Protein Alignment Grip163 and TUBGCP6

DIOPT Version :10

• Sequence 1: NP_648537.2
• Gene: Grip163 / 39365
• FlyBaseID: FBgn0026432
• Length: 1351
• Species: Drosophila melanogaster
• Sequence 2: NP_065194.3
• Gene: TUBGCP6 / 85378
• HGNCID: 18127
• Length: 1819
• Species: Homo sapiens
• Alignment Length: 1874
• Identity: 350/1874 - (18%)
• Similarity: 612/1874 - (32%)
• Gaps: 658/1874 - (35%)

  Fly    37 VAKKRSK----------IYESLLHSETMSSQDKLEMLHQVTSEVAKNPDRMDMLLRFQNLLEGQD 91
            |.:||:|          ::.:|...||          .|:..:::|.|.|..:|:...:|..|..
Human    28 VNRKRAKRSLKKVAYNALFTNLFQDET----------QQLQPDMSKLPARNKILMLSFDLRVGGL 82

  Fly    92 KEESEITQDQDEENQS-------------EVVIKRIKAGPLQLI--------------------- 122
            ..:::..::..||.::             :::::...:||.|::
Human    83 GPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGSGPPQVLPRKRDYFLNNKHVGRNVPYSG 147

  Fly   123 -----------------------------ETIEIVEEA--------------------------- 131
                                         ||::::|.|
Human   148 YDCDDLSVFEMDVQSLISREECLCHSMIQETLQVMEAAPGTGLPTVGLFSFGDPCGDRFERDTRV 212

  Fly   132 ------LHPKAFP-DINQMNRALKPLQLQPYSDILTTSNLNINFPP-------------EKLIP- 175
                  :|.:.:. |:.        |.|.|..|....|.|.|..||             ..|.|
Human   213 SLFGALVHSRTYDMDVR--------LGLPPVPDNADLSGLAIKVPPSVDQWEDEGFQSASNLTPD 269

  Fly   176 -KIIPSTVIRMGLSESI----TRMRNEMEKPMHPPPRLPVLAKKVVAPLEDERPFVAQPGPEKHF 235
             :..||....:.|.|:.    ...|...|:...||.             ..|.|::.:.|.:...
Human   270 SQSEPSVTPDVDLWEAALTYEASKRRCWERVGCPPG-------------HREEPYLTEAGRDAFD 321

  Fly   236 VSDKLLTNELKILRNKNL-----VLNYLDEATLIDHLKKAACGIESLTFPI---SSADKLELRVR 292
            ...:|...||::|....|     ||  :.|..|:..:.....|:.|.||.:   :.|..::..|.
Human   322 KFCRLHQGELQLLAGGVLQAPQPVL--VKECELVKDVLNVLIGVVSATFSLCQPAQAFVVKRGVH 384

  Fly   293 PNTTLPTMLPEVLADFANHFIRAGCAFLRLSSRTKWNNIAEMRLERPLNRAMRETIMDYLSTTRQ 357
            .:...|..:..:|::.|.:    |..:.|||..:....:..:..:..:.:|....:..||...|.
Human   385 VSGASPESISSLLSEVAEY----GTCYTRLSHFSLQPVLDSLYSKGLVFQAFTSGLRRYLQYYRA 445

  Fly   358 FLLS-------LQADSLFQLLNNTSTAIQLLCQLDRMFENE----PRLNLNTGITGSFLLSSIWL 411
            .:||       |....||:.|......:..||.:..:....    ||....||:.   |||.::.
Human   446 CVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVGAVLPGTCGGGPRAAFPTGVK---LLSYLYQ 507

  Fly   412 -AIDTCGNKDFLHLLIYFLRCISRNYFIQLQRWIYHGELDESVNEIFISRCLNTSPSFTNQCSKE 475
             |:..|.|:.: .:|:..|:.....|...:..|:|.|...::..|..|.         .|.....
Human   508 EALHNCSNEHY-PVLLSLLKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQ---------VNHEYLS 562

  Fly   476 FFDKSY----------QVDNEAIPEFLVGCEEEILQCGKYNLVLRAYNAQHPV--FDVQYPDIVV 528
            |.||.|          :|: :.:|.||.....:|..|||...:|:....:|.:  .||..|.|.|
Human   563 FRDKLYWTHGYVLISKEVE-DCVPVFLKHIAHDIYVCGKTINLLKLCCPRHYLCWSDVPVPRISV 626

  Fly   529 CLTEQQLKNMRRNLA---------DKYAIIYK-----RFGWCSMQSIFEDRMATKRVFANLMVKR 579
            ..:.::||.:.::.|         .:::.:.|     |......:.|...|.|..||.:.|..::
Human   627 IFSLEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQ 691

  Fly   580 TQAHLDAWAQKQRELQ------IK------ANAQKKLQND-----QLNAEQERIQ--QNHLE-KR 624
            ....:...|:|:.:.|      :|      |..|::|.:|     :|...:.|::  :..|| |.
Human   692 MSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKA 756

  Fly   625 RQDIVNELA-FQRECERMEDK-----------------LLEREK--QELQKKV------------ 657
            ||.:|:..: ...|..|.|.|                 |||.||  ||:.|.|
Human   757 RQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDV 821

  Fly   658 ----------------------------------------------------------------- 657
                                                                             
Human   822 LLSVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEG 886

  Fly   658 -------------------------------VQLA-----------------AVLSSSPDR---- 670
                                           :::|                 |..|:.|.|
Human   887 ARPFSDSLSIGDFLPVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEY 951

