Protein Alignment Grip163 and Tubgcp2

DIOPT Version :10

• Sequence 1: NP_648537.2
• Gene: Grip163 / 39365
• FlyBaseID: FBgn0026432
• Length: 1351
• Species: Drosophila melanogaster
• Sequence 2: NP_598516.2
• Gene: Tubgcp2 / 74237
• MGIID: 1921487
• Length: 905
• Species: Mus musculus
• Alignment Length: 1098
• Identity: 208/1098 - (18%)
• Similarity: 357/1098 - (32%)
• Gaps: 346/1098 - (31%)

  Fly    12 LDLVTKMATMLVADEMKPKKQTAVLVAKKRSKIYESLLHSETMSSQDKLEMLHQVTSEVAKNPDR 76
            :||:.|..|        |...|.|.....:.||.|.     :.:.:|.|:...::.|:..:|.|.
Mouse    29 IDLLQKNRT--------PYVTTTVSAHSAKVKIAEF-----SRTPEDFLKKYDELKSKNTRNLDP 80

  Fly    77 MDMLLRFQNLLEGQDKEESEITQDQDEENQSEVVIKRIKAGPLQLIETIEIVEEALHPKAFPDIN 141
            :..||             |::|:|:                     ||::.:::          |
Mouse    81 LVYLL-------------SKLTEDK---------------------ETLQFLQQ----------N 101

  Fly   142 QMNRALKPLQLQPYSDILTTSNLNINFPPEKL-----------IPKIIPSTVIRMGLSESITRMR 195
            ...||    :|...:....|::.:|.....|:           :..:...:.::..|..:...:|
Mouse   102 AKERA----ELAASAATSNTTSFSIPVAASKMSTQELEELRKQLGSVSTGSTLQQSLELTRKMLR 162

  Fly   196 NEMEKPMHPPPRLPVLAKKVVAPLEDERPFVAQPGPEKHFVSDKLLTNELK---ILRNKNLVLNY 257
            ::..|.....| |||....|.     |||.:|         .|.|:.:.|.   :|....|.| .
Mouse   163 DKQNKKNSGQP-LPVFPAWVY-----ERPTLA---------GDFLIGSGLSSDTVLPIGTLPL-A 211

  Fly   258 LDEATLIDHLKKAACGIES---LTFPISSADKLELRVRPNTTLPTMLPEVLADFANHFIRAGCAF 319
            ..|:.:::.|.....|::.   ...|::........|.||..|.      :.:..|..:....::
Mouse   212 SQESAVVEDLLYVLVGVDGRYITAQPLAGRQNRTFLVDPNLDLS------IRELVNRILPVAASY 270

  Fly   320 LRLSSRTKW----NNIAEMRLERPLNRAMRETIMDYL-------STTRQFLLSLQADSLFQLLNN 373
               |:.|::    ::....::...|..|||..:.:||       ...||.|||||  .|:..:..
Mouse   271 ---STVTRFIEEKSSFEYGQVNHALAAAMRTLVKEYLILVTQLEQLHRQGLLSLQ--KLWFYIQP 330

  Fly   374 TSTAIQLLCQLDRMFENEPRLNLNTG--ITGSFLLSSIWLAIDTCGNKDFLHLLIYFLRCISRNY 436
            ....|.:|..|        ..:::.|  :.||.|......:.:..|:.....|.:|..:..|..|
Mouse   331 AMRTIDILASL--------ATSVDKGECVGGSTLSLLHDRSFNYTGDSQAQELCLYLTKAASAPY 387

  Fly   437 FIQLQRWIYHGELDESVNEIFISRCLNTSPSFTNQCSKEFFDKSYQVDNEAIPEFLVGCEEEILQ 501
            |..|::|||.|.:.:..:|..:..............:.:::|:.|.|..:.||.||.....:||.
Mouse   388 FEILEKWIYRGIIHDPYSEFMVEEHELRKEKIQEDYNDKYWDQRYTVLPQQIPSFLQKVAGKILS 452

