DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pop2 and CNOT7

DIOPT Version :9

Sequence 1:	NP_001287041.1	Gene:	Pop2 / 39366	FlyBaseID:	FBgn0036239	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001309022.1	Gene:	CNOT7 / 29883	HGNCID:	14101	Length:	307	Species:	Homo sapiens

Alignment Length:	339	Identity:	190/339 - (56%)
Similarity:	231/339 - (68%)	Gaps:	65/339 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PHAHIPSNEECGIRDVWKQNLEEEFRTIRKVVQKYHYVAMDTEFPGVVARPVGEFRSTADYHYQL 77
            |.|.:..::.  |.:||..||:||.:.||:|::||:|||||||||||||||:|||||.|||.|||
Human     2 PAATVDHSQR--ICEVWACNLDEEMKKIRQVIRKYNYVAMDTEFPGVVARPIGEFRSNADYQYQL 64

  Fly    78 LRCNVDLLRIIQLGLTFMDDDGKTPPGYSTWQFNFKFNLS----------------------EDM 120
            ||||||||:|||||||||::.|:.|||.|||||||||||:                      |||
Human    65 LRCNVDLLKIIQLGLTFMNEQGEYPPGTSTWQFNFKFNLTLGVVAHACNPSTLGGRGGRITREDM 129

  Fly   121 YAQDSIDLLQNSGIQFKKHEEDGIDPIDFAELLMSSGIVLVENIKWLCFHSGYDFGYLLKLLTDQ 185
            ||||||:||..||||||||||:||:...||||||:||:||.|.:|||.||||||||||:|:||:.
Human   130 YAQDSIELLTTSGIQFKKHEEEGIETQYFAELLMTSGVVLCEGVKWLSFHSGYDFGYLIKILTNS 194

  Fly   186 NLPPDESEFFDLLHIYFPNIFDIKYLMKSCKNLKGGLQEVADQLELRRVGPQHQAGSDALLTGMA 250
            |||.:|.:||::|.::||.|:|:||||||||||||||||||:||||.|:|||||||||:||||||
Human   195 NLPEEELDFFEILRLFFPVIYDVKYLMKSCKNLKGGLQEVAEQLELERIGPQHQAGSDSLLTGMA 259

  Fly   251 FFKMREVQHTNDFHITPVAHDVLFRYLLEHTMNLKPTISCIHLLSRPAYNGGPAPDESAIISSG- 314
            ||||||:                  :..:|..:.|   .|.||..               :.||
Human   260 FFKMREM------------------FFEDHIDDAK---YCGHLYG---------------LGSGS 288

  Fly   315 ----NGTGNTNSTE 324
                |||||....|
Human   289 SYVQNGTGNAYEEE 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pop2	NP_001287041.1	CAF1	25..257	CDD:304961	174/253 (69%)
CNOT7	NP_001309022.1	CAF1	1..301	CDD:304961	189/336 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159563
Domainoid	1	1.000	195	1.000	Domainoid score	I3148
eggNOG	1	0.900	-	-		E1_COG5228
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49011
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2095
Isobase	1	0.950	-	0	Normalized mean entropy	S870
OMA	1	1.010	-	-		QHG54002
OrthoDB	1	1.010	-	-		D365788at33208
OrthoFinder	1	1.000	-	-		FOG0001271
OrthoInspector	1	1.000	-	-		otm40815
orthoMCL	1	0.900	-	-		OOG6_101138
Panther	1	1.100	-	-	LDO	PTHR10797
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R161
SonicParanoid	1	1.000	-	-		X785
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750