Protein Alignment CG6938 and ANO6

DIOPT Version :10

• Sequence 1: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Sequence 2: NP_001191732.1
• Gene: ANO6 / 196527
• HGNCID: 25240
• Length: 931
• Species: Homo sapiens
• Alignment Length: 965
• Identity: 364/965 - (37%)
• Similarity: 545/965 - (56%)
• Gaps: 139/965 - (14%)

  Fly   239 IPGTAMRRSLGLNLSPTLGSADRVNQSYEVMESSHSNVLPDQFGYRQLIPTERKASDTASSVSGS 303
            :|.:.:..:||..:.|.|||          :||.|
Human    40 LPSSLVLENLGQTIVPDLGS----------LESQH------------------------------ 64

  Fly   304 YYGSRKASKSNSLGGESGDERRVSKQDREGLDPESLMFRDGRRKVDMVLAWEEEDLGVMTE--AE 366
                              |.|....::..| .|:||.|.||:|::|.||.:|:|......:  ..
Human    65 ------------------DFRTPEFEEFNG-KPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTN 110

  Fly   367 AKRRDNRRSFMENLIKEGLEVELEDKSQSFNEKTFFLKIHLPWRLETRLAEVMNLKLPVKRFITI 431
            .|:|..|:::..|||..||  :||......::|..|:|:|.||.:....||:|::|||
Human   111 EKQRRKRQAYESNLICHGL--QLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLP------- 166

  Fly   432 SVKPSWDEENVVLRNMQYWKDVWQRLTKKIQLDQTLLEGETTFKAATANGNPEEQFIVKDRATAF 496
             :||: |.:|   |:..:....|  .||.:.:|:::::.|..|..|....|....|.:.||...|
Human   167 -LKPN-DLKN---RSSAFGTLNW--FTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFF 224

  Fly   497 TSAQRSLMVMQVLIRTPF---DESDRSGIRRLMNDGTYLGCFPLHEGRYDR-PHSSGISLDRRVL 557
            ..|.||.:|..:|.|..:   :...:.||.||:|.|.|...||||:.::.| ........:|.:|
Human   225 NPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLL 289

  Fly   558 YQTWAHPSQWYKKQPLCLVRKYFGDKIALYFCWLGFYTEMLVYPAVVGTLCFIYGLATLESEDNT 622
            |:.||||...||||||.|:|||:|:||.:||.|||:||:||:..||||..||:||.  |..::.|
Human   290 YREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGY--LNQDNCT 352

  Fly   623 PSKEICNEYGTGNITLCPLCDKACSYQRLSESCLFSRLTYLFDNPSTVFFAIFMSFWATTFLELW 687
            .|||:|:....|.|.:||.||:.|.:.:|:.:|..|:...:||:..|:.||:||..|.|.|||.|
Human   353 WSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFW 417

  Fly   688 KRKQSVLVWEWDLHNVDMDEENRPEFETNATTFRMNPVTREKE--PYMSTWNRSIRFVITGSAVL 750
            ||:|:.|.:|||...:..:|:.|||:|...|...:|.:|:|:|  |: :.|.:.||..:..|||.
Human   418 KRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPF-TAWGKCIRITLCASAVF 481

  Fly   751 FMISVVLSAVLGTILYRITLVSVIYGGGGFFVKEHAKL------------------FTSVTAALI 797
            |.|.:::::|:|.|:||:::          |:...|||                  .||:||::|
Human   482 FWILLIIASVIGIIVYRLSV----------FIVFSAKLPKNINGTDPIQKYLTPQTATSITASII 536

  Fly   798 NLVVIMILTRIYHRMAIKLTNLENPRTHTEYEDSYTFKIFFFEFMNFYSSLIYIAFFKGRFFDYP 862
            :.::||||..||.::||.:||.|.|||.|:||:|.|.|:|.|:|:|:|||..|||||||:|..||
Human   537 SFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYP 601

  Fly   863 GDDQARKSEFFRLKNDICDPAGCLSELCIQLAIIMVGKQCWNNFMEYLFPKFWNWWRQRKHKQAT 927
            ||......::   :|:.|||.|||.||..||.|||.||..|||..|.|.|...| ...|.|:.:.
Human   602 GDPVYWLGKY---RNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMN-LIGRFHRVSG 662

  Fly   928 KDESHLHMAWEQDYHMQDPGRLALFDEYLEMILQYGFVTLFVAAFPLAPLFALLNNVAEIRLDAY 992
            .::  :...||||||:|..|:|.||.||||||:|:||||||||:||||||.||:||:.|||:||:
Human   663 SEK--ITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAW 725

  Fly   993 KMVTQARRPLAERVEDIGAWYGILRIITYTAVVSNAFVIAYTSDFIPRMVYKFVYS-------ET 1050
            |:.||.||.:.|:.:|||||..|::.|...|||:||.:||:|||.|||:||.:.:|       .:
Human   726 KLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTS 790

  Fly  1051 HTLAGYIEHSLSIFNTSDYKEEWGASVSEKDP-------DTCQYRGYRNGPKDYEPYGLSPHYWH 1108
            :|:.|||.::||||..:|:|.:     |:.:|       .||:||.:|..|...:.|..:.:|||
Human   791 YTMEGYINNTLSIFKVADFKNK-----SKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWH 850

  Fly  1109 VFAARLAFVVVFEHVVFVITGIMQFIIPDVPSEVKTQMQREQLLAKEAKYQHGIK 1163
            |.||:|||::|.|||::.:...:.:.||||....|:::|||:.|.::..:::.:|
Human   851 VIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLK 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	77/238 (32%)
		Anoctamin	576..1149	CDD:461349	264/606 (44%)
ANO6	NP_001191732.1	Anoct_dimer	82..305	CDD:465044	77/238 (32%)
		Anoctamin	308..891	CDD:461349	264/606 (44%)