DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43896 and Mur89F

DIOPT Version :9

Sequence 1:	NP_001261732.1	Gene:	CG43896 / 39360	FlyBaseID:	FBgn0264488	Length:	2113	Species:	Drosophila melanogaster
Sequence 2:	NP_001262662.1	Gene:	Mur89F / 42080	FlyBaseID:	FBgn0038492	Length:	2159	Species:	Drosophila melanogaster

Alignment Length:	1590	Identity:	301/1590 - (18%)
Similarity:	486/1590 - (30%)	Gaps:	483/1590 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 NCSSYYRCTAK-----NAVRTVTCAPGKEYNPKNGKC---TMAGRSLCKLSLLAPLAEATNVCST 98
            :|:.:|||...     |.| ...|:||..::|....|   |...:..||     .:|..:...|:
  Fly   757 DCARFYRCVENGSGGFNKV-PFDCSPGTVWDPDTKGCNHPTDVQKEQCK-----AMANGSGSSSS 815

  Fly    99 EVNGAYIANSGSCGEFYICDEQIAYPQKCDLGSFFNETLAACIPDANSTCWQNLCINKTNGVFVE 163
            :.:.:...:|.|.|...............:.||..|:..::   :..|:..|....|:.:.....
  Fly   816 QGSSSNQGSSSSQGSSSNQGSSSNQGSSSNQGSSSNQGSSS---NQGSSSNQGSSSNQGSSSNQG 877

  Fly   164 NEANCGSYYVCSNGEATLQ--------TCPQGSFFN---TSVAACTVDQGNSQCWVNYCIGQDDG 217
            :.:|.||  ..|.|.::.|        :..|||..|   :|....:..||:|.   |.....:.|
  Fly   878 SSSNQGS--SSSQGSSSNQGSSSNQGSSSNQGSSSNQGSSSNQGSSSSQGSSS---NEGSSSNQG 937

  Fly   218 SAVADKSNCSLFYVCSNNTATAQECPEGSYFESNNWGCV--------PGTCTTESPCDD------ 268
            |:.:..|:       ||..:::.:....:...|:|.|..        .|:.:.:|...:
  Fly   938 SSSSQGSS-------SNQGSSSNQGSSSNQGSSSNQGSSSNQGSSSNQGSSSNQSSSSNQSSSNQ 995

  Fly   269 -------STTTTTESCAEETTEPPASCDCGDIKNADFIPDEENCRKYFICIDGVLVAADCGKGNV 326
                   |:..|:.|..::..:|...|:    ....|:.|.|||.|::.|:|.       |||..
  Fly   996 SSSNQSSSSNQTSSSTTQKPFKPAEKCE----SEETFLADNENCSKFYRCVDN-------GKGGF 1049

  Fly   327 FNANLSVCEVDADNTCCVADCTDGEAKVDPQDC-------TKYFKCQSGDWTSVSCDSGSYFNET 384
            ...:.         ||......|.||    ..|       ||..||:     .|....||..|.|
  Fly  1050 TKVSF---------TCPPNTLWDPEA----NSCNHPDQIQTKPLKCK-----KVVSQGGSSSNST 1096

  Fly   385 LNCCQVDVNNVCIDAKSNSTQIPTTSTVETSSVDKCNAKDPPASGKNCWTYQHCISGQWEDGTCP 449
            .|......|:.......:|:...::::..:|:....:.....:||.:........||........
  Fly  1097 SNSSSSSNNSGSSSNSGSSSSSSSSNSGSSSNTGSSSNSGASSSGGSSNQGSSSNSGSSSGSNSS 1161

  Fly   450 NNTYFDASVGICREDTENVCPENRSSGSRQKRSVEDC-----TCEGGIAQGTIIGHSTDCDKYLI 509
            .|....:|.......:.|....:.||.|....|....     ||:   ..|..||..:||.|:..
  Fly  1162 GNQSTSSSTSSSSSSSNNNNQGSSSSSSSSSSSTSSKPNPSETCK---VNGQFIGDRSDCAKFYR 1223

