DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43896 and CG31077

DIOPT Version :9

Sequence 1:	NP_001261732.1	Gene:	CG43896 / 39360	FlyBaseID:	FBgn0264488	Length:	2113	Species:	Drosophila melanogaster
Sequence 2:	NP_733185.2	Gene:	CG31077 / 318583	FlyBaseID:	FBgn0051077	Length:	988	Species:	Drosophila melanogaster

Alignment Length:	1310	Identity:	282/1310 - (21%)
Similarity:	408/1310 - (31%)	Gaps:	416/1310 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 LGSFFNETLAACIPDANSTCWQNLCINK-------------TNGVFVENEANCGSYYVCSNGEAT 180
            ||..:.|..  ||     :.|  :|:.:             |.|....:..:|.||:.|.:.|..
  Fly     5 LGRMYYEVF--CI-----SAW--ICLMRPSFGSIIKDSVKCTEGSVAADIDDCASYFQCIDDETV 60

  Fly   181 LQTCPQGSFFNTSVAACTVDQ-GNSQCWVNYCIGQDDGSAVADKSNCSLFYVCSNNTATAQECPE 244
            ...|..||:|..|...|.||: |........|.   ||....|.::|..:..|.......|.||.
  Fly    61 HLNCANGSYFEASNEICVVDEFGVCPTSRRLCF---DGDIFEDINDCMSYVKCIRGDLVRQRCPA 122

  Fly   245 GSYFESNNWGCVPGTCTTESPCDDSTTTTTESCAEETTEPPASCDCGDIKNADFIPDEENCRKYF 309
            ||.|...:..|              ..:.|.|||    .|...|..|:::     .|.|:|..|.
  Fly   123 GSNFNVISKNC--------------QMSRTGSCA----SPKEICLEGELQ-----VDSEDCAGYL 164

  Fly   310 ICIDGVLVAADCGKGNVFNANLSVCEVDADNTC--CVADCTDGEAKVDPQDCTKYFKCQSGDWTS 372
            .|::|.||...|..|:.|.....:|::|.:..|  ..::|||||.:|||.:|..||.|::|...:
  Fly   165 ECLNGGLVKEKCPIGSYFEPIFKLCQLDENGVCSSSSSECTDGEVRVDPNNCAGYFNCENGRLIT 229

  Fly   373 VSCDSGSYFNETLNCCQVDVNNVCIDAKSNSTQIPTTSTVETSSVDKCNAKDPPASGKNCWTYQH 437
            .:|.||:||..|...|.||:..||::..:                 ||..........||..|..
  Fly   230 KTCPSGTYFEPTYKTCTVDLKGVCVEPPA-----------------KCTEGQLKIDPNNCAGYLK 277

  Fly   438 CISGQWEDGTCPNNTYFDASVGICREDTENVCPENRS---SGSRQKRSVEDCTCEGGIAQGTIIG 499
            ||.|::.:..||..||:|..:..|..|||.||...|.   .|.|:|
  Fly   278 CIDGEFVEEKCPGGTYYDFKLETCLVDTEGVCVTIRKLCIEGLREK------------------- 323

  Fly   500 HSTDCDKYLICENGQLVEGVCGVGNVFQKSSGICVPDTKATC---------------WVCSNKPN 549
            ...||..|..|..|::...:|..|..|..:.|.|:.|....|               :..|..||
  Fly   324 DPKDCAAYTQCIRGRVESVMCDSGRYFNVTQGECLADLYEVCLKSRKEHFRIVEHHQYDESTTPN 388

  Fly   550 GYQMADPTDCTSYLTCWNGLATKHTCGSGEWYNGDGNCVIDVNAKCINPCS-CGNGNVAHPI--C 611
            .||..:.||..          .:.|..:.:......:|:.|:|..|:...: |..|.....|  |
  Fly   389 SYQQTESTDAD----------FQSTDSALQEVTSQNSCIFDLNGACVGQSTICTEGKKQRDINNC 443

  Fly   612 TNYFQCTDGVPQVKQCVVGEAFDSAT--------GQCSTT--------VECSAKNCATASDGTTY 660
            ..|.:|.||....::|.....:||..        |.|.|:        ||...|:||    |...
  Fly   444 AGYLKCIDGEFVEEECPESTYYDSNLETCLVDNYGACVTSTSICVEGIVEEDPKDCA----GYNQ 504

  Fly   661 PVAGETGQFYVCLSNEATIQP--CPVNTGYSAALGICLDQPSPDCDQTICNSAAVDSTYPSNDND 723
            .|.|:             ::|  |.....::...|.||    .|.|:....|:.||     .|.|
  Fly   505 CVRGK-------------VEPLKCAFGRYFNGTQGECL----IDLDEVCAKSSQVD-----YDRD 547

  Fly   724 SSTFCLCRDSGAYIQSCPTGLFYDATD----QVCTFSGNCDPQVCNDQSEYFVSPDYEDPNSFCL 784
            ...|...:.:..|:      |.|..||    ...|.|.|.|            ...|.|.||:
  Fly   548 LEQFQYSQSTSEYL------LEYTNTDTTIADFSTESSNAD------------FNRYTDSNSY-- 592

