Protein Alignment Grip163 and Tubgcp6

DIOPT Version :10

• Sequence 1: NP_648537.2
• Gene: Grip163 / 39365
• FlyBaseID: FBgn0026432
• Length: 1351
• Species: Drosophila melanogaster
• Sequence 2: NP_001102218.2
• Gene: Tubgcp6 / 362980
• RGDID: 1307743
• Length: 1763
• Species: Rattus norvegicus
• Alignment Length: 1591
• Identity: 315/1591 - (19%)
• Similarity: 557/1591 - (35%)
• Gaps: 458/1591 - (28%)

  Fly   150 LQLQPYSDILTTSNLNINFPPEKLIPKIIPSTVIRMGLSESITRMRNEMEKPMHPPPRL--PVLA 212
            |.|.|..|....|.|.|.      :|:|:.........|.|.....::.|..|.|...|  .||.
  Rat   229 LDLPPVPDSADFSGLAIK------VPQIVDQWEDEGFQSASNLTPDSQSEPSMTPDLDLWEAVLT 287

  Fly   213 KKV----------VAPLEDERPFVAQPGPEKHFVSDKLLTNELK-----ILRNKNLVLNYLDEAT 262
            .:.          ..|...|.|::.:.|.:......:|...||:     :|:....||  ::|:.
  Rat   288 YEASKRRCWERIGCPPGHREEPYLTEAGRDAFDRFCRLCHGELQALSGGLLQTPRPVL--VEESE 350

  Fly   263 LIDHLKKAACGIESLTFPI---SSADKLELRVRPNTTLPTMLPEVLADFANHFIRAGCAFLRLSS 324
            |:........|:.|.||.:   :.|..:|..|..:...|..:..:|::.|.:    |..:.|||.
  Rat   351 LVKDSLNVLLGVVSATFSLCQPTQAFVVEPGVHVSGASPESISSILSEVAEY----GTCYTRLSH 411

  Fly   325 RTKWNNIAEMRLERPLNRAMRETIMDYLSTTRQFLLS-------LQADSLFQLLNNTSTAIQLLC 382
            .:....:..:.....:.:|....:..||...|..:||       |....||:.|......:..||
  Rat   412 FSLQPVVGSLCSRGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELC 476

  Fly   383 QLDRM---FENEPRLNLNTGITGSFLLSSIWL-AIDTCGNKDFLHLLIYFLRCISRNYFIQLQRW 443
            .:..:   ...|||....||:.   |||.::. |:|.|.|:.: .:|:..|:.....|...:..|
  Rat   477 GVGTVSLATSGEPRAVFPTGVK---LLSYLYQEALDNCSNEHY-PVLLSLLKTSCEPYTRFIHDW 537

  Fly   444 IYHGELDESVNEIFISRCLNTSPSFTNQCSKEFFDKSY----------QVDNEAIPEFLVGCEEE 498
            :|.|...:...|..|.         .|.....|.||.|          :|: :.:|.||.....:
  Rat   538 VYSGVFRDVYGEFMIQ---------VNHEYLSFRDKFYWTHGYVLISKEVE-DCVPVFLKHIAHD 592

  Fly   499 ILQCGKYNLVLRAYNAQHPV--FDVQYPDIVVCLTEQQLKNMRRNLA---------DKYAIIYK- 551
            :..|||...:|:....:|.:  .||..|.|.|..:.::||.:.::.|         .:|:.|.|
  Rat   593 VYVCGKTINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARYSSISKE 657

  Fly   552 ----RFGWCSMQSIFEDRMATKRVFANLMVKRTQAHLDAWAQKQRELQIKANAQKKLQNDQLNAE 612
                |......:.|...|.|..||.:.|            :.:|...||..:.:|:.|..:|..:
  Rat   658 EKELRMEIAKQELIVHAREAASRVLSEL------------SDRQMSEQIALDTRKREQFQRLKEQ 710

  Fly   613 QERIQQNHLEKRRQDIVNELAFQRECERMEDKLLEREKQELQKKVVQ--------LAAVLSSSPD 669
            ..:.|:..|..|::::.::.::..|. |..:|.|:..::||::|..|        |:|..:....
  Rat   711 FVKDQERRLAARQEELGDDFSYAHEL-RAREKRLKALEEELERKARQALVDHYSKLSAEAARREQ 774

  Fly   670 -------RSTVSDLSFASCIEEPDCLAESSSDKDDANTENSEDEATKQLDKTLN-VPLEQPEAE- 725
                   |..:........:|:..|:.|...|.:    .:...|....|..|.: |....||.|
  Rat   775 KALWRIRRHRLESARLRFLLEDQKCIQEMLRDME----AHQPQEPLSVLPSTCSQVTSLGPEHEG 835

  Fly   726 --YQADVDVDQPR----GKEC-SLPNV-------------FQYQRSHSDVI---NSNEHPT---- 763
              :..|::..:.|    .:.| |.|:|             |....|.:|.:   :.:|.|.
  Rat   836 EGHSCDLESTELRCDCSNQPCASTPSVLKSGAGQAEEAGPFSTGLSITDFLPMGSGDEQPVGDTG 900

  Fly   764 -------------------------------TQAEFNRN-------------------------- 771
                                           ||:|::.|
  Rat   901 APFLEVALQSICSDLSPITPGPALTAGGLQPTQSEYDFNTILRPAMATPPLPGPFRDVQNSVDSE 965

  Fly   772 RQHGLSSDQFQQCHATVH-LQES-------------------------DLLKTAASTSS------ 804
            :|| |..|...:..:.:| :||:                         .:.:|..:|.|
  Rat   966 KQH-LLRDMPTKPDSCIHDMQETLPCLHPLSHVTPAEGSLQPVGQLLEHMSETTVATESHASGMA 1029

