Protein Alignment CG6938 and ano1a

DIOPT Version :10

• Sequence 1: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Sequence 2: XP_068078314.1
• Gene: ano1a / 407698
• ZFINID: ZDB-GENE-121127-3
• Length: 986
• Species: Danio rerio
• Alignment Length: 1056
• Identity: 369/1056 - (34%)
• Similarity: 552/1056 - (52%)
• Gaps: 189/1056 - (17%)

  Fly   210 LPTHLEADSAEPSPTQAFGPKIVG-NNDEDIPG--TAMRRSLGLNLSPTLGSADRVNQSYEVMES 271
            |.|....:|.| ...|..|.|::| |:.|:.|.  .:|.|                |:.||
Zfish    27 LTTMTRLESGE-EQLQKAGEKLLGFNSTEEQPSGQESMWR----------------NEKYE---- 70

  Fly   272 SHSNVLPDQFGYRQLIPTERKA--SDTASSVSGSYYGSRKASKSNSLGGESGDERRVSKQDREGL 334
                          .:|.:.|.  .|.:.....|.|......||             .:.|.:..
Zfish    71 --------------SVPLDVKGIDEDNSKGTRDSLYPHTTLLKS-------------QQADEKPK 108

  Fly   335 DPESL-MFRDGRRKVDMVLAW---EEEDLGVMTE--------------------------AEAKR 369
            ||:.. .|:||.|::|.||.:   :.::.|..:.                          ::.:|
Zfish   109 DPKLWPYFKDGHRRIDYVLTYHIQKPQNTGKQSSKSCLGGCLCCKKRGQTNPPVPDPELASQEQR 173

  Fly   370 RD--------NRRSFMENLIKEGLEVELEDKSQSFNEKTFFLKIHLPWRLETRLAEVMNLKLPVK 426
            .|        .|..|.|||.:.|||:|.|:.::.  ....|||||.||.:..|.||.|.||:|..
Zfish   174 LDYHDDDQRLRREEFEENLREMGLEMEKEEGNKI--PGVGFLKIHAPWEVLCREAEFMKLKMPTI 236

  Fly   427 RFITISVKPSWDEENVVLRNMQYWKDVWQRLTKKIQ--LDQTLLEGETTFKAATANGNPEEQ--F 487
            :...:|     ...::|.:..::    .|:.|..:|  :....:|.|   |..:...:.|:|  |
Zfish   237 KKYEVS-----HGNSIVEKASRF----MQKFTAPLQPKVGDRQIEHE---KHLSYPFSREKQHLF 289

  Fly   488 IVKDRATAFTSAQRSLMVMQVLIRTPFDESDR-SGIRRLMNDGTYLGCFPLHEGRYDRPHSSGIS 551
            .:.||.:.|.|..||.:|.::|.||....:.. .||..|:.:|.|...:|||:|..|..|:. |:
Zfish   290 DLSDRNSFFDSKTRSSIVYEILKRTKCTRAKYIMGIISLLGNGIYTSAYPLHDGDIDDVHAE-IN 353

  Fly   552 LDRRVLYQTWAHPSQWYKKQPLCLVRKYFGDKIALYFCWLGFYTEMLVYPAVVGTLCFIYGLATL 616
             ||::||:.||..|.:||.||:.|:|||||:|:.|||.|||.||:||:..|:||.:.|:||.||:
Zfish   354 -DRKILYEEWASYSIFYKYQPIGLIRKYFGEKVGLYFAWLGVYTQMLIPAAIVGVIVFLYGCATV 417

  Fly   617 ESEDNTPSKEICNEYGTGNITLCPLCDKACSYQRLSESCLFSRLTYLFDNPSTVFFAIFMSFWAT 681
              :||.||.|||:|  ..|||:||:||:||||.:|..:|..:|.::||||.:||||||||:.||.
Zfish   418 --DDNIPSMEICDE--RNNITMCPMCDRACSYWKLVTACGTARASHLFDNAATVFFAIFMALWAA 478

