Protein Alignment Grip163 and Tubgcp2

DIOPT Version :10

• Sequence 1: NP_648537.2
• Gene: Grip163 / 39365
• FlyBaseID: FBgn0026432
• Length: 1351
• Species: Drosophila melanogaster
• Sequence 2: NP_001101030.1
• Gene: Tubgcp2 / 309098
• RGDID: 1309597
• Length: 905
• Species: Rattus norvegicus
• Alignment Length: 1095
• Identity: 205/1095 - (18%)
• Similarity: 358/1095 - (32%)
• Gaps: 340/1095 - (31%)

  Fly    12 LDLVTKMATMLVADEMKPKKQTAVLVAKKRSKIYESLLHSETMSSQDKLEMLHQVTSEVAKNPDR 76
            :||:.|..|        |...|.|.....:.||.|.     :.:.:|.|:...::.|:..:|.|.
  Rat    29 IDLLQKNRT--------PYVTTTVSAHSAKVKIAEF-----SRTPEDFLKKYDELKSKNTRNLDP 80

  Fly    77 MDMLLRFQNLLEGQDKEESEITQDQDEENQSEVVIKRIKAGPLQLIETIEIVEEALHPKAFPDIN 141
            :..||             |::|:|:                     ||::.:::....:|
  Rat    81 LVYLL-------------SKLTEDK---------------------ETLQYLQQNAKERA----- 106

  Fly   142 QMNRALKPLQLQPYSDILTTSNLNINFPPE--KLIPKIIPSTVIRMGLSESITRMRNEMEKPMHP 204
            ::..:........:|..:..|.::.....|  |.:..:...:.::..|..:...:|::..|....
  Rat   107 ELAASAAASSATGFSIPVAASKMSTQELEELRKQLGSVATGSTLQQSLELTRKMLRDKQNKKNSG 171

  Fly   205 PPRLPVLAKKVVAPLEDERPFVAQPGPEKHFVSDKLLTNELKILRNKNLVLNYL----DEATLID 265
            .| |||....|.     |||.:|         .|.|:.:.|.  .:..|.:..|    .|:.:::
  Rat   172 QP-LPVFPAWVY-----ERPTLA---------GDFLIGSGLS--SDTTLPIGTLPLASQESAVVE 219

  Fly   266 HLKKAACGIES---LTFPISSADKLELRVRPNTTLPTMLPEVLADFANHFIRAGCAFLRLSSRTK 327
            .|.....|::.   ...|::........|.||..|.      :.:..|..:....::   |:.|:
  Rat   220 DLLYVLVGVDGRYITAQPLAGRQNRTFLVDPNLDLS------IRELVNRILPVAASY---STVTR 275

  Fly   328 W----NNIAEMRLERPLNRAMRETIMDYL-------STTRQFLLSLQADSLFQLLNNTSTAIQLL 381
            :    ::....::...|..|||..:.:||       ...||.|||||  .|:..:......|.:|
  Rat   276 FIEEKSSFEYGQVNHALAAAMRTLVKEYLILVTQLEQLHRQGLLSLQ--KLWFYIQPAMRTIDIL 338

  Fly   382 CQLDRMFENEPRLNLNTG--ITGSFLLSSIWLAIDTCGNKDFLHLLIYFLRCISRNYFIQLQRWI 444
            ..|        ..:::.|  :.||.|......:.:..|:.....|.:|..:..|..||..|:.||
  Rat   339 ASL--------ATSVDKGECVGGSTLSLLHDRSFNYTGDSQAQELCLYLTKAASAPYFEILEEWI 395

  Fly   445 YHGELDESVNEIFISRCLNTSPSFTNQCSKEFFDKSYQVDNEAIPEFLVGCEEEILQCGKYNLVL 509
            |.|.:.:..:|..:..............:.:::|:.|.|..:.||.||.....:||..|||..|:
  Rat   396 YRGVIHDPYSEFMVEEHELRKEKIQEDYNDKYWDQRYTVLPQQIPSFLQKVAGKILSTGKYLNVV 460

