DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43896 and Muc68E

DIOPT Version :9

Sequence 1:	NP_001261732.1	Gene:	CG43896 / 39360	FlyBaseID:	FBgn0264488	Length:	2113	Species:	Drosophila melanogaster
Sequence 2:	NP_996064.1	Gene:	Muc68E / 2768990	FlyBaseID:	FBgn0053265	Length:	1799	Species:	Drosophila melanogaster

Alignment Length:	1462	Identity:	285/1462 - (19%)
Similarity:	446/1462 - (30%)	Gaps:	464/1462 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 PQGSFF---NTSVAACTVDQGNSQCWVNYCIGQDDGSAVADKSNCSLFYVCSNNTATAQEC---P 243
            |:||..   :|:||..|..:           .::|.:.|.|.:.     :...:|..||:.   |
  Fly   590 PEGSTTREDDTTVAIETTTE-----------KREDDTTVEDSTP-----IPEESTTVAQDTTNDP 638

  Fly   244 EGSYFESNNWGCVPGTCTTESPCDDST------------------------TTTTES----CAEE 280
            |||....::......| |||.|.||:|                        :||.|.    ..|.
  Fly   639 EGSTTREDDTTVAIET-TTEKPEDDTTAEDSTPIPEESTTVAQETTYDPEGSTTREDDTTVAIET 702

  Fly   281 TTEPPASCDCGDIKNADFIPDEENCRKYFICIDGVLVAADCGKGNVFNANLSVCEVDADNTCCVA 345
            |||.|.  |...::::..||:|           ...||.:    ..::...|....| |.|..:.
  Fly   703 TTEKPE--DDTTVEDSTPIPEE-----------STTVAQE----TTYDPEGSTTRED-DTTVAIE 749

  Fly   346 DCTDGEAKVDPQDCTKYFKCQSGDWTSVSCDSGSYFNETLN-----CCQVDVNNVCIDAKS---- 401
            ..|:     .|:|.|     .:.|.|.:..:|.:...:|.|     ..:.|...|.|:..:
  Fly   750 TTTE-----KPEDDT-----TAEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIETTTEKRE 804

  Fly   402 ------NSTQIPTTSTVETSSVDKCNAKDPPAS-----------------GKNCWTYQHCISGQW 443
                  :||.||.    ||::|.:....||..|                 .::..|.:.......
  Fly   805 DDTTVEDSTPIPE----ETTTVGQETTYDPEGSTTREEDTTVAIETTTEKPEDDTTAEDSTPIPE 865

  Fly   444 EDGTCPNNTYFDASVGICREDTENVCPENRSSGSRQKRSVEDCTCEGGIAQGTIIGHSTDCDKYL 508
            |..|....|.:|......|||...|..|..:.......:|||.|...  .:.|.:...|..|.
  Fly   866 ESTTVAQETTYDPEGSTTREDDTTVAMETTTEKREDDTTVEDSTPIP--EESTTVAQDTTNDP-- 926

  Fly   509 ICENGQLVEGVCGVGNVFQKSSGICVPDTKATCWVCSNKP-NGYQMADPTDCTSYLTCWNGLATK 572
                    ||           |.....||.......:.|| :...:.|.|......|
  Fly   927 --------EG-----------STTREEDTTVAIETTTEKPEDDTTVEDSTPIPEETT-------- 964

  Fly   573 HTCGSGEWYNGDGN--------CVIDVNAKCINPCSCGNGNVAHPICTNYFQCTDGVPQ----VK 625
             |.|....|:.:|:        ..||...:             .|......:.:..:|:    |.
  Fly   965 -TVGQETTYDPEGSTTREDDTTVAIDTTTE-------------KPEDDTTVEDSTPIPEESTTVA 1015

  Fly   626 QCVVGEAFDSATGQCSTTVECSA-----KNCATASDGTTYPVAGETGQFYVCLSNEATIQPCPVN 685
            |....:...|.|.:..|||....     ::..|..|.|..|....|      ::.|.|..|....
  Fly  1016 QDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTT------IAQETTYDPEGST 1074

  Fly   686 TGYSAALGICLDQPSPDCDQTICNSAAVDSTYPSNDNDSSTFCLCRDSGAYIQSCPTGLFYDATD 750
            |              .:.|.|:    |:::|....::|::.     :....|....|.:..|.|:
  Fly  1075 T--------------REDDTTV----AIETTTEKPEDDTTV-----EDSTPIPEESTTVAQDTTN 1116

  Fly   751 QVCTFSGNCDPQ---VCNDQSEYFVSPDYEDPNSFCLCRAGEPI----------TVSCPIGYTFN 802
                     ||:   ...|.:...:....|.|..........||          |.:.|.|.|..
  Fly  1117 ---------DPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTR 1172

  Fly   803 TEELECVL----------------IPLP------------DPRCCANGCSGKTDFSTF---PTIE 836
            .|:....:                .|:|            ||    .|.:.:.|.:|.   .|.|
  Fly  1173 EEDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVGQETTYDP----EGSTTREDDTTVAIDTTTE 1233