  Fly   682 TFLELWKRKQSVLVWEWDLHNVDMDEENRP----EFETNATTFRMNPVTREKEP----------- 731
            .|:|.|||:|..|.:.|||...: |.|:.|    ||.....:.|     :||.|
Zfish   479 MFMEHWKRRQVRLNYLWDLTGFE-DTESHPRAEYEFHVMKKSLR-----KEKSPKAGNVKLTCTD 537

  Fly   732 ----YMSTWNRSIRFVITGSAVLFMISVVLSAVLGTILYRITLVSVIYGGGGFFVKEHAKLFTSV 792
                ||:       .:||   ::|:|.|.|:.|.|.:|||:::::.::.......:.:.:.....
Zfish   538 RMPAYMT-------IIIT---MIFLICVTLAIVFGVVLYRVSIMTALHMSSTPTFRSNIRATVKT 592

  Fly   793 TAALINLVVIMILTRIYHRMAIKLTNLENPRTHTEYEDSYTFKIFFFEFMNFYSSLIYIAFFKGR 857
            |.|:|||::|:|:..:|..:|..||.:|.|:|...:|:...||.|..:|.|.::.::|:|||:||
Zfish   593 TGAIINLIIIIIMDEVYGAVARWLTIMEVPKTDKSFEERLIFKTFVLKFANAFTPIVYLAFFRGR 657

  Fly   858 FFDYPGDDQARKSEF----FRLKNDICDPAGCLSELCIQLAIIMVGKQ-CWNNFMEYLFPKFWNW 917
            ....||     |..:    :|::.  |..||||.||||||.|.|:||| ..||..|...||....
Zfish   658 LIGRPG-----KYIYVMGSYRMEE--CAHAGCLMELCIQLCITMLGKQLIQNNLFEIGVPKIKKL 715

  Fly   918 WRQR----KHKQATKDESHLHMAWEQDYHMQDPGRLALFDEYLEMILQYGFVTLFVAAFPLAPLF 978
            .|||    ||::......|.|   |:| |...| .:.|..||:|||:|:|.||||||:|||||||
Zfish   716 LRQRKIDPKHQEELNKTLHRH---EKD-HFLGP-FVGLNPEYMEMIIQFGMVTLFVASFPLAPLF 775

  Fly   979 ALLNNVAEIRLDAYKMVTQARRPLAERVEDIGAWYGILRIITYTAVVSNAFVIAYTSDFIPRMVY 1043
            |||||:.||||||.|.||:.|||:|.|.:|||.||.:||.::..||:.|||||::|||||||:||
Zfish   776 ALLNNIIEIRLDAKKFVTELRRPIAVRAKDIGIWYTLLRGLSKVAVIVNAFVISFTSDFIPRLVY 840

  Fly  1044 KFVYSETHTLAGYIEHSLSIFNTSDYKEEWGASVSEK-----DPDTCQYRGYRNGPKDYEPYGLS 1103
            :::||...||.|::.|:||.||.:.::.  |....|.     ..|||:|:.||:.|....||..|
Zfish   841 QYMYSPDGTLHGFVNHTLSYFNVTHFQP--GTEPLEPMHLGYQVDTCRYKDYRDPPWSDTPYEFS 903

  Fly  1104 PHYWHVFAARLAFVVVFEHVVFVITGIMQFIIPDVPSEVKTQMQREQLLAKEAKYQHGIKRAQGD 1168
            ..:|.:.|||.|||::|::||.:::..:.::|||:|.::..::.:|:.|..|.    .:||.||.
Zfish   904 REFWAILAARFAFVILFQNVVMLMSDFVDWLIPDIPKDISLKIHKERNLIIEL----FMKREQGK 964

  Fly  1169 SQDIMSLFRDTSNRAS 1184
            .      :|:|.|..|
Zfish   965 K------YRNTMNDPS 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	77/274 (28%)
		Anoctamin	576..1149	CDD:461349	253/605 (42%)
ano1a	XP_068078314.1	Anoct_dimer	115..374	CDD:465044	77/274 (28%)
		Anoctamin	377..949	CDD:461349	253/605 (42%)