Protein Alignment CG6938 and ano2

DIOPT Version :10

• Sequence 1: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Sequence 2: XP_017948300.2
• Gene: ano2 / 100492483
• XenbaseID: XB-GENE-981445
• Length: 1089
• Species: Xenopus tropicalis
• Alignment Length: 1132
• Identity: 387/1132 - (34%)
• Similarity: 600/1132 - (53%)
• Gaps: 137/1132 - (12%)

  Fly   138 PIDSVYSCQASH--NVPVDSPSKPATPIPPKSKLSASRARAGSAAYTEKWLNSSVMRTSNGNPLF 200
            ||.::.|..:|.  ...:::|..|||.||    |:.:.|:           |..:.||:..:...
 Frog    30 PISTLVSTSSSQISLCKMEAPQAPATDIP----LTVNAAQ-----------NGHIQRTTGESCPP 79

  Fly   201 PKSN--AIARPLPTHLEADSAEPSPTQAFGPKI--------VGNNDEDIPGTAMRRSLGLNLSPT 255
            ||:.  .:.:.||   ||.|.:.:...||....        |.||..|  |....:..|::....
 Frog    80 PKTKYLTVTQYLP---EAYSHQGNVNGAFDASTCPDAHIYSVVNNYVD--GNQQTKPSGMHFGDG 139

  Fly   256 LGSADRVNQSYEVMESSHSNVLPDQFGYR---------QLIPTERKASDTASSVSGS--YYGSRK 309
            ....|.|...:....|||.|..|.  .:|         ..|..|........|:.|.  :.|::|
 Frog   140 KRKVDYVLAYHYRYRSSHHNGSPG--SHRPPAVIVSNGNSITPEEVGKTPQQSLPGDLHHQGNQK 202

  Fly   310 ASKSNSLGGESGDERRVSKQDREGLDPESLMFRDGRRKVDMVLAWEEEDLGVMTEAEAKRRDNRR 374
            .:..|.....:.|... |:...:...|:.:          :|:.....|     ..|.:::..|.
 Frog   203 KNIHNHQKHNNSDHSH-SENGNQPHHPDGV----------VVVEINHHD-----ALEEEKKIQRE 251

  Fly   375 SFMENLIKEGLEVEL--EDKSQSFNEKTFFLKIHLPWRLETRLAEVMNLKLPVKRFITISVKPSW 437
            .|.:||::.|||:|.  |.|||..|    |::||.||.:.:|.||.:.:|:|.|:...:.
 Frog   252 EFEQNLMEAGLELEKDPETKSQGLN----FVRIHAPWPVLSREAEFLKIKVPTKKMYEVK----- 307

  Fly   438 DEENVVLRNMQYWKDVWQRLTKKIQLDQTLLEGETTFKAATANGNPEEQFI--VKDRATAFTSAQ 500
             ::..:|:.:.   .:|.:.||.:|............|..:...:.::..:  :||:.|.|.:|.
 Frog   308 -QDTGILKKLY---SLWNKCTKILQPKVPQFSENAKMKHLSYPFSRDKMHLYDIKDKDTFFDNAT 368

  Fly   501 RSLMVMQVLIRTPFDESDRS-GIRRLMNDGTYLGCFPLHEGRYDRPHSSGISLDRRVLYQTWAHP 564
            ||.:|.::|.||...::..| ||..|:.:..|...:|||:|.||  |:...:.:|.:|::.||..
 Frog   369 RSRIVHEILKRTSSVKAKYSMGITTLIANNVYDSAYPLHDGDYD--HNKNETNERMLLHREWARY 431

  Fly   565 SQWYKKQPLCLVRKYFGDKIALYFCWLGFYTEMLVYPAVVGTLCFIYGLATLESEDNTPSKEICN 629
            ..:||.||:.|:|||||:||.|||.|||.||.:|:..::||.:.|:||.||::::  .||:|:|:
 Frog   432 GAFYKYQPVDLIRKYFGEKIGLYFAWLGLYTWLLIPASLVGIIVFLYGCATIDAD--IPSQEMCD 494

  Fly   630 -EYGTGNITLCPLCDKACSYQRLSESCLFSRLTYLFDNPSTVFFAIFMSFWATTFLELWKRKQSV 693
             |.|   ..:||||||||.:.:||.:|..:|.::|||||:||||::||:.|||.|||.|||.|..
 Frog   495 QEQG---FVMCPLCDKACDFWKLSSACGTARASHLFDNPATVFFSVFMALWATLFLEYWKRLQMR 556

