Protein Alignment CG6938 and ANO10

DIOPT Version :10

• Sequence 1: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Sequence 2: NP_001333393.1
• Gene: ANO10 / 55129
• HGNCID: 25519
• Length: 699
• Species: Homo sapiens
• Alignment Length: 679
• Identity: 180/679 - (26%)
• Similarity: 272/679 - (40%)
• Gaps: 187/679 - (27%)

  Fly   519 RSGIRRLMNDGTYLGCFPLHEGRYDRPHSSGISLDRRVLYQTWAHPSQWYKKQPLCLVRKYFGDK 583
            :|.:|||:..|..:..||||:           |...:.|..|| :.....|.||:..:|.|||:.
Human   155 KSLLRRLLTSGIVIQVFPLHD-----------SEALKKLEDTW-YTRFALKYQPIDSIRGYFGET 207

  Fly   584 IALYFCWLGFYTEMLVYPAVVGTLCFIYGLATLESEDNTPSKEICNEYGTGNITLCPLCDKACSY 648
            |||||.:|.::|..|:..||:|...:::               :..:|           ||
Human   208 IALYFGFLEYFTFALIPMAVIGLPYYLF---------------VWEDY-----------DK---- 242

  Fly   649 QRLSESCLFSRLTYLFDNPSTVFFAIFMSFWATTFLELWKRKQSVLVWEW-DLHNVDMDEENRPE 712
                                .|.||.|...|:|..||||||..:.:.:.| .|......||.||.
Human   243 --------------------YVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPG 287

  Fly   713 FETNATTFRMNPVTREKEPYMSTWNRSIRFVITGSAVLFMISVVLSAVLGTILYRITLVSVIYGG 777
            |.   ....:|.:|.::||...::.|.:|        ::::|:....:   .||....|.:||
Human   288 FH---GVLGINSITGKEEPLYPSYKRQLR--------IYLVSLPFVCL---CLYFSLYVMMIY-- 336

  Fly   778 GGFFVKEHAKL---------FTSV---TAALINLVVIMILTRIYHRMAIKLTNLENPRTHTEYED 830
               |..|...|         :|||   ..::|..:||.|:.|:|...|..||:.||.|..:.|::
Human   337 ---FDMEVWALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQN 398

  Fly   831 SYTFKIFFFEFMNFYSSLIYIAFFKGRFFDYPGDDQARKSEFFRLKNDICDPAGCLSELCIQLAI 895
            ....|:..|.|:|.::||.||||.                    ||:        :..|...||.
Human   399 HLILKVLVFNFLNCFASLFYIAFV--------------------LKD--------MKLLRQSLAT 435

  Fly   896 IMVGKQCWNNFMEYLFPKFWNWWRQRKH-------KQATKDESHLHMAWEQDYHMQDPGR-LALF 952
            :::..|..|..||...|    :|.||||       .||.|.:....: :||....::.|. |..|
Human   436 LLITSQILNQIMESFLP----YWLQRKHGVRVKRKVQALKADIDATL-YEQVILEKEMGTYLGTF 495

  Fly   953 DEYLEMILQYGFVTLFVAAFPLAPLFALLNNVAEIRLDAYKMVTQARRPLAERVEDIGAWYGILR 1017
            |:|||:.||:|:|:||...:|||..||:|||..|:..||.||....:||.:|...:||.|..|..
Human   496 DDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQIIFC 560

  Fly  1018 IITYTAVVSNAFVIAYTSDFIPRMVYKFVYSETHTLAGYIEHSLSIFNTSDYKEEWGASVSEKDP 1082
            :.|......|..|:                   ..|.|.:|.|..:|..        ..||:...
Human   561 LDTGVKRGLNCKVM-------------------RNLLGEMEMSCVLFVV--------VVVSQLAF 598

  Fly  1083 DT---------CQYRGYRNGPKDYEPYGLSPHYWHVF----AARLAFVVVFEHVVFVITGIMQFI 1134
            :|         |..            .|:||....||    |..:..||..||.:..:..|:.|.
Human   599 ETMSVISVVTNCAL------------IGMSPQVNAVFPESKADLILIVVAVEHALLALKFILAFA 651

  Fly  1135 IPDVPSEVKTQMQREQLLAKEAKYQHGIK 1163
            |||.|..::.::.|.:..:.||..|..:|
Human   652 IPDKPRHIQMKLARLEFESLEALKQQQMK 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	15/53 (28%)
		Anoctamin	576..1149	CDD:461349	159/606 (26%)
ANO10	NP_001333393.1	Anoctamin	200..665	CDD:461349	159/605 (26%)