  Fly   805 --------------------------------GLHAEIPQ-DINANLNCPDT------------- 823
                                            .:|..:.: :|....|..|.
  Rat  1030 PCQQLSISRHVSDANIKVGDYMSDVALPRPRWNIHGHVSEANIGVGENVSDVAPSRPRWNVHGHV 1094

  Fly   824 --------KELTELQRNRKR-NEH---HDGFFSFNSTEDE----------HTHRLRSLLNSNTER 866
                    :.::::..:|.| |.|   .|..........|          |.|    :.:::.:.
  Rat  1095 SDASIKVGENVSDVAPSRPRWNVHGHVSDASIKVGENVSEVAPSRPRWNVHGH----VSDASIKV 1155

  Fly   867 GRN-------RLR------VMETEFGLGYKNTDIETKATPCLPLEIDKLHVEIPLAVLTPMSTTS 918
            |.|       |.|      |.:....:|...:|:    .|..|..  .:|..:..|.:......|
  Rat  1156 GENVSDVAPSRPRWNVHGHVSDASIKVGENVSDV----APSRPRW--NVHGHVSEASIRIGENVS 1214

  Fly   919 DVD------------FGDPSPRELPEI-ADTANNNNVSGSI---------ESLSPELP---KPVL 958
            |||            ..:|.|...|:: :.....::||.::         :...|:||   ||.:
  Rat  1215 DVDLQPHGHVQPPLILEEPFPEAEPDLKSHQCPPDHVSQTVLCVEAQSPAQECEPQLPEEMKPTI 1279

  Fly   959 AIA----KPTSLLPK--------LDFGMKDERETEQDRD------------KVSTLPEACNPF-- 997
            .::    :..||..|        |..|:.:|:...::||            :..|||.:..|.
  Rat  1280 CLSLGSTEEGSLQTKTLVTEPSMLGNGIPEEKGPRRNRDAEDLSPCLPSSPQEDTLPSSPGPSEE 1344

  Fly   998 -------MARR------------------------------------------------------ 1001
                   .|||
  Rat  1345 VPSTEAEEARRWGKEQAYLADLTKLYRLEQYPDSYESMSEPPMAHLVHHMLPRAFAFPVDPQVQS 1409

  Fly  1002 -----CLQL------------SVMAPLNAYYGLLRNEVL-RIFQEQRIYEHFRKLRNYFFLVDGQ 1048
                 .:||            |:||||.|:..|:....: ..|.|..:..||..||::..:.||:
  Rat  1410 AVDESAVQLSELLTLPVLMKRSLMAPLAAHVSLVNKAAVDYFFVELHLETHFEALRHFLLMEDGE 1474

  Fly  1049 FGATLTNEILGRIRAGVGPRSLSQKGILDTILTNALAACSADETTVSENLTLNCTTIPDTLNFLS 1113
            |..:|::.:..::.||..|..|....:|::||:.||......:|..:.||:.....:|:.....:
  Rat  1475 FAQSLSDLLFEKLGAGQTPGELLNPLVLNSILSKALQYSLHGDTPHATNLSFALKYLPEVFAPNA 1539

  Fly  1114 VEATSMLKLNCKIDWPLNMVISSETISKYGQIFGYLLKLRHVSFVLDGTYEYLQQMGKLLGPELR 1178
            .:..|.|:|..|:|||||:||:...::||..||.:||:|:.:.:.|.....:|::..  |.....
  Rat  1540 PDVLSCLELRYKVDWPLNIVITESCLNKYSGIFSFLLQLKLMMWTLKDICFHLKRTA--LVSHTA 1602

  Fly  1179 TCTHFRHMQMMRHKMSHFMTSFQTHLVAKALLSTWKSFKEELCTADSIEALYKQHVAYLKRVAFL 1243
            ....||.:|:.:|:|.||:...|.::..:.|..:|..|:..|.....:|.:.:.|..||.|..|.
  Rat  1603 GSVQFRQLQLFKHEMQHFVKVIQGYIANQILHVSWCEFRARLAVVGDLEEIQRAHAEYLHRAVFR 1667

  Fly  1244 ALLNRRSAKVKETIDNILVIILRFCKVIQSQSF-IVDQDNYFVHPRFKRLQQEEAEFEKFLQYLI 1307
            .||..::|.|...|.:|..::|:|...:.||:: .........||.|..:||..:.|:.:..:|.
  Rat  1668 GLLTEKAAPVMNIIHSIFSLVLKFRSQLISQNWGPATGPRGAEHPNFPLMQQSYSTFKYYSHFLF 1732

  Fly  1308 YLGNKAAASGYQEEIGDLICIINFNHYYKVS 1338
            .:..|....|||..:.|.:..||||:||:.|
  Rat  1733 KVVTKLVNRGYQPHLEDFLLRINFNNYYQDS 1763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip163	NP_648537.2	GCP_N_terminal	273..523	CDD:465456	62/275 (23%)
		EnvC	<532..>677	CDD:443969	33/173 (19%)
		GCP_C_terminal	1033..1335	CDD:461187	86/302 (28%)
Tubgcp6	NP_001102218.2	GCP6_N	28..341	CDD:466048	25/117 (21%)
		GCP_N_terminal	352..631	CDD:465456	65/296 (22%)
		TPH	628..>811	CDD:464007	37/199 (19%)
		DUF4573	1044..1199	CDD:434493	21/164 (13%)
		GCP_C_terminal	1460..1760	CDD:461187	86/301 (29%)