Protein Alignment Grip163 and SPC97

DIOPT Version :10

• Sequence 1: NP_648537.2
• Gene: Grip163 / 39365
• FlyBaseID: FBgn0026432
• Length: 1351
• Species: Drosophila melanogaster
• Sequence 2: NP_012042.1
• Gene: SPC97 / 856577
• SGDID: S000001215
• Length: 823
• Species: Saccharomyces cerevisiae
• Alignment Length: 977
• Identity: 179/977 - (18%)
• Similarity: 334/977 - (34%)
• Gaps: 298/977 - (30%)

  Fly   448 ELDESVNEI-FISRCLNTSPSF-TNQCSKEF-FDKSYQVDNEAIPEFLVGCEEEILQC-----GK 504
            ||....|.| .:.:.:|..|.: ||...|.| .:|....|...:.|.||  .:::|..     |.
Yeast    11 ELLRYTNNIPLLGKLVNHQPLWSTNPKLKSFSLEKISAPDQRRVQEALV--VKDLLNVLIGLEGT 73

  Fly   505 YNLVLRAYNAQHPVFDVQYPDIVVCLTEQQLKNMRRNL---ADKYAII---YKR-----FGWCSM 558
            |......|....|...:::.  :....:...|...|.:   ..:|.|:   |::     ||....
Yeast    74 YIRYFNDYEPSDPETPIEFK--IAKKMDPSFKTFSRRIVRYGKQYMILTRAYEKWSDTSFGMVLQ 136

  Fly   559 QSIFEDRMATKRVFANLMVKRTQAHLDAWAQKQRELQIKANAQKKLQNDQLNAEQERIQQNHLEK 623
            :..:|.|...:.|:...:|:|.:...:                 |:.|..:             :
Yeast   137 RFAYEIRRFLEDVYLKTLVERLERDFN-----------------KVPNFSI-------------R 171

  Fly   624 RRQDIVNELAFQRECERMEDKLLEREKQELQKKVVQLAAVLSSSPDRSTVSDLSFASCIEEPDCL 688
            ..:.|:||....::.|     ||....:|:.:::          .:|.|
Yeast   172 ELEQIINETEVNKQME-----LLYNIYEEIFREI----------EERRT---------------- 205

  Fly   689 AESSSDKDDANT--ENSEDEATKQL------DKTLNVPLEQPEAEYQADVDVDQPRGKECSLPNV 745
              :.|.::|.|.  ::.::|::..|      |.|:                  .|..|..::..:
Yeast   206 --NQSSQEDFNNFMDSMKNESSLHLRLMVAFDTTV------------------YPVPKGGAILKI 250

  Fly   746 FQYQRSHSDVINSNEHPTTQAEFNRNRQHGLSSDQFQQCHATVHLQESDLLKTAASTSSGLHAEI 810
            ||.:      |..|....:...|.:...:.:|.|     :.|:                 |:..:
Yeast   251 FQQK------ILENLGDRSSVMFLKKLLNNISQD-----YCTM-----------------LYEWL 287

  Fly   811 PQDINANLNCPDTKELTELQRNRKRNEHHDGFFSFNSTEDEHTHRLRS---LLNSNTERGRNRL- 871
            .|.|   ||.|..:.:|......|.    |..|.......:..:.:|.   |.:.::|..:|.|
Yeast   288 TQGI---LNDPYQEFMTYDDLEGKT----DNIFDTRDRAWDTQYFIRKDVLLRDCDSEEDKNLLF 345

  Fly   872 RVMETEFGLGYKNTDIETKATPCLPLEIDKLHVEIPLAVLTPMSTTSDVDFGDPSPRELPEIADT 936
            :::.|.                 :.|::.:..::||    |..|.:||:..     :|:.:.||.
Yeast   346 KMLRTG-----------------ILLKVVRASLQIP----TIPSNSSDITI-----QEINDFADL 384

  Fly   937 ANNNNVSGSIESLSPELPKPVLAIAKPTSLLPKLDFGMKDERETEQDRDKVSTLPEACNPFM--- 998
            ...:|:...::.          ..::...:..||.|         |..|.::.|......|:
Yeast   385 MEGSNLELYVDK----------CYSRANEIFLKLFF---------QGYDLINVLKHLQQIFLGYQ 430

  Fly   999 -ARRCLQLSV--MAPLNAYYGLLRNE-------VLRIFQEQRIYEHFRKLRNYFFLVDGQFGATL 1053
             ....|:...  |..|..:|   ||:       :|:.|:.:|..|:...|.....::  ||....
Yeast   431 SGHNVLKFLTKNMGELTKHY---RNDNNANYDKLLQNFELERQSENPNNLMRQLLMI--QFDTET 490

  Fly  1054 TNEILG---RIRAGVGPRSLSQKGILDTIL-------TNALA--ACSADETTV--SENLTLNCTT 1104
            ..::|.   :|...| |.:.|.....|.::       .||:.  ..|.:.|..  ..||.|
Yeast   491 LPQVLSHYLQIYPEV-PENNSANDDSDPLMHANNFKNMNAILFDELSKERTGAYHGSNLEL---- 550

  Fly  1105 IPDTLNFLSVEATSMLKLNCKIDWPLNMVISSETISKYGQIFGYLLKLRHVSFVLDGTYEYLQQM 1169
                  :....|...||.:..|.:|||::||...:.||..|..|.|.|::.|.:||.|:   ..:
Yeast   551 ------YTPKSAIYHLKFDINIPYPLNIIISRTCMIKYQIILRYQLVLQYHSRLLDETW---MDL 606

  Fly  1170 GKLLGPELRTCTH------FRHMQMMRHKMSHF----MTSFQTHLVAKALLSTWKSFKEELCTAD 1224
            .|....:.|..:|      .|..:::..||:||    |..|..:::.|.:.|..|.::......
Yeast   607 NKTPSWKYRGYSHTVKRRIVRATRVLHAKMNHFIKTIMEYFNQNVIDKEVYSLEKCYRNPTLAV- 670

  Fly  1225 SIEALYKQHVAYLKRVAFLALLNRRSAKVKETIDNILVIILRFCKVIQSQSFIVDQDNYFVHPRF 1289
               |:..:....|..:    :.||..:.:......|..|:.:|||.|:|.             |.
Yeast   671 ---AIQNELEGGLTNI----MTNRCLSDLIPLQLQIFDIVYKFCKFIKSM-------------RA 715

  Fly  1290 KRLQQEEAEFEKFLQYLIYLGNKA--AASGYQEEIG-------DLI----------------CII 1329
            |..|.:...:||....::...|:.  ..:|.||::|       :||                |:|
Yeast   716 KLCQLDPVLYEKHKSGMMKTLNEGYRTNNGGQEDVGYQEDAALELIQKLIEYISNASSIFRKCLI 780

  Fly  1330 NF 1331
            ||
Yeast   781 NF 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip163	NP_648537.2	GCP_N_terminal	273..523	CDD:465456	20/82 (24%)
		EnvC	<532..>677	CDD:443969	23/155 (15%)
		GCP_C_terminal	1033..1335	CDD:461187	76/348 (22%)
SPC97	NP_012042.1	GCP_N_terminal	60..410	CDD:465456	74/503 (15%)
		GCP_C_terminal	<560..>653	CDD:461187	28/95 (29%)