  Fly   510 CENG-----QLVEGVCGVGNVFQ------------KSSGICVPDTKATCWVCSNKPNGYQMADPT 557
            |.:.     .:|...||.|.|:.            |..|...|.|.:|  ..:::|.....:.|:
  Fly  1224 CVDNDRGGFNMVPFSCGPGTVWDAQMQACNHAWAVKECGGIAPPTTST--PTTSRPTTASTSRPS 1286

  Fly   558 DCTSY------------LTCWNGLATKHTCGSGEWY-------NGDGNC-----VIDVN-----A 593
            |.||.            :|.....::..|..|.:..       |.||.|     :.|.|     .
  Fly  1287 DQTSTSRPTGPPTTARPVTARPTTSSPTTASSSQTTSPVTQAPNTDGKCRSEGFMADPNNCSKFY 1351

  Fly   594 KCIN---------PCSCGNGNVAH---PICT-NYFQCTDGVPQV---KQCVVGEAFDSATGQCST 642
            :|:.         |..||.|.|..   ..|. |:..|:.|....   ..|.......:||...||
  Fly  1352 RCVRNNKGGFTSIPFQCGAGTVWDQDLQTCNHNFNNCSTGTESTTPKPPCEPATNGTTATSTSST 1416

  Fly   643 TVECSA-----------------------------------------------------KNCATA 654
            |.....                                                     ....|.
  Fly  1417 TTPPPTTTDLPPTSTTGLPPTTTTELPPTTTTDLPPTTTTRLPPTTTTSLPPTTTTGLPPTTTTG 1481

  Fly   655 SDGTTYPVAGETGQFYVCLSNEATIQPCPVNTGYSAALGICLDQPSPDCDQTICNSAAVDST--- 716
            :..||..::.||....|..|.|:|.||....|          .:|.|         |..:.|
  Fly  1482 AQPTTTTLSSETETSTVTTSPESTTQPPSTTT----------MKPLP---------AGTECTGEG 1527

  Fly   717 YPSNDNDSSTFCLCRDSGA----YIQSCPTGLFYDATDQVCTFSGNCDPQVCNDQSEYFV---SP 774
            |.::..|...:..|.::||    |..:||.|..::...|.|.:..|. |:.....:|...   |.
  Fly  1528 YMADPEDCRKYYRCINAGASYRKYNFTCPKGTGWNEEVQTCDYVENI-PRCSKLPAEPITTTPSE 1591

  Fly   775 DYEDPNSFCLCRAGEPITVSCPIGYTFNTEELECVLIPLPDPRCCANGCSGK----------TDF 829
            :.:||.|.......||.||:.||  |..|||........|..:......:.:          |::
  Fly  1592 ESKDPGSTTPQSTDEPTTVTKPI--TKPTEEPSTEKPQKPTTQYPEKPTTTEEPEKPQKPTTTEY 1654

  Fly   830 STFPTIEGTDGFCLCVDDVPKYISCPENSQYDLELGACTATEEET-TCPVNACTVGICESALDFN 893
            ...||.  |:      :..|:....|..::|..:   .|.|||.| ..|....|.       ::.
  Fly  1655 PQKPTT--TE------EPTPEKPQKPTTTEYPQK---PTTTEEPTPEKPQKPTTT-------EYP 1701

  Fly   894 TFPVSSDPSGFCYCLDSCPIYETCLDDLVYNEDLKRCTEPEDPSVVSRCDAEKCDSIPDF----T 954
            ..|.:.:|:     ..|.|.|                    :|:..         |:|.:    |
  Fly  1702 QKPTTEEPT-----TTSIPGY--------------------NPTTT---------SVPGYNPTTT 1732

  Fly   955 PYP--SINGTDGFCYCNGGLPVFRECEENQEFDPAVGFCRTVVDSCVTALCDANQCATLDNYVPF 1017
            |.|  :...|.|:.....|.|:                ..|.:.|..|   ||.|..|... .|.
  Fly  1733 PIPVETTTSTPGYKPTTTGEPI----------------TTTTLPSTTT---DAIQEPTTSK-KPE 1777

  Fly  1018 PTNTASDDDGAFCYCKDGEVILEQ--------CSPE------------------------MVFSA 1050
            ||.|....:.:   ..:|.|...|        ||.|                        .|::.
  Fly  1778 PTTTTESPESS---TPEGSVTTLQPEPQPNYNCSSEGFFPDPEDCSRYYRCVDAAKNGKYQVYAF 1839