  Fly   502 CGKYNLVLRAYNAQHPVFDVQYP---DIVVCLTEQQLKNMRRNLADKYAIIYKRFGWCSMQSIFE 563
            .|||..|:|  ...|   ||..|   :|:..|.|:.....          |.|.|.:.| :.:.:
Mouse   453 TGKYLNVVR--ECGH---DVTCPVAKEIIYTLKERAYVEQ----------IEKAFNYAS-KVLLD 501

  Fly   564 DRMATKRVFANLMVKRTQAHLDAWAQKQRELQIKANAQKKLQND------QLNAEQERIQQNHLE 622
            ..|..|.:.|:|...:....:|                   |.|      .|..|:       |.
Mouse   502 FLMEEKELVAHLRSIKRYFLMD-------------------QGDFFVHFMDLTEEE-------LR 540

  Fly   623 KRRQDIVNELAFQRECERMEDKLLEREKQELQKKVVQLAAVLSSSPDRSTVSDLSFASCIEEPDC 687
            |..:||:                           :.:|.|:|..:...||
Mouse   541 KPVEDII---------------------------LTRLEALLELALRMST--------------- 563

  Fly   688 LAESSSDKDDANTENSEDEATKQLDKTLNVPLEQPEAEYQADVDVDQPRGKECSLPNV----FQY 748
             |.:...|||...|....:...||.:.|.:..:|.:|...||       ..|.:|..:    |.|
Mouse   564 -ANTDPFKDDLKIELMPHDLITQLLRVLAIETKQEKAMTHAD-------PTELTLSGLEAFSFDY 620

  Fly   749 QRSH--SDVINSNEHPTTQAEF-------------------NRN-RQHGLSSDQ----------- 780
            ....  |.:||.......|..|                   |:. :||.|.|.:
Mouse   621 MVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQLCSVWISNKTAKQHALHSAKWFAGAFTLRQR 685

  Fly   781 -------------FQQCHATVHLQESDLLKTAASTSSGLHAEIPQDINANLNCPDTKELTELQRN 832
                         |:....|.|:.|.: ||:|::....|
Mouse   686 MLNFVQNIQYYMMFEVMEPTWHILEKN-LKSASNIDDVL-------------------------- 723

  Fly   833 RKRNEHHDGFFSFNSTED---------EHTHRLRSLLNSNTERGRNRLRVMETEFGLGYKNTDIE 888
                .||..|.. |..:|         :...:|.|:....|...:...:.|:.:..||....|..
Mouse   724 ----GHHTSFLD-NCLKDCMLTNPELLKVFSKLMSVCVMFTNCMQKFTQSMKLDSELGRLTLDQG 783

  Fly   889 TKATPCLPLEIDKLHVEIPLAVLTPMSTTSDVDFGDPSPRELPEIAD----TANN--NNVSGSIE 947
            :...|  |.|.:::. :.|...||....:..||        .|::|.    |.||  .|.|..:.
Mouse   784 SVQGP--PTETERIE-DRPRKELTRKHLSEHVD--------APQLASGFEATINNFDKNFSAHLL 837

  Fly   948 SLSPELPKPVLAIAK----PTSLLPKLDF-GMKDER----ETEQDRDKVSTLPEACNP 996
            .|...|  .|.:.:.    ..|::.:||| |...||    ..|:.:.....:|....|
Mouse   838 DLLARL--SVYSTSDCEHGMASVISRLDFNGFYAERLERLSAERSQKAAPQVPVPRGP 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip163	NP_648537.2	GCP_N_terminal	273..523	CDD:465456	59/265 (22%)
		EnvC	<532..>677	CDD:443969	23/150 (15%)
		GCP_C_terminal	1033..1335	CDD:461187
Tubgcp2	NP_598516.2	GCP_N_terminal	218..506	CDD:465456	69/322 (21%)
		GCP_C_terminal	509..868	CDD:461187	85/479 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	877..905		3/17 (18%)