DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6928 and Slc26a11

DIOPT Version :9

Sequence 1:	NP_648539.1	Gene:	CG6928 / 39367	FlyBaseID:	FBgn0036240	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_038943458.1	Gene:	Slc26a11 / 360670	RGDID:	1306178	Length:	593	Species:	Rattus norvegicus

Alignment Length:	610	Identity:	228/610 - (37%)
Similarity:	343/610 - (56%)	Gaps:	51/610 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RLLPGLKWLHGYTGQDAVADLIAGVTVGLTVLPQGLAYATLAGLEPQYGLYSAFVGGIIYAMLGS 73
            |.||.|.||..|:.:....|:|||::|||||:||.||||.:|||.|||||||||:|..:|.:||:
  Rat    15 RRLPVLAWLPNYSLRWLRMDVIAGLSVGLTVIPQALAYAEVAGLPPQYGLYSAFMGCFVYFVLGT 79

  Fly    74 CRQVTIGPTALLALMTSRHTGFGLGSGPAYAILLCLISGVVELGMAVLKLGALVDLISLPVTVGF 138
            .|.||:||||:::|:.|.:|    ...||||:||..:||.::|.|.:|.||.|:|.||.||..||
  Rat    80 SRDVTLGPTAIMSLLVSYYT----FREPAYAVLLAFLSGCIQLAMGLLHLGFLLDFISCPVIKGF 140

  Fly   139 TSATAVIIGTSQLKGLLGLRGGSGSDFINTMRSVFGNLHKVRTGDFTLGLTSIIVLLLLRKLKD- 202
            |||.::.||..|:|.||||:......|:....: |.::.:.|.||..|||..:::||:|:.:::
  Rat   141 TSAASITIGFGQVKNLLGLQNIPRQFFLQVYHT-FLHIGETRVGDAILGLVCMVLLLVLKLMREH 204

  Fly   203 -----------VKLDGRIRNLRTQQLVSGSIWVIGTGRNALVVLVTSVLAYSTCEQMESCPFILT 256
                       ||..            .|.:|.:.|.||||||...:::||: .|...|.|||||
  Rat   205 IPPPHPEMPLGVKFS------------RGLVWTVTTARNALVVSFAALIAYA-FEVTGSHPFILT 256

  Fly   257 GKVKSGLPNVSLPKFETTILDRNGTEIRQNFEQMLSELGPSMLILPIIAVLGNVAISKAFGGAG- 320
            ||:..|||.|.:|.|..|..::.     .:|.:|:.::|..:.::|::.:|..:|::|:|....
  Rat   257 GKIAQGLPPVRMPPFSVTTDNKT-----ISFSEMVQDMGVGLAVVPLMGLLETIAVAKSFASQNN 316

  Fly   321 --LSPTRELVALSMSNICGAFCSSMPVTGSFSRSAVNHASGVRTPLGGCYTSVLVLLALGLLAPY 383
              :...:||:|:.::|:.|:..||.||||||.|:|||..:||.||.||..|.|||||:|..|...
  Rat   317 YRIDANQELLAIGLTNVLGSLVSSYPVTGSFGRTAVNAQTGVCTPAGGLVTGVLVLLSLDYLTLL 381

  Fly   384 FQYIPKAALSAVIISAVIFMIEFEVIKPLWRCSRRELLPGAITFVMSLAVGVEIGLLLGVSTDVA 448
            |.||||:||:||||.||..:.:.::.:.||...|.:|||..:||::|. ..::.|:|.|....:.
  Rat   382 FYYIPKSALAAVIIMAVAPLFDVKIFRRLWLVQRLDLLPLCVTFLLSF-WEIQYGILAGTLVSLL 445

  Fly   449 FLVYRAARPVLSVSKLQTTNGINYILIRPKHSSLYFPAVEWVRSGISK-ALTIHGTAPVVLDCAH 512
            .|::..|||...||:.|       ||:....|.|:||||:.:|..::| ||........||:|.|
  Rat   446 ILLHSVARPKTQVSEGQ-------ILVLQPASGLHFPAVDALREAMTKRALEASPPRSAVLECTH 503

  Fly   513 VHEFDFTAARGMGSLQKELAKANAPLFLMSADKTIGVILKESTNIDFPTIDCPDDLEFLLEQ--- 574
            |...|:|...|:|.|.::..|....|..:.....:...|..:....|......::.|..|:|
  Rat   504 VSNIDYTVILGLGELLEDFQKKGVTLAFVGLQVPVLRTLLAADLKGFQYFTTLEEAEKSLQQEPG 568

  Fly   575 TADYVLHLQISAPLVESRLVHGDSG 599
            |..|.:. :.:||...|.|:...||
  Rat   569 TQPYSIR-EDTAPEHRSSLLKSPSG 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6928	NP_648539.1	sulP	12..531	CDD:273284	211/534 (40%)
CG6928	NP_648539.1	STAS_SulP_like_sulfate_transporter	471..>540	CDD:132913	24/69 (35%)
Slc26a11	XP_038943458.1	sulP	18..542	CDD:273284	213/554 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335191
Domainoid	1	1.000	44	1.000	Domainoid score	I12025
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55446
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.860