Protein Alignment CG6938 and ANO4

DIOPT Version :10

• Sequence 1: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Sequence 2: XP_011536213.2
• Gene: ANO4 / 121601
• HGNCID: 23837
• Length: 1152
• Species: Homo sapiens
• Alignment Length: 1123
• Identity: 422/1123 - (37%)
• Similarity: 621/1123 - (55%)
• Gaps: 151/1123 - (13%)

  Fly   125 IDSDLQPRHVESDPIDSVY--------------SCQASHNVPVDSPSKPATPIPPKSKLS---AS 172
            :.||| |..|..|....||              ||.||.::         ||:|..|..|   .|
Human    92 LPSDL-PLFVSKDAGIPVYHRSFTRKTDQATPLSCPASLSI---------TPVPSYSSSSQETLS 146

  Fly   173 RARAG---SAAYTEKWLNSSVMRTSNGNPLFPKSNAIAR--PLP-----THLEADSA--EPSPTQ 225
            :...|   |....||.|.....|:....|...:...:.|  .||     ..:||.|:  ....|:
Human   147 QDTTGLSLSIHGAEKRLQIHQRRSVASRPASRRRLPVVRHSSLPPGRRSIKMEASSSGITNGKTK 211

  Fly   226 AFGPKIVGNNDEDIPGTAMRRSLGLNLSPTLGSADRVNQSYEVMESSHS-----NVLPDQFGYRQ 285
            .|.|:    ...|:.|    ..|.:.:.|. |....|:.| |::.:...     |:|.|:.   :
Human   212 VFHPE----GGVDLQG----YQLDMQILPD-GPKSDVDFS-EILNAIQEMAKDVNILFDEL---E 263

  Fly   286 LIPTERKASDTASSVSGSYYGSRKASKSNSLGGESGDERRVSKQDREGLDPESLMFRDGRRKVDM 350
            .:.:..|..|:..........|..||:..: |||:..||..|         ..|.||||:.::|.
Human   264 AVSSPCKDDDSLLHPGNLTSTSDDASRLEA-GGETVPERNKS---------NGLYFRDGKCRIDY 318

  Fly   351 VLAWEEEDLGVMTEAEAKRRDNRRSFMENLIKEGLEVELEDKSQSFNEKTFFLKIHLPWRLETRL 415
            :|.:.:.:         .:.:.|..|..|:..|||::|.|  |...|....|:|:|.||.:..|.
Human   319 ILVYRKSN---------PQTEKREVFERNIRAEGLQMEKE--SSLINSDIIFVKLHAPWEVLGRY 372

  Fly   416 AEVMNLKLPVKRFITISVKPSWDEENVVLRNMQYWKDVWQRLT--------KKIQLD-QTL--LE 469
            ||.||:::|.:|.|           ..:.|..::...:.::::        |.::|| :||  ||
Human   373 AEQMNVRMPFRRKI-----------YYLPRRYKFMSRIDKQISRFRRWLPKKPMRLDKETLPDLE 426

  Fly   470 GETTFKAATANGNPEEQ-----FIVKDRATAFTSAQRSLMVMQVLIRTPFDE-SDRSGIRRLMND 528
            ....:.|      |..|     ||:.::.|.|.:|.||.:|..:|.|..::| .::.|:.||:.:
Human   427 ENDCYTA------PFSQQRIHHFIIHNKETFFNNATRSRIVHHILQRIKYEEGKNKIGLNRLLTN 485

  Fly   529 GTYLGCFPLHEGRYDRPHS---SGISLDRRVLYQTWAHPSQWYKKQPLCLVRKYFGDKIALYFCW 590
            |:|...||||||.|...:|   .|....|.:||:.||....|||.|||.|||:|||:||.|||.|
Human   486 GSYEAAFPLHEGSYRSKNSIRTHGAENHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAW 550

  Fly   591 LGFYTEMLVYPAVVGTLCFIYGLATLESEDNTPSKEICNEYGTGNITLCPLCDKACSYQRLSESC 655
            ||:||.||...|.:|...|:||:.||  :.:..|||:|.   ..:|.:||:|||.|.:.|||:||
Human   551 LGWYTGMLFPAAFIGLFVFLYGVTTL--DHSQVSKEVCQ---ATDIIMCPVCDKYCPFMRLSDSC 610

  Fly   656 LFSRLTYLFDNPSTVFFAIFMSFWATTFLELWKRKQSVLVWEWDLHNVDMDEEN---RPEFETN- 716
            :::::|:||||.:|||||:||:.|||.|||.|||:::|:.::|||  :|.:||.   ||:||..
Human   611 VYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDL--IDWEEEEEEIRPQFEAKY 673

  Fly   717 ATTFRMNPVTREKEPYMSTWNRSIRFVITGSAVLFMISVVLSAVLGTILYRITLVSVIYGGGGFF 781
            :...||||::.:.|||.:..::..|.:::.|.:.|||.||::||.|.::||:..||.........
Human   674 SKKERMNPISGKPEPYQAFTDKCSRLIVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWAL 738

  Fly   782 VKEHAKLFTSVTAALINLVVIMILTRIYHRMAIKLTNLENPRTHTEYEDSYTFKIFFFEFMNFYS 846
            ::.::::.|:.||..||..:||:|..:|.::|:.|||||.|||.:|:|:|:|.|:|.|:|:|..|
Human   739 IRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNS 803

  Fly   847 SLIYIAFFKGRFFDYPGDDQARKSEFFRLKN----DICDPAGCLSELCIQLAIIMVGKQCWNNFM 907
            |..|||||.|||..:||       .:.||.|    :.|.|:|||.:||:|:.||||.||.|||||
Human   804 STFYIAFFLGRFTGHPG-------AYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFM 861

  Fly   908 EYLFPKFWNWWRQRKHKQATKDESHLHM-AWEQDYHMQDPGRLALFDEYLEMILQYGFVTLFVAA 971
            |..:|...|||.:||.:|....|..:.. .||:||::|......|||||||||||:||.|:||||
Human   862 ELGYPLIQNWWTRRKVRQEHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAA 926

  Fly   972 FPLAPLFALLNNVAEIRLDAYKMVTQARRPLAERVEDIGAWYGILRIITYTAVVSNAFVIAYTSD 1036
            ||||||.|||||:.||||||||.|||.|||||.|.:|||.|||||..|...:|::||||||.|||
Human   927 FPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSD 991

  Fly  1037 FIPRMVYKFVY--------SETHTLAGYIEHSLSIFNTSDYK-----EEWGASVSEKDPDTCQYR 1088
            ||||:||.:.|        :....:.||:..|||:|..||::     |..|:..|......|:||
Human   992 FIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYR 1056

  Fly  1089 GYRNGPKDYEPYGLSPHYWHVFAARLAFVVVFEHVVFVITGIMQFIIPDVPSEVKTQMQREQLLA 1153
            .||:.|....|||.:..:|||.||||||::||||:||.|..::.::|||:|.:::.:|:||:.|.
Human  1057 DYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLI 1121

  Fly  1154 KEAKYQHGIKRAQGDSQD 1171
            :|..|:..::|.|.:.::
Human  1122 QEMMYEAELERLQKERKE 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	74/252 (29%)
		Anoctamin	576..1149	CDD:461349	281/594 (47%)
ANO4	XP_011536213.2	Anoct_dimer	308..533	CDD:465044	74/252 (29%)
		Anoctamin	536..1117	CDD:461349	281/594 (47%)