Protein Alignment Grip163 and TUBGCP2

DIOPT Version :10

• Sequence 1: NP_648537.2
• Gene: Grip163 / 39365
• FlyBaseID: FBgn0026432
• Length: 1351
• Species: Drosophila melanogaster
• Sequence 2: NP_001243546.1
• Gene: TUBGCP2 / 10844
• HGNCID: 18599
• Length: 930
• Species: Homo sapiens
• Alignment Length: 766
• Identity: 156/766 - (20%)
• Similarity: 261/766 - (34%)
• Gaps: 210/766 - (27%)

  Fly    12 LDLVTKMATMLVADEMKPKKQTAVLVAKKRSKIYESLLHSETMSSQDKLEMLHQVTSEVAKNPDR 76
            :||:.|..|        |...|.|.....:.||.|.     :.:.:|.|:...::.|:..:|.|.
Human    29 IDLLQKNRT--------PYVTTTVSAHSAKVKIAEF-----SRTPEDFLKKYDELKSKNTRNLDP 80

  Fly    77 MDMLLRFQNLLEGQDKEESEITQDQDEENQSEVVIKRIKAGPLQL----------IETIEIVEEA 131
            :..||  ..|.|  |||..:..| |:.:.::|:....:.:....:          ::.:|.:.:.
Human    81 LVYLL--SKLTE--DKETLQYLQ-QNAKERAELAAAAVGSSTTSINVPAAASKISMQELEELRKQ 140

  Fly   132 LHPKAFPDINQMNRALKPLQLQPYSDILTTSNLNINFP--PEKLI--PKIIPSTVIRMGLSES-- 190
            |...|.....|.:..||...|:   |.....|...:.|  |..:.  |.:|...:|..|:|..
Human   141 LGSVATGSTLQQSLELKRKMLR---DKQNKKNSGQHLPIFPAWVYERPALIGDFLIGAGISTDTA 202

  Fly   191 --ITRMR-NEMEKP-------------MHPPPRLPVLAKKVVAPLEDERPFVAQPGPEKHFVSDK 239
              |..:| |....|             :|.|..|| ||.:..|.:||  ......|.:..:||.:
Human   203 LPIVLLRWNLALSPRLKCSGVISAHCNLHLPGTLP-LASQESAVVED--LLYVLVGVDGRYVSAQ 264

  Fly   240 LLTNELKILRNKNLVLNYLDEATLIDHLKKAACGIESLTFPISSADKLELRVRPNTTLPTMLPEV 304
            .|                              .|.:|.||.:.....|.:|...:..||     |
Human   265 PL------------------------------AGRQSRTFLVDPNLDLSIRELVHRILP-----V 294

  Fly   305 LADFANHFIRAGCAFLRLSSRTKWNNIAEMRLERPLNRAMRETIMDYL-------STTRQFLLSL 362
            .|.::     |...|:...|..::..:     ...|..|||..:.::|       ...||.||||
Human   295 AASYS-----AVTRFIEEKSSFEYGQV-----NHALAAAMRTLVKEHLILVSQLEQLHRQGLLSL 349

  Fly   363 QADSLFQLLNNTSTAIQLLCQLDRMFENEPRLNLNTGITGSFLLSSIWLAIDTCGNKDFLHLLIY 427
            |  .|:..:......:.:|..|....:....|.   |.|.|.|...   :....|:.....|.:|
Human   350 Q--KLWFYIQPAMRTMDILASLATSVDKGECLG---GSTLSLLHDR---SFSYTGDSQAQELCLY 406

  Fly   428 FLRCISRNYFIQLQRWIYHGELDESVNEIFISRCLNTSPSFTNQCSKEFFDKSYQVDNEAIPEFL 492
            ..:..|..||..|::|||.|.:.:..:|..:..............:.:::|:.|.:..:.||.||
Human   407 LTKAASAPYFEVLEKWIYRGIIHDPYSEFMVEEHELRKERIQEDYNDKYWDQRYTIVQQQIPSFL 471

  Fly   493 VGCEEEILQCGKYNLVLRAYNAQHPVFDVQYP---DIVVCLTEQQLKNMRRNLADKYAIIYKRFG 554
            ....::||..|||..|:|  ...|   ||..|   :|:..|.|:.....          |.|.|.
Human   472 QKMADKILSTGKYLNVVR--ECGH---DVTCPVAKEIIYTLKERAYVEQ----------IEKAFN 521

  Fly   555 WCSMQSIFEDRMATKRVFANLMVKRTQAHLDAWAQKQRELQIKANAQKKLQNDQLNAEQERIQQN 619
            :.|                                             |:..|.|..|:|.:.
Human   522 YAS---------------------------------------------KVLLDFLMEEKELVA-- 539

  Fly   620 HLEK-RRQDIVNELAFQRECERMEDKLLEREKQELQKKV-----VQLAAVLSSSPDRSTVSDLSF 678
            ||.. :|..::::..|...       .::..::||:|.|     .:|.|:|..:...||
Human   540 HLRSIKRYFLMDQGDFFVH-------FMDLAEEELRKPVEDITPPRLEALLELALRMST------ 591

  Fly   679 ASCIEEPDCLAESSSDKDDANTENSEDEATKQLDKTLNVPLEQPEAEYQAD 729
                      |.:...|||...:....:...||.:.|.:..:|.:|...||
Human   592 ----------ANTDPFKDDLKIDLMPHDLITQLLRVLAIETKQEKAMAHAD 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip163	NP_648537.2	GCP_N_terminal	273..523	CDD:465456	61/256 (24%)
		EnvC	<532..>677	CDD:443969	23/150 (15%)
		GCP_C_terminal	1033..1335	CDD:461187
TUBGCP2	NP_001243546.1	GCP_N_terminal	246..534	CDD:465456	78/402 (19%)
		GCP_C_terminal	537..893	CDD:461187	24/121 (20%)