Protein Alignment CG6938 and Ano2

DIOPT Version :10

• Sequence 1: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Sequence 2: XP_017448527.2
• Gene: Ano2 / 100361584
• RGDID: 1591606
• Length: 975
• Species: Rattus norvegicus
• Alignment Length: 998
• Identity: 363/998 - (36%)
• Similarity: 539/998 - (54%)
• Gaps: 141/998 - (14%)

  Fly   277 LPDQFGYRQLIPTE--RKASDTASSVSGSYYGSRKASKSNSLGGESGDERRVSKQDREGLDPESL 339
            ||.|.....|.|::  |:.|....||..:|..:.:.:.|         |.|:|:          :
  Rat    22 LPGQRDNSSLHPSQVSRRESSRDRSVINNYLDANEPASS---------EARLSR----------M 67

  Fly   340 MFRDGRRKVDMVLAWE-----------------------------------EEDLGVMTEAEAKR 369
            .|.|.:||||.|||:.                                   :.:||.:...|.:|
  Rat    68 HFHDNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDIELGPLDALEEER 132

  Fly   370 RDNRRSFMENLIKEGLEVE--LEDKSQSFNEKTFFLKIHLPWRLETRLAEVMNLKLPVKRFITIS 432
            |:.|..|..||:..|||:|  ||.|||.    :.|::||.||::..|.||.:.:|:|.|:...|.
  Rat   133 REQRDEFEHNLMAAGLELEKDLESKSQG----SVFVRIHAPWQVLAREAEFLKIKVPTKKMYEIK 193

  Fly   433 VKPSWDEENVVLRNMQYWKDVWQRLTKKIQLDQTLLEGETTFKAATANGNPEEQFI--VKDRATA 495
            ...|..::         :..:.|.|:..:| .:.........|..:...:.|:.::  ::::...
  Rat   194 AGGSIAKK---------FSAILQTLSSPLQ-PRVPEHSNNRMKNLSYPFSREKMYLYNIQEKDAF 248

  Fly   496 FTSAQRSLMVMQVLIRTPFDESDRS-GIRRLMNDGTYLGCFPLHEGRYDRPHSSGISL-DRRVLY 558
            |.:|.||.:|.::|.||....::.: ||..|:.:..|...:|||:|.||.|   |..: ||::||
  Rat   249 FDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSP---GDDMNDRKLLY 310

  Fly   559 QTWAHPSQWYKKQPLCLVRKYFGDKIALYFCWLGFYTEMLVYPAVVGTLCFIYGLATLESEDNTP 623
            |.||....:||.||:.|:|||||:||.|||.|||.||..|:..:|:|.:.|:||.||:  |::.|
  Rat   311 QEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATI--EEDIP 373

  Fly   624 SKEICNEYGTGNITLCPLCDKACSYQRLSESCLFSRLTYLFDNPSTVFFAIFMSFWATTFLELWK 688
            |||:|:....  .|:||||||:|.|..||.:|..:|.::|||||:||||:|||:.|||.|||.||
  Rat   374 SKEMCDHQNA--FTMCPLCDKSCDYWNLSSACGTARASHLFDNPATVFFSIFMALWATMFLENWK 436

  Fly   689 RKQSVLVWEWDLHNVDMDEE-NRPEFETNATTFRM--------------NPVTREKEPYMSTW-N 737
            |.|..|.:.|||..::.:|| :|||:||......:              :|...|.:....|| :
  Rat   437 RLQMRLGYFWDLTGIEEEEEHSRPEYETKVREKLLKESGKSAVQKLEANSPEDDEDDEDKLTWKD 501

  Fly   738 RSIRFVITGSAVLFMISVVLSAVLGTILYRITLVSVIYGGGGFFVKEHAKLFTSVTAALINLVVI 802
            |...:::...::||||::..|.|.|.|:||||..:.:.....  .:.:.::..:.||.:||||||
  Rat   502 RFPGYLMNSVSILFMIALTFSIVFGVIVYRITTAAALSLNKA--TRSNVRVTVTATAVIINLVVI 564

  Fly   803 MILTRIYHRMAIKLTNLENPRTHTEYEDSYTFKIFFFEFMNFYSSLIYIAFFKGRFFDYPGD--- 864
            :||..||..:|..||.:|.|:|...:|:....|.|..:|:|.||.:.|:|||||||...||.
  Rat   565 LILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVY 629

  Fly   865 --DQARKSEFFRLKNDICDPAGCLSELCIQLAIIMVGKQ-CWNNFMEYLFPKFWNWWRQRKHK-- 924
              |..|..|        |.|.|||.||||||:|||:||| ..||..|...||....:|:.|.:
  Rat   630 VFDGYRMEE--------CAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETE 686

  Fly   925 --QATKDESHLHMAWEQDYHMQDPGRLALFDEYLEMILQYGFVTLFVAAFPLAPLFALLNNVAEI 987
              ::..|.|.....|:.||.::.  ...|..||:|||:|:||||||||:|||||:|||||||.|:
  Rat   687 PGESDPDHSKRPEQWDLDYSLEP--YTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEV 749

  Fly   988 RLDAYKMVTQARRPLAERVEDIGAWYGILRIITYTAVVSNAFVIAYTSDFIPRMVYKFVYSETHT 1052
            ||||.|.||:.|||.|.|.:|||.|:.||..|...:|:.||||||.|||||||:||::.||...|
  Rat   750 RLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYSHNGT 814

  Fly  1053 LAGYIEHSLSIFNTSDYKEEWGASVSEKDPDT--CQYRGYRNGPKDYEPYGLSPHYWHVFAARLA 1115
            |.|::.|:||.||.|..||......|:.|.:.  |:::.||..|....||..|..||.|.:||||
  Rat   815 LHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSVLSARLA 879

  Fly  1116 FVVVFEHVVFVITGIMQFIIPDVPSEVKTQMQREQLLAKE--AKYQH--------GIKRAQGDSQ 1170
            ||::|:::|..::.::.::|||:|:::..|:::|:.|..:  .|.:|        ..:|:||..
  Rat   880 FVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKVKLADEPAQRSQGGG- 943

  Fly  1171 DIMSLFRDTSNRASIAGSTVTTR 1193
                   :.|.|:..|.|..:.|
  Rat   944 -------NRSRRSRAASSAPSGR 959

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	75/273 (27%)
		Anoctamin	576..1149	CDD:461349	260/600 (43%)
Ano2	XP_017448527.2	Anoct_dimer	68..325	CDD:465044	75/273 (27%)
		Anoctamin	328..913	CDD:461349	260/600 (43%)