DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6928 and SLC26A11

DIOPT Version :9

Sequence 1:	NP_648539.1	Gene:	CG6928 / 39367	FlyBaseID:	FBgn0036240	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_016879994.1	Gene:	SLC26A11 / 284129	HGNCID:	14471	Length:	696	Species:	Homo sapiens

Alignment Length:	581	Identity:	227/581 - (39%)
Similarity:	325/581 - (55%)	Gaps:	70/581 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RLLPGLKWLHGYTGQDAVADLIAGVTVGLTVLPQGLAYATLAGLEPQYGLYSAFVGGIIYAMLGS 73
            |.||.|.||..|:.|....|.:||::||||.:||.||||.:|||.|||||||||:|..:|..||:
Human    98 RRLPILAWLPSYSLQWLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGT 162

  Fly    74 CRQVTIGPTALLALMTSRHTGFGLGSGPAYAILLCLISGVVELGMAVLKL--------------- 123
            .|.||:||||:::|:.|.:|    ...||||:||..:||.::|.|.||:|
Human   163 SRDVTLGPTAIMSLLVSFYT----FHEPAYAVLLAFLSGCIQLAMGVLRLAHISPHPLGLGGAGT 223

  Fly   124 ---------GALVDLISLPVTVGFTSATAVIIGTSQLKGLLGLRGGSGSDFINTMRSVFGNLHKV 179
                     |.|:|.||.||..|||||.||.||..|:|.||||:......|:....: |..:.:.
Human   224 SSMSPLGWPGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRPFFLQVYHT-FLRIAET 287

  Fly   180 RTGDFTLGLTSIIVLLLLRKLKD------VKLDGRIRNLRTQQLVSGSIWVIGTGRNALVVLVTS 238
            |.||..|||..:::||:|:.::|      .::...:|      |..|.:|...|.||||||...:
Human   288 RVGDAVLGLVCMLLLLVLKLMRDHVPPVHPEMPPGVR------LSRGLVWAATTARNALVVSFAA 346

  Fly   239 VLAYSTCEQMESCPFILTGKVKSGLPNVSLPKFETTILDRNGTEIRQNFEQMLSELGPSMLILPI 303
            ::||| .|.....||||||:...|||.|.:|.|..|  ..|||   .:|.:|:.::|..:.::|:
Human   347 LVAYS-FEVTGYQPFILTGETAEGLPPVRIPPFSVT--TANGT---ISFTEMVQDMGAGLAVVPL 405

  Fly   304 IAVLGNVAISKAFGGAG---LSPTRELVALSMSNICGAFCSSMPVTGSFSRSAVNHASGVRTPLG 365
            :.:|.::|::|||....   :...:||:|:.::|:.|:..||.||||||.|:|||..|||.||.|
Human   406 MGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAG 470

  Fly   366 GCYTSVLVLLALGLLAPYFQYIPKAALSAVIISAVIFMIEFEVIKPLWRCSRRELLPGAITFVMS 430
            |..|.|||||:|..|...|.||||:||:||||.||..:.:.::.:.|||..|.:|||..:||::.
Human   471 GLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLFDTKIFRTLWRVKRLDLLPLCVTFLLC 535

  Fly   431 LAVGVEIGLLLGVSTDVAFLVYRAARPVLSVSKLQTTNGINYILIRPKHSSLYFPAVEWVRSGI- 494
            . ..|:.|:|.|....:..|::.||||...||:       ..:|:....|.|.|||:|.:|..|
Human   536 F-WEVQYGILAGALVSLLMLLHSAARPETKVSE-------GPVLVLQPASGLSFPAMEALREEIL 592

  Fly   495 SKALTIHGTAPVVLDCAHVHEFDFTAARGMGSLQKELAKANAPL-----------FLMSAD 544
            |:||.:.....:||:|.||...|:|...|:|.|.::..|....|           .|:|||
Human   593 SRALEVSPPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFVGLQVPVLRVLLSAD 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6928	NP_648539.1	sulP	12..531	CDD:273284	219/552 (40%)
CG6928	NP_648539.1	STAS_SulP_like_sulfate_transporter	471..>540	CDD:132913	24/80 (30%)
SLC26A11	XP_016879994.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141500
Domainoid	1	1.000	43	1.000	Domainoid score	I12371
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2728
OMA	1	1.010	-	-		QHG55446
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.670