Protein Alignment CG6938 and ano8b

DIOPT Version :10

• Sequence 1: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Sequence 2: XP_691248.6
• Gene: ano8b / 562782
• ZFINID: ZDB-GENE-121024-1
• Length: 1110
• Species: Danio rerio
• Alignment Length: 1087
• Identity: 223/1087 - (20%)
• Similarity: 374/1087 - (34%)
• Gaps: 386/1087 - (35%)

  Fly   295 DTASSVSGSYYGSRKASK-SNSLGGESGDERRVSKQDREGLDPESLMFRDGRRKVDMVLAWEEED 358
            |||::.:.|     .||. |:|..|||...|..::.|.|..:.:           ....|.:...
Zfish     4 DTAAAAAAS-----SASNISSSSDGESSRLRHRAQGDAERAEQQ-----------QHTAAPQTTS 52

  Fly   359 LGVMTEAEAKRR-------DNRRSFMENLIKEGLEVELEDKSQSFNEKTFFLKIHLPWRLETRLA 416
            .||:.:...||.       .:.:|:|:.:..|..:|.:.....:.:....:|..|:...:...:.
Zfish    53 AGVLDKLFGKRLLQAGRHIMSHKSWMKTVPTENCDVLMTFPDTTDDHTLLWLLNHIRLGIPELII 117

  Fly   417 EVMNLKLPVKRFITISVKPSWDEENVVLRNMQYWKDVWQRLTKKIQLDQTLLEGETTFKAATANG 481
            ::.:.|  ..|.....|..::  ||::            |..:::.|.:.:   :..|...:.:.
Zfish   118 QIRHHK--HTRMYAFFVTATY--ENLL------------RGAEEMGLQKAV---KPEFGGGSRSF 163

  Fly   482 NPEEQFI---VKDRATAFTSAQRSLMVMQVL--IRTPFDES--------DRSGIRRLMNDGTYLG 533
            :.||.:|   ::.....|||.:|..::...|  :|....|:        .:..|..|...|....
Zfish   164 SCEEDYIYENIESELCFFTSQERQSIIKYWLDNLRAKHGEALHNIHFLEGQPIIPELRARGVIQQ 228

  Fly   534 CFPLHEGRYDRPHSSGISLDRRVLYQ---TWAHPSQWYKKQPLCLVRKYFGDKIALYFCWLGFYT 595
            .|||||              :|:|.|   :|....  .:||||..:..|||.|||:||.||||||
Zfish   229 VFPLHE--------------QRILGQLMKSWVQAV--CEKQPLDDICDYFGVKIAMYFAWLGFYT 277

  Fly   596 EMLVYPAVVGTLCFIYGLATLESEDNTPSKEICNEYGTGNITLCPLCDKACSYQRLSESCLFSRL 660
            ..::||||:|   |:..:.|   |.:..|::||                          |
Zfish   278 TSMLYPAVIG---FVLWMLT---ESDQTSRDIC--------------------------C----- 305

  Fly   661 TYLFDNPSTVFFAIFMSFWATTFLELWKRKQSVLVWEWDLHNVDMD--EENRPEFETNATTFRMN 723
                     |.||:|...|||.|||.|||:.:.|.::|...|...:  ||.||:|.   ...|.:
Zfish   306 ---------VVFALFNVVWATLFLERWKRRGAELAYKWGTLNTPAESLEEPRPQFR---GVKRCS 358

  Fly   724 PVTREKEPYMSTWNRSI-RFVITGSAVLFMISVVLSAVLGTILYRITLVSVIYGGGGFFVKEHAK 787
            |||..:|.|...|.|.: |::::....:..:..|..|:|  :.:.  |...:.|     :||..:
Zfish   359 PVTGCEEFYYPPWRRRVFRWLVSFPVCILCLCFVFLAML--VCFE--LQEFVMG-----IKELPR 414

  Fly   788 LFTSVTAALINLVVIMILTRIYHRMAIKLTNLENPRTHTEYEDSYTFKIFFFEFMNFYSSLIYIA 852
            :...:...:: .:.:.....:|.::|..|.::||.|..:.||.:...|:..|:|:|.|.||.||.
Zfish   415 VARFIPKIML-AITVTACDEVYRKIACWLNDMENYRLQSAYEKNLIIKMVLFQFVNSYLSLFYIG 478

  Fly   853 FFKGRFFDYPGDDQARKSE----------FFRLKNDICDP----AGCLSELCIQL-------AII 896
            |:.        .|..|..|          |.:...::..|    ...|.||.::.       |::
Zfish   479 FYL--------KDMERLKEMLATLLIIRQFVQNMKEVLQPYLAERHRLGELTLRAVWELLVSALL 535

  Fly   897 MVG------------------------------------KQCWN--------------------- 904
            ..|                                    ::|.|
Zfish   536 KYGRLAAGRAQVSPSDPTVLGPGLRGPQMGEEGHQDRRERKCLNGGCGVPDEDMEEEHGERHSEE 600

  Fly   905 ------------------------------------NFMEYLFP--------------------- 912
                                                :|:|...|
Zfish   601 ENESESLIDCGLKLRKVSFIEKVERKSASCVSPVDDSFLEEGSPTMVERGMDPASVFEMCDDEDE 665

  Fly   913 ------------------------KFWNWWRQRKHKQATKDESHLHMAWEQDYHMQDPGRLA--- 950
                                    |.    |:|.......|......:|......|:...|.
Zfish   666 NGAPEMKELAAEPLPTGVENSSSVKL----RKRGRSLERADSKTKRDSWMDPPEEQETNTLTQAE 726

  Fly   951 ----------LFDEYLEMILQYGFVTLFVAAFPLAPLFALLNNVAEIRLDAYKMVTQARRPLAER 1005
                      .|.:|.||.:|:|:|.||.:|||||.:.||:||:.|||.||:|:.|..:||...|
Zfish   727 VEGCMQTYQDTFQDYQEMFVQFGYVVLFSSAFPLAAMCALINNIIEIRSDAFKLCTSLQRPFGLR 791

  Fly  1006 VEDIGAWYGILRIITYTAVVSNAFVIAYTSDFIPRMVYKFVYSETHTLAGYIEHSLSIFNTSDYK 1070
            |..||.|..::..:...|::.|.::|..                    .|.::.   :|
Zfish   792 VASIGQWQTVMEAMGLIAIIVNCYLIGQ--------------------CGQLQR---LF------ 827

  Fly  1071 EEWGASVSEKDPDTCQYRGYRNGPKDYEPYGLSPHYWHVFAARLAFVVVFEHVVFVITGIMQFII 1135
             .|                            |||.      ..:..:|:.||...::..|:...|
Zfish   828 -PW----------------------------LSPE------MAIISIVILEHFAVLLKYIIHVAI 857

  Fly  1136 PDVPSEVKTQMQREQLLAKEAKYQHGIKRAQGDSQDIMSLFRDTSNR 1182
            ||:||.|..:|.:.:...|||..:|. ::||...|......|:...|
Zfish   858 PDIPSWVGEEMAKLEFQRKEAFKKHE-RQAQQHFQQQQRRKREEEER 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	43/255 (17%)
		Anoctamin	576..1149	CDD:461349	155/747 (21%)
ano8b	XP_691248.6	Anoctamin	258..870	CDD:461349	155/746 (21%)