Protein Alignment CG6938 and ano5a

DIOPT Version :10

• Sequence 1: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Sequence 2: XP_021326432.1
• Gene: ano5a / 100534737
• ZFINID: ZDB-GENE-091013-2
• Length: 931
• Species: Danio rerio
• Alignment Length: 906
• Identity: 385/906 - (42%)
• Similarity: 564/906 - (62%)
• Gaps: 87/906 - (9%)

  Fly   327 SKQDREGLDPESLMFRDGRRKVDMVLAWEEEDLGVMTEAEAKRRDNRRSFMENLIKEGLEVELED 391
            |:.|::....:|:.||||.|::|.||::.::..|      .|::|.|:.|..||.|.|||||.||
Zfish    58 SRVDKQQQSKDSVYFRDGVRRIDFVLSYIDDKDG------EKKQDRRKVFEANLQKAGLEVETED 116

  Fly   392 KSQSFNEKTFFLKIHLPWRLETRLAEVMNLKLPVKRFITISVKPSWDEENVVLRNMQYWKDV--- 453
            ||:|.:.||:|||||:||.:....|:|:.:|:|.|             .|.:..|    |::
Zfish   117 KSESEDGKTYFLKIHVPWEVLATYADVLKIKVPFK-------------ANDIPEN----KEIPMG 164

  Fly   454 WQRLTKKIQLDQTLLEGETTFKAATANGNPEEQFIVKDRATAFTSAQRSLMVMQVLIRTPF--DE 516
            |  |....:|...::..|..|..:|.:.:..:.|:::|:.|.|.::.|:.:|..:|.|.|:  ::
Zfish   165 W--LFTPFRLPDHVMNPEPDFFTSTFDKSKIDFFLIEDKETLFPASTRNRIVYYLLSRIPYSTED 227

  Fly   517 SDRSGIRRLMNDGTYLGCFPLHEGRY-DRPHSSGISLDRRVLYQTWAHPSQWYKKQPLCLVRKYF 580
            .|:.||:||:|:|||...||||:.|| .|........:|..||:.||..|.:||:|||.|:|||:
Zfish   228 KDKKGIKRLLNNGTYTSAFPLHDCRYWTRSRDDNCESERYSLYKNWARFSSFYKEQPLNLIRKYY 292

  Fly   581 GDKIALYFCWLGFYTEMLVYPAVVGTLCFIYGLATLESEDNTPSKEICNEYGTGNITLCPLCDKA 645
            |:||.:||.|||||||||.|.||||.||||||:||.  ::|..|:|||||...|.|.:||||||.
Zfish   293 GEKIGIYFAWLGFYTEMLSYAAVVGLLCFIYGVATF--DENIWSREICNETIGGQIVMCPLCDKK 355

  Fly   646 CSYQRLSESCLFSRLTYLFDNPSTVFFAIFMSFWATTFLELWKRKQSVLVWEWDLHNVDMDEEN- 709
            |.|.:||.:|..|..:|||||.:||||||||..|.|.|||.|||:|:.|.:||||  ||.:||.
Zfish   356 CGYWKLSTTCSSSWQSYLFDNAATVFFAIFMGIWVTLFLEFWKRRQARLEYEWDL--VDFEEEQQ 418

  Fly   710 ----RPEFETNATTFRMNPVTREKEPYMSTW-------NRSIRFVITGSAVLFMISVVLSAVLGT 763
                |||:|:..|..|:|.||:|:|     |       :::.|||:..:.||..||:::::::|.
Zfish   419 QLQLRPEYESKCTNRRLNRVTQEQE-----WVLDQTPADKAGRFVLCWTTVLLWISLIIASIIGV 478

  Fly   764 ILYRITL----VSVIYGG--------GGFFVKEHAKLFTSVTAALINLVVIMILTRIYHRMAIKL 816
            |.||:.:    .|::...        |.....:.|   |||||:.||.|:||:|..:|.|:|||:
Zfish   479 IAYRLAVFAAFASIMKDSPTNKLEIVGNLITPQFA---TSVTASCINFVIIMVLNFLYERVAIKI 540

  Fly   817 TNLENPRTHTEYEDSYTFKIFFFEFMNFYSSLIYIAFFKGRFFDYPGDDQARKSEFFRLKNDICD 881
            |::|.|:||.|||:..|.|:|.|:|:|:|||..|:|||||:|..|||:.......:..|:|:.|:
Zfish   541 TDMEVPKTHVEYENKLTIKMFLFQFVNYYSSCFYVAFFKGKFVGYPGNYAYMFGPWSGLRNEECE 605

  Fly   882 PAGCLSELCIQLAIIMVGKQCWNNFMEYLFPKFWNWWRQRKHKQATKDESHLHMAWEQDYHMQDP 946
            |.|||.||..||.|:|||||.|.|..|.|.|...|||..|   .|......|:..||||:.:|:.
Zfish   606 PGGCLIELTTQLVIVMVGKQVWGNIQEALVPWLRNWWVSR---SARNHPESLYSRWEQDHDLQNL 667

  Fly   947 GRLALFDEYLEMILQYGFVTLFVAAFPLAPLFALLNNVAEIRLDAYKMVTQARRPLAERVEDIGA 1011
            |:|.||.|||||::|:||:|||||:||||||.||:||:.|:|:||:|..||.|||:|.:...|||
Zfish   668 GQLGLFYEYLEMVIQFGFITLFVASFPLAPLLALMNNILEVRVDAWKFTTQFRRPVAAKAHSIGA 732

  Fly  1012 WYGILRIITYTAVVSNAFVIAYTSDFIPRMVYKFVYS--ETHTLAGYIEHSLSIFNTSDYKEEWG 1074
            |..||.:|...:||:|||::::|||.|||:||::|::  ...:::|||.|||||:|.|::..| .
Zfish   733 WEEILNMIAVFSVVTNAFIVSFTSDMIPRLVYQYVHNTGNAASMSGYITHSLSIYNISEFPPE-N 796

  Fly  1075 ASVSEKDPD--------TCQYRGYRNGPKDYEPYGLSPHYWHVFAARLAFVVVFEHVVFVITGIM 1131
            ....:::||        ||:||.||..|...:.|..:..:||:.||:|||:::.||||||:...:
Zfish   797 RPDDDENPDWFNAGNYTTCRYRDYRYPPGHEKQYTHNMDFWHILAAKLAFIIIMEHVVFVVKFFV 861

  Fly  1132 QFIIPDVPSEVKTQMQREQLLAKEAKYQHGIKRAQGDSQDIMSLFRDTSNRASIAGSTVTT 1192
            .::||||||:||.:::||:.|.:|..:.:.:::.:..    :||..|..|  .|...|..|
Zfish   862 AWLIPDVPSDVKARVKRERYLIQEYLHDYEVEKLKNQ----LSLNTDVHN--DITACTCPT 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	83/238 (35%)
		Anoctamin	576..1149	CDD:461349	285/606 (47%)
ano5a	XP_021326432.1	Anoct_dimer	71..285	CDD:465044	83/238 (35%)
		Anoctamin	288..879	CDD:461349	285/606 (47%)