  Fly  1051 DLGRCTVQAAPECVC-----APGKCGSSDGYTTYEALNTNEGFC--------------------- 1089
            ..|:.||.......|     ..|.|  |.|.||.....|..|..
  Fly  1840 KCGKGTVWDTSTETCNYADQVSGNC--SSGQTTTPGTTTEPGTTESTTSSGKPETTSKAPENTTT 1902

  Fly  1090 ----LCVSGTPVFTECLNGETYNSILGACFSST-------AKIIASGLCDDRRCHSRAVVDATFA 1143
                ...:.:|..|..:..||..:..|...::|       .|...:.:..:....|::.......
  Fly  1903 WAPETTTTSSPETTTTVASETTTTTSGTTTTATPETTTKPPKPETTTIAGEETSTSKSPTTTESP 1967

  Fly  1144 AVNT-TSGYCSCQDVGVSTFINCADEHVYEESAGTCVVAACDYTSCLNRVAFEPFEAKNTT---E 1204
            |.:| ||..|.....|.:.::.......:.|..|  :...|..::..|.:....|:..|.|   :
  Fly  1968 APSTNTSAPCPETGPGQNVYVCPTGFRRHPEKCG--MFYQCSESADNNDLNIVVFQCPNGTVYQD 2030

  Fly  1205 GFCSCDGVPYFHQC-----QTGHVFDKAQGICLLKDTMAMISCNLRECLKRSQFEP-------FA 1257
            ..|||...|...:|     :|.:.|::              ...|:..::.|..:|       ||
  Fly  2031 KSCSCGKPPAGDKCSKDMKRTTNAFEE--------------ETKLQNVVQISTTDPLCPDEGHFA 2081

  Fly  1258 AENTNSG--FCSCDDLQ---RVSVTYHPCGEGEIFAPEFGMCTSHSIQKRSVEAEENICISNEMR 1317
            ..|...|  |..|...:   |:....|.|.:|..:         .::.:|...|          |
  Fly  2082 LNNDQCGQLFVKCGFSELTGRIEGQIHRCPQGFAY---------WNVSRRCEPA----------R 2127

  Fly  1318 SVPANCSQYEMCIDG----RW-----RRRT 1338
            .:| ||:.....:.|    .|     |||:
  Fly  2128 KLP-NCTPTTYNVGGNVPLEWLNIGHRRRS 2156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43896	NP_001261732.1	CBM_14	96..147	CDD:279884	7/50 (14%)
		CBM_14	153..206	CDD:279884	15/63 (24%)
		CBM_14	211..257	CDD:279884	8/53 (15%)
		CBM_14	298..343	CDD:279884	12/44 (27%)
		CBM_14	354..395	CDD:279884	12/47 (26%)
		CBM_14	427..468	CDD:279884	6/40 (15%)
		ChtBD2	488..535	CDD:214696	15/63 (24%)
		CBM_14	544..593	CDD:279884	14/77 (18%)
		CBM_14	<1320..1361	CDD:279884	8/28 (29%)
		ChtBD2	1627..1675	CDD:214696
		CBM_14	1684..1733	CDD:279884
		ChtBD2	1752..1797	CDD:214696
		CBM_14	1820..1868	CDD:279884
		CBM_14	1896..1939	CDD:279884
		ChtBD2	2046..2091	CDD:214696
Mur89F	NP_001262662.1	CBM_14	57..106	CDD:279884
		CBM_14	200..250	CDD:279884
		CBM_14	484..536	CDD:279884
		CBM_14	745..798	CDD:279884	12/41 (29%)
		CBM_14	1025..1074	CDD:279884	17/68 (25%)
		CBM_14	1206..1261	CDD:279884	13/57 (23%)
		CBM_14	1336..1388	CDD:279884	10/51 (20%)
		CBM_14	1523..1577	CDD:279884	14/54 (26%)
		VAD1-2	<1599..>1656	CDD:291956	12/58 (21%)
		CBM_14	1809..1861	CDD:279884	6/51 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23301
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100