|||:.|||||:.|.|.:|.|::|:|..:||:|..|||||||||.|||...|...
Zfish  1178 EKGAVIDHSDKNGRSPLDLAAFYGDADIVHYLVEKGAVIEHVDYSGMRPLDRAIGCRNTSVVLTL 1242

  Fly  1708 LRKGAKLGPTT----------WSMAMGKPEILVILLNKLLEDGNVLYRKNRFQEAAHRYQYALRK 1762
            |:||||||..|          |:||..||:||:|||.||:|:||:||::.:.:|||.||||||||
Zfish  1243 LKKGAKLGYRTSPYDRTGNAAWAMATSKPDILIILLQKLMEEGNLLYKRGKMKEAAQRYQYALRK 1307

  Fly  1763 I--SGLEQLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKAR 1825
            .  .|....|:   .|.:||.:|.||||||:||.|:...:.|.||:|:..||.|||.|||||:|:
Zfish  1308 FPREGFGDELK---AFKELRVSLYLNLSRCRRKTNDFGLAEDFATKALELKPKSYEAYYARARAK 1369

  Fly  1826 MELGALNEALVDANEAMQQAAQSGVLC----EVVEVLKRIQTELLTRISISSEDQTGRMSNIGGG 1886
            ........||.|.:||.:       ||    |:..:|.|::.|........|:.|  .:||
Zfish  1370 RSSRQFTAALADLHEASK-------LCPNNREICRLLARVEDECKQMQRSQSKQQ--NLSN---- 1421

  Fly  1887 ASVAYESHHE 1896
                 ..||:
Zfish  1422 -----PEHHQ 1426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rols	NP_729778.1	zf-RING_5	327..364	CDD:291308
		Ank_5	1363..1418	CDD:290568	23/54 (43%)
		ANK	1378..1503	CDD:238125	50/124 (40%)
		ANK repeat	1382..1408	CDD:293786	14/25 (56%)
		ANK repeat	1410..1441	CDD:293786	8/30 (27%)
		Ank_2	1415..1552	CDD:289560	53/136 (39%)
		ANK	1486..1609	CDD:238125	53/122 (43%)
		ANK repeat	1486..1518	CDD:293786	11/31 (35%)
		ANK repeat	1521..1552	CDD:293786	15/30 (50%)
		Ank_2	1526..1619	CDD:289560	43/92 (47%)
		ANK	1549..1675	CDD:238125	60/125 (48%)
		ANK repeat	1554..1586	CDD:293786	13/31 (42%)
		ANK repeat	1591..1619	CDD:293786	14/27 (52%)
		Ank_2	1593..1685	CDD:289560	46/91 (51%)
		ANK repeat	1621..1652	CDD:293786	15/30 (50%)
		ANK repeat	1654..1685	CDD:293786	16/30 (53%)
		Ank_2	1659..1735	CDD:289560	45/85 (53%)
		ANK repeat	1687..1712	CDD:293786	15/24 (63%)
		TPR_11	1736..1812	CDD:290150	36/77 (47%)
		TPR repeat	1736..1768	CDD:276809	18/33 (55%)
		TPR repeat	1773..1810	CDD:276809	17/36 (47%)
		TPR_11	1783..1843	CDD:290150	30/59 (51%)
		TPR repeat	1815..1843	CDD:276809	13/27 (48%)
tanc1b	XP_009303259.1	ANK	892..1001	CDD:238125	46/108 (43%)
		ANK repeat	919..945	CDD:293786	14/25 (56%)
		ANK repeat	947..978	CDD:293786	8/30 (27%)
		Ank_2	1024..1121	CDD:315466	40/97 (41%)
		ANK repeat	1058..1088	CDD:293786	15/29 (52%)
		ANK	1086..1210	CDD:238125	60/124 (48%)
		ANK repeat	1090..1121	CDD:293786	13/30 (43%)
		ANK repeat	1124..1154	CDD:293786	15/30 (50%)
		ANK	1152..1278	CDD:238125	63/125 (50%)
		ANK repeat	1156..1187	CDD:293786	15/30 (50%)
		ANK repeat	1189..1220	CDD:293786	16/30 (53%)
		TPR	<1221..1409	CDD:223533	90/197 (46%)
		ANK repeat	1222..1252	CDD:293786	20/29 (69%)
		TPR repeat	1281..1306	CDD:276809	14/24 (58%)
		TPR repeat	1324..1354	CDD:276809	15/29 (52%)
		TPR repeat	1359..1385	CDD:276809	11/25 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BH8T
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	858	1.000	Inparanoid score	I412
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073736at2759
OrthoFinder	1	1.000	-	-		FOG0003165
OrthoInspector	1	1.000	-	-		otm24771
orthoMCL	1	0.900	-	-		OOG6_105209
Panther	1	1.100	-	-	LDO	PTHR24166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1834
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830