Protein Alignment CG6938 and ANO8

DIOPT Version :10

• Sequence 1: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Sequence 2: NP_066010.1
• Gene: ANO8 / 57719
• HGNCID: 29329
• Length: 1232
• Species: Homo sapiens
• Alignment Length: 969
• Identity: 200/969 - (20%)
• Similarity: 301/969 - (31%)
• Gaps: 450/969 - (46%)

  Fly   465 QTLLEG----------ETTFKAATANGNPEEQFI---VKDRATAFTSAQRSLMVM---------- 506
            ::||.|          :..|...|...:.||.||   |:.....|||.:|..::.
Human   116 ESLLRGADELGLRKAVKAEFGGGTRGFSCEEDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQ 180

  Fly   507 -QVLIRTPFDESDRSGIRRLMNDGTYLGCFPLHEGRYDRPHSSGISLDRRVLYQTWAHPSQWYKK 570
             :.|....|.| |:..|..|...|.....||:||.|.         |:|  |.::|....  .:.
Human   181 GEALHNVRFLE-DQPIIPELAARGIIQQVFPVHEQRI---------LNR--LMKSWVQAV--CEN 231

  Fly   571 QPLCLVRKYFGDKIALYFCWLGFYTEMLVYPAVVGTLCFIYGLATLESEDNTPSKEICNEYGTGN 635
            |||..:..|||.|||:||.||||||..:|||||.|::.:.:      :|.:..|:::
Human   232 QPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTF------TEADQTSRDV-------- 282

  Fly   636 ITLCPLCDKACSYQRLSESCLFSRLTYLFDNPSTVFFAIFMSFWATTFLELWKRKQSVLVWEWDL 700
                              ||              |.||:|...|:|.|||.|||:.:.|.::|.
Human   283 ------------------SC--------------VVFALFNVIWSTLFLEEWKRRGAELAYKWG- 314

  Fly   701 HNVDMD----EENRPEFETNATTFRMNPVTREKEPYMSTWNRSIRFVITGSAVLFMISVVLSAVL 761
             .:|..    ||.||:|.   ...|::|:||.:|.|...|.|          :||.:.|.|...|
Human   315 -TLDSPGEAVEEPRPQFR---GVRRISPITRAEEFYYPPWKR----------LLFQLLVSLPLCL 365

  Fly   762 GTILYRITLVSVIYGGGGFFVKEHAKLFTSV-----TAALINLVVIMILTRI----YHRMAIKLT 817
            ..::....|:.     |.|.::|   |..||     .|..:..|::.:|..:    |.::||.|.
Human   366 ACLVCVFLLML-----GCFQLQE---LVLSVKGLPRLARFLPKVMLALLVSVSAEGYKKLAIWLN 422

  Fly   818 NLENPRTHTEYEDSYTFKIFFFEFMNFYSSLIYIAFFKGRFFDYPGDDQARKSEFFRLKNDICDP 882
            ::||.|..:.||.....|:..|:|:|.|.||.||.|:              ..:..|||.
Human   423 DMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFY--------------LKDMERLKE----- 468

  Fly   883 AGCLSELCIQLAIIMVGKQCWNNFMEYLFPKFWNWWRQRKHKQATKDESHLHMAW---------- 937
                     .||.:::.:|...|..|.|.|..        :::..:.|..|...|
Human   469 ---------MLATLLITRQFLQNVREVLQPHL--------YRRLGRGELGLRAVWELARALLGLL 516

  Fly   938 ----------------------------------------------------------------- 937
                                                                             
Human   517 SLRRPAPRRLEPQADEGGGGGSGGGGRRCLSGGCGAPEEEEEAALVERRRAGEGGEEGDGPPGGK 581

  Fly   938 ---EQDYHMQD------------------------------------------------------ 945
               |.|...:|
Human   582 EEDEDDEEEEDEEEEEDEEEGEEGGLLDCGLRLKKVSFAERGAGRRRPGPSPEALLEEGSPTMVE 646

  Fly   946 ----PGRLAL------------------------------------------------------- 951
                ||...|
Human   647 KGLEPGVFTLAEEDDEAEGAPGSPEREPPAILFRRAGGEGRDQGPDGGPDPEPGSNSDSTRRQRR 711

  Fly   952 ---------------------------------FDEYLEMILQYGFVTLFVAAFPLAPLFALLNN 983
                                             |.:|.||.:|:|:|.||.:|||||.|.||:||
Human   712 QNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNN 776

  Fly   984 VAEIRLDAYKMVTQARRPLAERVEDIGAWYGILRIITYTAVVSNAFVIAYTSDFIPRMVYKFVYS 1048
            :.|||.||:|:.|..:||..:|||.||.|..::..:...|:|.|.::|..
Human   777 LIEIRSDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQ--------------- 826

  Fly  1049 ETHTLAGYIEHSLSIFNTSDYKEEWGASVSEKDPDTCQYRGYRNGPKDYEPYGLSPHYWHVFAAR 1113
                 .|.::.   :|       .|                            |||.      |.
Human   827 -----CGQLQR---LF-------PW----------------------------LSPE------AA 842

  Fly  1114 LAFVVVFEHVVFVITGIMQFIIPDVPSEVKTQM------QREQLLAKEAKYQHGIKRAQ 1166
            :..|||.||...::..::...|||:|..|..:|      :||.....|.:.||..::.|
Human   843 IVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHERQAQHRYQQQQ 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	31/131 (24%)
		Anoctamin	576..1149	CDD:461349	161/815 (20%)
ANO8	NP_066010.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		Anoctamin	237..>497	CDD:461349	96/364 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	524..650		3/125 (2%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	681..728		0/46 (0%)
		Anoctamin	<717..877	CDD:461349	56/223 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	888..970		4/14 (29%)
		PHA03307	<940..>1120	CDD:223039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	997..1152
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1174..1232