  Fly   785 CRAGEPITVSCPIGYTFNTEELECVLIPLPDPRCCANGCSGKTDFS-TFPTIEGTDGFCLCVDDV 848
             ...|..|...|.....:|.:|:                  .||.| .|.|::|.|..
  Fly   593 -TDTESTTNDVPTSTEVSTFDLK------------------TTDLSLQFTTLDGVDNL------- 631

  Fly   849 PKYISCPENSQYDLELGACTATEEETTCPVNACTVGICESALDFNTFPVSSDPSGFCYCLDSCPI 913
                        |:..|.|....          |:.| |...:.|    ..|.:|:..|......
  Fly   632 ------------DINTGTCVYNN----------TLFI-EGIREVN----PQDCAGYIECFGGVAK 669

  Fly   914 YETCLDDLVYNEDLKRCTEPEDPSVVSRCD-------AEKCDSIPDFTPYPSINGTDGFCYCNGG 971
            ...|.....:||..:.|:...| .:..:.|       ....:|.|:||     ...|.|..|..|
  Fly   670 ELKCDSGRYFNETQRNCSVDVD-EICLKSDKTIVLDLQTTTESTPNFT-----TSVDPFAKCRDG 728

  Fly   972 LPVFRECEENQEFDPAVGFCRTVVDSCVTALCDANQCATLDNYVPFPTNTASDDDGAFCYCKDGE 1036
                     ....||                   ..||                  .|..|.|||
  Fly   729 ---------QLRLDP-------------------KNCA------------------GFLKCVDGE 747

  Fly  1037 VILEQCSPEMVFSADLGRCTVQAAPECV-----CAPGKCGSSDGYTTYEALNTNEGFCLCVSGTP 1096
            :..|.|.....:::...:|.|.....||     |..|        ...|..|...|:..|:.|..
  Fly   748 LKEEMCPSGFFYNSTSSKCMVDIRATCVTNIKYCIEG--------VREEDPNNCAGYRQCIRGLV 804

  Fly  1097 VFTECLNGETYNSILGACFSSTAKIIASGLCDDRRCHSRAVVDATFAAVNTTSGYCSCQ----DV 1157
            ....|..|:.:|.....|.....|:.|                      .|...|.|.:    |.
  Fly   805 QNLNCPLGQYFNVAERDCLMDVHKVCA----------------------RTEEVYKSDEVQHNDT 847

  Fly  1158 GVSTFINCADEHVYEESAGTCV--VAACDYTSCLNRVAFEPFEAKNTTEGFCSCDGVPYFHQ-CQ 1219
            |..  :...||....:..|.||  :|.|..    .:...:|    |...|:..|.......: |.
  Fly   848 GPP--MTKPDESCIRDINGVCVDPLAKCRE----GQHKLDP----NNCAGYLKCQNGELIEELCP 902

  Fly  1220 TGHVFDKAQGICLLKDTMAMISCNLRECLKRSQFEPFAAENTNSGFCSCDDLQRVSVTYHPCGEG 1284
            .|..:|....|||:                                    |.:.:.||
  Fly   903 NGFYYDFLMKICLV------------------------------------DRRGICVT------- 924

  Fly  1285 EIFAPEFGMCTSHSIQKRSVEAEENICISNEMRSVPANCSQYEMCIDGRWRRRTCSDQRYYNPEQ 1349
                         :||         ||....:...|.:|:.|..||||:.....|....|:|...
  Fly   925 -------------NIQ---------ICDEGALEEDPHDCAGYRQCIDGQVENLKCPFGTYFNVPL 967

  Fly  1350 QRCLEPRDDL 1359
            :.||...|::
  Fly   968 RDCLIDVDEI 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43896	NP_001261732.1	CBM_14	96..147	CDD:279884	5/17 (29%)
		CBM_14	153..206	CDD:279884	17/66 (26%)
		CBM_14	211..257	CDD:279884	13/45 (29%)
		CBM_14	298..343	CDD:279884	14/46 (30%)
		CBM_14	354..395	CDD:279884	17/40 (43%)
		CBM_14	427..468	CDD:279884	15/40 (38%)
		ChtBD2	488..535	CDD:214696	10/46 (22%)
		CBM_14	544..593	CDD:279884	10/48 (21%)
		CBM_14	<1320..1361	CDD:279884	13/40 (33%)
		ChtBD2	1627..1675	CDD:214696
		CBM_14	1684..1733	CDD:279884
		ChtBD2	1752..1797	CDD:214696
		CBM_14	1820..1868	CDD:279884
		CBM_14	1896..1939	CDD:279884
		ChtBD2	2046..2091	CDD:214696
CG31077	NP_733185.2	CBM_14	43..81	CDD:279884	12/37 (32%)
		ChtBD2	<212..245	CDD:214696	13/32 (41%)
		CBM_14	267..308	CDD:279884	15/40 (38%)
		CBM_14	439..472	CDD:279884	9/32 (28%)
		CBM_14	733..769	CDD:279884	12/72 (17%)
		CBM_14	881..914	CDD:279884	7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29657at33392
OrthoFinder	1	1.000	-	-		FOG0012713
OrthoInspector	1	1.000	-	-		otm50274
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23301
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950