Protein Alignment CG6938 and ANO5

DIOPT Version :10

• Sequence 1: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Sequence 2: NP_998764.1
• Gene: ANO5 / 203859
• HGNCID: 27337
• Length: 913
• Species: Homo sapiens
• Alignment Length: 882
• Identity: 361/882 - (40%)
• Similarity: 536/882 - (60%)
• Gaps: 65/882 - (7%)

  Fly   337 ESLMFRDGRRKVDMVLAWEEEDLGVMTEAEAKRRDNRRSFMENLIKEGLEVELEDKSQSFNEKTF 401
            :|:.||||.|::|.||::.::   |..:||.| .:.|:.|..||.|.|||:|:|||..|.:.:|:
Human    69 DSIFFRDGIRQIDFVLSYVDD---VKKDAELK-AERRKEFETNLRKTGLELEIEDKRDSEDGRTY 129

  Fly   402 FLKIHLPWRLETRLAEVMNLKLPVKRFITISVKPSWDEENVVLRNMQYWKDVWQRLTKKIQLDQT 466
            |:|||.||.:....|||:.:|:|:|.  :...:|.....:.||              ..::|..:
Human   130 FVKIHAPWEVLVTYAEVLGIKMPIKE--SDIPRPKHTPISYVL--------------GPVRLPLS 178

  Fly   467 LLEGETTFKAATANGNPEEQFIVKDRATAFTSAQRSLMVMQVLIRTPF---DESDRSGIRRLMND 528
            :......:..|..:.:.:|.|:::|:||.|.|:.|:.:|..:|.|.||   |...|.||.||:|.
Human   179 VKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYILSRCPFGIEDGKKRFGIERLLNS 243

  Fly   529 GTYLGCFPLHEGRYDRP-HSSGISLDRRVLYQTWAHPSQWYKKQPLCLVRKYFGDKIALYFCWLG 592
            .||...:|||:|:|.:| .....:.:|..|:|.||..|.:||:|||.|::.|:|:||.:||.:||
Human   244 NTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQPLDLIKNYYGEKIGIYFVFLG 308

  Fly   593 FYTEMLVYPAVVGTLCFIYGLATLESEDNTPSKEICNEYGTGNITLCPLCDKACSYQRLSESCLF 657
            ||||||.:.||||..||||||  |..|.||.|.|||:....|.:.:|||||:.|.|.||:.:||.
Human   309 FYTEMLFFAAVVGLACFIYGL--LSMEHNTSSTEICDPEIGGQMIMCPLCDQVCDYWRLNSTCLA 371

  Fly   658 SRLTYLFDNPSTVFFAIFMSFWATTFLELWKRKQSVLVWEWDLHNVDMDEEN-----RPEFETNA 717
            |:.::||||.|||||||||..|.|.|||.||::|:.|.:||||  ||.:||.     |||||...
Human   372 SKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDL--VDFEEEQQQLQLRPEFEAMC 434

  Fly   718 TTFRMNPVTREKEPYMSTWNRSIRFVITGSAVLFMISVVLSAVLGTILYRITLVSVIYGGGGFFV 782
            ...::|.||:|.||||..:.|...:.::|:.|...:|:|:::::..|:||::    ::.....|:
Human   435 KHRKLNAVTKEMEPYMPLYTRIPWYFLSGATVTLWMSLVVTSMVAVIVYRLS----VFATFASFM 495

  Fly   783 KEHAKL-----------FTSVTAALINLVVIMILTRIYHRMAIKLTNLENPRTHTEYEDSYTFKI 836
            :..|.|           .||:|.:.:|.:||:||...|.:::..:|.:|.|||:.|||.|.|.|:
Human   496 ESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYEKISAWITKMEIPRTYQEYESSLTLKM 560

  Fly   837 FFFEFMNFYSSLIYIAFFKGRFFDYPGDDQARKSEFFRLKNDICDPAGCLSELCIQLAIIMVGKQ 901
            |.|:|:|||||..|:|||||:|..|||......:|:   :::.|||.|||.||..||.|||.|||
Human   561 FLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNEW---RSEECDPGGCLIELTTQLTIIMTGKQ 622

  Fly   902 CWNNFMEYLFPKFWNWWRQRKHKQATKDESHLHMAWEQDYHMQDPGRLALFDEYLEMILQYGFVT 966
            .:.|..|.::|...||||:||   |..:...|:..||||:.::..|.|.||.||||.:.|:||||
Human   623 IFGNIKEAIYPLALNWWRRRK---ARTNSEKLYSRWEQDHDLESFGPLGLFYEYLETVTQFGFVT 684

  Fly   967 LFVAAFPLAPLFALLNNVAEIRLDAYKMVTQARRPLAERVEDIGAWYGILRIITYTAVVSNAFVI 1031
            ||||:||||||.||:||:.|||:||:|:.||.||.:|.:...||.|..||..:...:|.:|||::
Human   685 LFVASFPLAPLLALINNIVEIRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIV 749

  Fly  1032 AYTSDFIPRMVYKFVYS--ETHTLAGYIEHSLSIFNTSDYKEEWGASVSEKDPDTCQYRGYRNGP 1094
            |:|||.|||:||.:.||  .|..:.||:.:|||:|..:|:......| .::|..||:||.||..|
Human   750 AFTSDIIPRLVYYYAYSTNATQPMTGYVNNSLSVFLIADFPNHTAPS-EKRDFITCRYRDYRYPP 813

  Fly  1095 KDYEPYGLSPHYWHVFAARLAFVVVFEHVVFVITGIMQFIIPDVPSEVKTQMQREQLLAKEAKYQ 1159
            .|...|..:..:|||.||::.|::|.|||||::..::.::|||||.:|..:::||:|:.  .|..
Human   814 DDENKYFHNMQFWHVLAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMT--IKIL 876

  Fly  1160 HG-----IKRAQG-DSQDIMSLFRDTSNRASIAGSTV 1190
            |.     :|...| :|.:.........|:|.:|.||:
Human   877 HDFELNKLKENLGINSNEFAKHVMIEENKAQLAKSTL 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	80/236 (34%)
		Anoctamin	576..1149	CDD:461349	264/590 (45%)
ANO5	NP_998764.1	Anoct_dimer	72..289	CDD:465044	80/236 (34%)
		Anoctamin	292..868	CDD:461349	264/590 (45%)
		COG5594	<462..>583	CDD:227881	44/124 (35%)