  Fly   510 RAYNAQHPVFDVQYP---DIVVCLTEQQLKNMRRNLADKYAIIYKRFGWCSMQSIFEDRMATKRV 571
            |  ...|   ||..|   :|:..|.|:.....          |.|.|.:.|
  Rat   461 R--ECGH---DVTCPVAKEIIYTLKERAYVEQ----------IEKAFNYAS-------------- 496

  Fly   572 FANLMVKRTQAHLDAWAQKQRELQIKANAQKKLQNDQLNAEQERIQQNHLEK-RRQDIVNELAFQ 635
                                           |:..|.|..|:|.:.  ||.. :|..::::..|.
  Rat   497 -------------------------------KVLLDFLMEEKELVA--HLRSIKRYFLMDQGDFF 528

  Fly   636 RECERMEDKLLEREKQELQKKV-----VQLAAVLSSSPDRSTVSDLSFASCIEEPDCLAESSSDK 695
            ..       .::..::||:|.|     .:|.|:|..:...||                |.:...|
  Rat   529 VH-------FMDLTEEELRKPVEDITPTRLEALLELALRMST----------------ANTDPFK 570

  Fly   696 DDANTENSEDEATKQLDKTLNVPLEQPEAEYQADVDVDQPRGKECSLPNV----FQYQRSH--SD 754
            ||...:....:...||.:.|.:..:|.:|...||       ..|.:|..:    |.|....  |.
  Rat   571 DDLKIDLMPHDLITQLLRVLAIETKQEKAMTHAD-------PTELTLSGLEAFSFDYMVKWPLSL 628

  Fly   755 VINSNEHPTTQAEF-------------------NRN-RQHGLSSDQ------------------- 780
            :||.......|..|                   |:. :||.|.|.:
  Rat   629 IINRKALTRYQMLFRHMFYCKHVERQLCSVWISNKTAKQHALHSAKWFAGAFTLRQRMLNFVQNI 693

  Fly   781 -----FQQCHATVHLQESDLLKTAASTSSGLHAEIPQDINANLNCPDTKELTELQRNRKRNEHHD 840
                 |:....|.|:.|.: ||:|::....|                              .||.
  Rat   694 QYYMMFEVMEPTWHILEKN-LKSASNIDDVL------------------------------GHHT 727

  Fly   841 GFFSFNSTEDEHTHRLRSLLNSNTERGRNRLRVMETEFGLGYKNTDIETKATPCLPLE------- 898
            .|..         :.|:..:.:|.|    .|:|......:....|:...|.|..:.|:
  Rat   728 SFLD---------NCLKDCMLTNPE----LLKVFSKLMSVCVMFTNCMQKFTQSMKLDSELGRLT 779

  Fly   899 IDKLHVEIPLAVLTPMS-TTSDVDFGDPSPRELPEIAD----------TANN--NNVSGSIESLS 950
            :|:..|:.|    .|.| ...|....:|:.:.|||..|          |.||  .|.|..:..|.
  Rat   780 LDQGSVQGP----PPESERIDDRPRKEPTRKHLPEHVDTPQLSSGFEATINNFDKNFSAHLLDLL 840

  Fly   951 PELPKPVLAIAK----PTSLLPKLDF-GMKDER----ETEQDRDKVSTLPEACNP 996
            ..|  .|.:.:.    ..|::.:||| |...||    ..|:.:.....:|....|
  Rat   841 ARL--SVYSTSDCEHGMASVISRLDFNGFYAERLERLSAERSQKAAPQVPVPRGP 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip163	NP_648537.2	GCP_N_terminal	273..523	CDD:465456	59/265 (22%)
		EnvC	<532..>677	CDD:443969	23/150 (15%)
		GCP_C_terminal	1033..1335	CDD:461187
Tubgcp2	NP_001101030.1	GCP_N_terminal	218..506	CDD:465456	71/366 (19%)
		GCP_C_terminal	509..868	CDD:461187	82/440 (19%)