  Fly   694 LVWEWDLHNVDMDEEN-----RPEFETNATTFR-------MNPVTREKEPYMSTW-NRSIRFVIT 745
            |.:.|||..::.:||.     |||:||.....:       .|...:||    .|| :|...:::.
 Frog   557 LSYFWDLTGLEEEEERIKEHPRPEYETKLLLMKEKSKGNGKNGNKKEK----LTWRDRIPAYLVN 617

  Fly   746 GSAVLFMISVVLSAVLGTILYRITLVSVIYGGGGFFVKEHAKLFTSVTAALINLVVIMILTRIYH 810
            .||:||||::..|||.|.|:||||..:.:........:.:.::..:.||.:||||||:||..||.
 Frog   618 FSAILFMIALTFSAVFGVIIYRITTAAALAVSTSEVTRSNVRVTVTATAVIINLVVILILDEIYG 682

  Fly   811 RMAIKLTNLENPRTHTEYEDSYTFKIFFFEFMNFYSSLIYIAFFKGRFFDYPGDDQARKSEFFRL 875
            .:|..||.:|.|:|...:|:....|.|..:|:|.|:|:.|:|||||||...|| ..|.....:|:
 Frog   683 SVAKWLTEIEVPKTEKTFEERLILKAFLLKFVNSYASIFYVAFFKGRFTGRPG-SYAYIFHGYRM 746

  Fly   876 KNDICDPAGCLSELCIQLAIIMVGKQ-CWNNFMEYLFPKFWNWWRQRKHKQATKDESHLH----- 934
            :.  |.|.|||.||||||:|||:||| ..||..|...|||...:|:.|.::|...|::|:
 Frog   747 EE--CAPGGCLIELCIQLSIIMLGKQLIQNNLFEIAIPKFKKLYRKFKDERAEPGENNLNNTKEP 809

  Fly   935 MAWEQDYHMQDPGRLALFDEYLEMILQYGFVTLFVAAFPLAPLFALLNNVAEIRLDAYKMVTQAR 999
            ..|.:||.::.  ...|..||:|||:|:||||||||:||||||||||||:.|:||||.|.||:.|
 Frog   810 QQWVRDYALEP--FTGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEVRLDAKKFVTELR 872

  Fly  1000 RPLAERVEDIGAWYGILRIITYTAVVSNAFVIAYTSDFIPRMVYKFVYSETHTLAGYIEHSLSIF 1064
            ||.|.|.:|||.||.||..|...:|:.|||||:.|||||||:||:::|||..|:.|::.|:||.|
 Frog   873 RPDAVRAKDIGIWYNILSGIGKFSVIINAFVISVTSDFIPRLVYQYMYSENGTMHGFLNHTLSYF 937

  Fly  1065 NTSDYKEEWGASVSE--KDPDTCQYRGYRNGPKDYEPYGLSPHYWHVFAARLAFVVVFEHVVFVI 1127
            |.|..|.......|:  ::.:.|:|:.||..|.....|..|..||.:.|.|||||::|:::|..:
 Frog   938 NVSHLKPGTQPENSQFAQNVEICRYKDYREPPSSPNQYDFSKQYWTILAVRLAFVILFQNLVMFL 1002

  Fly  1128 TGIMQFIIPDVPSEVKTQMQREQ------LLAKEAK--------YQHGIKRAQGDSQDIMSLFRD 1178
            :.::.::|||:|.::..|:::|:      .|.:|.|        ..|..:|::.:::.      .
 Frog  1003 SAVVDWLIPDIPKDISEQIKKEKTMLVNVFLKEEHKKLQLLENFLMHDKQRSKSENRG------Q 1061

  Fly  1179 TSNRASIAGSTVTTRGSWARRFSRLSD 1205
            .|..||....:.:.|||:....|..:|
 Frog  1062 RSRAASFCQFSRSQRGSFTSFSSHHTD 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	63/237 (27%)
		Anoctamin	576..1149	CDD:461349	260/594 (44%)
ano2	XP_017948300.2	Anoct_dimer	135..440	CDD:465044	81/337 (24%)
		Anoctamin	443..1024	CDD:461349	260/594 (44%)