  Fly   671 --STVSDLSFASC-----IEEPDC--------LAESSSDKDDANTENSEDEATKQ-------LDK 713
              |||...:.|:.     ::..:|        |.|.|..|.||....|.:.....       |::
Human   952 DFSTVLRPAVATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEE 1016

  Fly   714 TLNVPLEQ----------PEAEYQADVDVDQPRGKECSLPNVFQYQRSHSDVI--------NSNE 760
            ..:.|.|:          |..:|.:::...:||            ..:|..|.        |.::
Human  1017 GSSQPTERLFGQVSGGGLPTGDYASEIAPTRPR------------WNTHGHVSDASIRVGENVSD 1069

  Fly   761 HPTTQAEFNRNRQHGLSSDQFQQCHATVHLQESDLLKTAASTSS--GLHAEIPQ-DINANLNCPD 822
            ...||..:|   .||..|      :|::.|.||  :...|.|..  .:|..:.. .|....|..|
Human  1070 VAPTQPRWN---THGHVS------NASISLGES--VSDVAPTRPRWNIHGHVSNASIRVGENVSD 1123

  Fly   823 T---------------------KELTELQRNRKR-NEH---HDGFFSF-NSTEDEHTHRLR---- 857
            .                     :.::::...|.| |.|   .|...|. .|..|....|.|
Human  1124 VAPTRPRWNTHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTH 1188

  Fly   858 --------SLLNSNTERGRNRLR------VMETEFGLGYKNTDIETKATPC--------LPLEID 900
                    ||..|.::....|.|      |.:|...:|...:|:....:.|        ..:.:.
Human  1189 GHVSDASISLGESVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLG 1253

  Fly   901 K-------------LHVEIP-----LAVLTP--------------------------MSTTSDVD 921
            :             .||.||     |..|:|                          .||.  :|
Human  1254 EPVSDVVSTRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTV--LD 1316

  Fly   922 FGDPSPREL-PEIADTAN---------NNNV--------------------------SGSIESLS 950
            .|...|.|: |.::..::         ..||                          ||..|.||
Human  1317 CGPRLPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDLS 1381

  Fly   951 PELP-------------------------------------------------------KPVLAI 960
            |..|                                                       .|:..:
Human  1382 PNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSEPPIAHL 1446

  Fly   961 AKPTSLLPK-LDFGMKDERETEQDRDKVSTLPEACNPFMARRCLQLSVMAPLNAYYGLLRNEVL- 1023
            .:|  :||: ..|.:..:.::..|...|........|.:.:|    |:.|||.|:..|:....:
Human  1447 LRP--VLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKR----SITAPLAAHISLVNKAAVD 1505

  Fly  1024 RIFQEQRIYEHFRKLRNYFFLVDGQFGATLTNEILGRIRAGVGPRSLSQKGILDTILTNALAACS 1088
            ..|.|..:..|:..||::..:.||:|..:|::.:..::.||..|..|....:|:::|:.||....
Human  1506 YFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNSVLSKALQCSL 1570

  Fly  1089 ADETTVSENLTLNCTTIPDTLNFLSVEATSMLKLNCKIDWPLNMVISSETISKYGQIFGYLLKLR 1153
            ..:|..:.||:|....:|:.....:.:..|.|:|..|:|||||:||:...:|||..:|.:||:|:
Human  1571 HGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGCVSKYSGVFSFLLQLK 1635

  Fly  1154 HVSFVLDGTYEYLQQMGKLLGPELRTCTHFRHMQMMRHKMSHFMTSFQTHLVAKALLSTWKSFKE 1218
            .:.:.|.....:|::...|  ..:.....||.:|:.:|:|.||:...|.::..:.|..||..|:.
Human  1636 LMMWALKDVCFHLKRTALL--SHMAGSVQFRQLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRA 1698

  Fly  1219 ELCTADSIEALYKQHVAYLKRVAFLALLNRRSAKVKETIDNILVIILRFCKVIQSQSF-IVDQDN 1282
            .|.|...:|.:.:.|..||.:..|..||..::|.|...|.:|..::|:|...:.||:: ......
Human  1699 RLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKFRSQLISQAWGPPGGPR 1763

  Fly  1283 YFVHPRFKRLQQEEAEFEKFLQYLIYLGNKAAASGYQEEIGDLICIINFNHYYK 1336
            ...||.|..:||....|:.:..:|..:..|....|||..:.|.:..||||:||:
Human  1764 GAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQPHLEDFLLRINFNNYYQ 1817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip163	NP_648537.2	GCP_N_terminal	273..523	CDD:465456	60/276 (22%)
		EnvC	<532..>677	CDD:443969	48/329 (15%)
		GCP_C_terminal	1033..1335	CDD:461187	86/302 (28%)
TUBGCP6	NP_065194.3	GCP6_N	28..342	CDD:466048	52/344 (15%)
		GCP_N_terminal	353..633	CDD:465456	63/297 (21%)
		DUF5401	<630..834	CDD:375164	40/203 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	810..889		0/78 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	929..951		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1000..1023		2/22 (9%)
		9 X 27 AA tandem repeats	1027..1269		43/264 (16%)
		DUF4573	1041..1208	CDD:434493	34/189 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1271..1412		21/142 (15%)
		GCP_C_terminal	1513..1816	CDD:461187	86/304 (28%)