Protein Alignment CG6938 and Ano8

DIOPT Version :10

• Sequence 1: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Sequence 2: XP_017168360.1
• Gene: Ano8 / 382014
• MGIID: 2687327
• Length: 1212
• Species: Mus musculus
• Alignment Length: 1109
• Identity: 219/1109 - (19%)
• Similarity: 333/1109 - (30%)
• Gaps: 518/1109 - (46%)

  Fly   465 QTLLEG----------ETTFKAATANGNPEEQFI---VKDRATAFTSAQRSLMVM---------- 506
            ::||.|          :..|...|.:.:.||.||   |:.....|||.:|..::.
Mouse   116 ESLLRGADELGLRKAVKAEFGGGTRSFSCEEDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQ 180

  Fly   507 -QVLIRTPFDESDRSGIRRLMNDGTYLGCFPLHEGRYDRPHSSGISLDRRVLYQTWAHPSQWYKK 570
             :.|....|.| |:..|..|...|.....||:||.|.         |:|  |.::|....  .:.
Mouse   181 GEALHNVRFLE-DQPIIPELAARGIIQQVFPVHEQRI---------LNR--LMKSWVQAV--CEN 231

  Fly   571 QPLCLVRKYFGDKIALYFCWLGFYTEMLVYPAVVGTLCFIYGLATLESEDNTPSKEICNEYGTGN 635
            |||..:..|||.|||:||.||||||..:|||||.|::.:.:      :|.:..|:::
Mouse   232 QPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTF------TEADQTSRDV-------- 282

  Fly   636 ITLCPLCDKACSYQRLSESCLFSRLTYLFDNPSTVFFAIFMSFWATTFLELWKRKQSVLVWEWDL 700
                              ||              |.||:|...|:|.|||.|||:.:.|.::|.
Mouse   283 ------------------SC--------------VVFALFNVIWSTLFLEEWKRRGAELAYKWG- 314

  Fly   701 HNVDMD----EENRPEFETNATTFRMNPVTREKEPYMSTWNRSIRFVITGSAVLFMISVVLSAVL 761
             .:|..    ||.||:|.   ...|::|:||.:|.|...|.|          :||.:.|.|...|
Mouse   315 -TLDSPGEAVEEPRPQFR---GIRRISPITRAEEFYYPPWKR----------LLFQLLVSLPLCL 365

  Fly   762 GTILYRITLVSVIYGGGGFFVKEHAKLFTSVTAALINL---VVIMILTRI----YHRMAIKLTNL 819
            ..::....|:.      |.|..:...|.......|:..   |::.:|..:    |.::|:.|.::
Mouse   366 ACLICVFILML------GCFQLQELVLSVKGLPRLVRFLPKVMLALLVSVSAEGYKKLAVWLNDM 424

  Fly   820 ENPRTHTEYEDSYTFKIFFFEFMNFYSSLIYIAFF----------------KGRFFDYPGD---D 865
            ||.|..:.||.....|:..|:|:|.|.||.||.|:                :|:   :||.   |
Mouse   425 ENYRLESTYERHLIIKVVLFQFVNSYLSLFYIGFYLKDMDRLKEVRACAPSQGQ---HPGPLGMD 486

  Fly   866 QARKSE--------------FFRLKNDICDPAGCLSEL--------------------------- 889
            ..:.|.              |.||  .:|..:.|.|.|
Mouse   487 PCKGSRALQPLPPVLHPSLLFVRL--SMCPFSACRSPLPSVRPPVRLVPPQLLLLLSLTQSLERQ 549

  Fly   890 ----------------------------CIQLAIIMVGKQCWNNFMEYLFPKFW----------- 915
                                        ...||.:::.:|...|..|.|.|..:
Mouse   550 LQAVLVPLAALRFRLLLLSLRGLLLVARAKMLATLLITRQLLQNVREVLQPHLYRRLGSGELGLR 614

  Fly   916 -------------NWWR--QRKHKQATKDES---------------------------------- 931
                         |..|  .|:|.:|..||.
Mouse   615 TILELARALLGLLNPLRPDPRRHLEAQADEGGAGSRRCLGGGCGAPEEENEEEEEAAVERRPAGE 679

  Fly   932 ----------------------------------------------------------------- 931
                                                                             
Mouse   680 GGEVPEGPRGGKEEDEEEDDDEDEDEEYEGEEGSLLDCGLRLKKVSFAERGAGRRRPGPSPDGLL 744

  Fly   932 ----------------------------------------------------------------- 931
                                                                             
Mouse   745 EEGSPTMVEKGLEPGVFTLAEEDDEPEGPPGSPGPEPQTVLLRRARGEGRDQGPDGDRDTETGSG 809

  Fly   932 --------HLHMAW---EQDYHMQDPGRLAL----------FDEYLEMILQYGFVTLFVAAFPLA 975
                    |...:|   .::.|.....:..|          |.:|.||.:|:|:|.||.:|||||
Mouse   810 DAAGRQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLA 874

  Fly   976 PLFALLNNVAEIRLDAYKMVTQARRPLAERVEDIGAWYGILRIITYTAVVSNAFVIAYTSDFIPR 1040
            .|.||:||:.|||.||:|:.|..:||...|||.||.|..::..:...|:|.|.::|..
Mouse   875 ALCALVNNLIEIRSDAFKLCTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIGQ------- 932

  Fly  1041 MVYKFVYSETHTLAGYIEHSLSIFNTSDYKEEWGASVSEKDPDTCQYRGYRNGPKDYEPYGLSPH 1105
                         .|.::.   :|       .|                            |||.
Mouse   933 -------------CGQLQR---LF-------PW----------------------------LSPE 946

  Fly  1106 YWHVFAARLAFVVVFEHVVFVITGIMQFIIPDVPSEVKTQMQREQLLAKEAKYQHGIKRAQGDSQ 1170
                  |.:..|||.||:..::..::...|||:|..|..:|.:.:...:||     .||.:..:|
Mouse   947 ------AAIVSVVVLEHLALLVKYLIHVAIPDIPGWVAEEMAKLEYQRREA-----FKRHERQAQ 1000

  Fly  1171 DIMSLFRDTSNRASIAGSTVTTRGSWARRFSRLSDGLDAHVEVAARPRRSVESTVWEVSXHEEEA 1235
            .                     |....:|..|..:....|.|..||..|.        :...|||
Mouse  1001 Q---------------------RFQQQQRRRREEEERQRHAEQQARRERD--------TGGREEA 1036

  Fly  1236 ESEA 1239
            .:||
Mouse  1037 RAEA 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	31/131 (24%)
		Anoctamin	576..1149	CDD:461349	168/882 (19%)
Ano8	XP_017168360.1	Anoctamin	237..>443	CDD:461349	73/272 (27%)
		Anoctamin	<814..983	CDD:461349	60/232 (26%)
		PRK12323	<1031..>1210	CDD:481241	5/10 (50%)