  Fly   837 GTDGFCLCVDDVPKYISCPENS-------QYDLELGACTATEEETTCPVNACTVGICESALDFNT 894
            ..:......|..|    .||.|       ..|.|  ..|..|::||..::..|    |...|..|
  Fly  1234 KPEDDTTVEDSTP----IPEESTTVAQDTTNDPE--GSTTREDDTTVAIDTTT----EKPEDDTT 1288

  Fly   895 FPVSSDPSGFCYCLDSCPIYE---TCLDDLVYNEDLKRCTEPEDPSVVSRCDAEKCD---SIPDF 953
            ..            ||.||.|   |...|.. |:.....|..:|.:|......||.:   ::.|.
  Fly  1289 VE------------DSTPIPEESTTVAQDTT-NDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDS 1340

  Fly   954 TPYPSINGTDGFCYCNGGLPVFRECEENQEFDPAVGFCR----TVVDSCVTALCDANQCATLDNY 1014
            ||.|..:.|               ..:...:||.....|    ||.....|...:.:  .|:::.
  Fly  1341 TPIPEESTT---------------IAQETTYDPEGSTTREDDTTVAIETTTEKPEDD--TTVEDS 1388

  Fly  1015 VPFP-------TNTASDDDGAFCYCKDGEVILEQCS--PE----MVFSADLGRCTVQAAPECVCA 1066
            .|.|       .:|.:|.:|:....:|..|.:|..:  ||    :..|..:...|.....|....
  Fly  1389 TPIPEESTTVAQDTTNDPEGSTTREEDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVGQETTYD 1453

  Fly  1067 PGKCGSSDGYTTYE-----ALNTN----EGFCLCVSGTPVFTECLNGETYNSILGACFSSTAKII 1122
            |      :|.||.|     |:.|.    |........||:..|                 |..:.
  Fly  1454 P------EGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEE-----------------TTTVA 1495

  Fly  1123 ASGLCDDRRCHSRAVVDATFAAVNTTS----------GYCSCQDVGVSTFINCADEHVYEESAGT 1177
            .....|.....:|   |.|..|:.||:          |.....|  .||.:| .|....|.|...
  Fly  1496 QETTYDPEGSTTR---DDTTVAIETTTEKPEDDTTAEGSTPIPD--TSTTVN-QDTTTDESSTVV 1554

  Fly  1178 CVVAACDYTSCLNRVAFEPFEAKNTTEGFCSCDGVPYFHQCQTGHVFDKAQGICLLKDTMAMISC 1242
            ........::.|......|.|  |:|.|..|         ..|..|:|         .|.:.|..
  Fly  1555 TTTNIPKESTTLGDSTLSPGE--NSTAGQVS---------TSTTLVYD---------TTSSPIPS 1599

  Fly  1243 NLRECLKRSQFEPFAA---ENTNSGF--CSCDDLQRVSVTY----HP--------CGEGE----- 1285
            :.|.    :..||.::   |.|.|..  .||      |..|    ||        |..|.
  Fly  1600 SSRS----TTLEPSSSSSPETTTSSLPPLSC------STGYQYLPHPTNCHKYIHCSNGHELIME 1654

  Fly  1286 ------------IFAPEFGMCTSHSIQKRSVEAEENICISN-EMRSVPANCSQYEMCIDGRWRRR 1337
                        :.:.:.|:|.:.:   .:...||.:|... :..:.|.:|:.|..|.:|....|
  Fly  1655 CPANLYWDYHKFVCSGDSGVCYNDT---ENSNPEEKVCGPGVDFLAHPTDCTMYLQCSNGVALER 1716

  Fly  1338 TCSDQRYYNPEQQRCLEPRDDLVCAYARVSNIPTCTAISESMTIPAKSGNCMQYFRCSGGKWRLR 1402
            .|.|..|:|||.:.|  ...:..|...|.|...:|.|   .|.......:|.:|.:|.|.:..:.
  Fly  1717 KCPDPLYWNPEIKSC--DWSNKYCTNLRASQSISCAA---GMNFNVFQSDCSKYVKCFGLRGVVM 1776

  Fly  1403 NCPKQHYYSPLIGSCLPFPRGHEQDRNQTICS 1434
            :|....|::|:...|         ::::..|:
  Fly  1777 SCNSGLYWNPVSQVC---------EKSRRFCT 1799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43896	NP_001261732.1	CBM_14	96..147	CDD:279884
		CBM_14	153..206	CDD:279884	7/23 (30%)
		CBM_14	211..257	CDD:279884	10/48 (21%)
		CBM_14	298..343	CDD:279884	9/44 (20%)
		CBM_14	354..395	CDD:279884	9/45 (20%)
		CBM_14	427..468	CDD:279884	9/57 (16%)
		ChtBD2	488..535	CDD:214696	6/46 (13%)
		CBM_14	544..593	CDD:279884	11/57 (19%)
		CBM_14	<1320..1361	CDD:279884	13/40 (33%)
		ChtBD2	1627..1675	CDD:214696
		CBM_14	1684..1733	CDD:279884
		ChtBD2	1752..1797	CDD:214696
		CBM_14	1820..1868	CDD:279884
		CBM_14	1896..1939	CDD:279884
		ChtBD2	2046..2091	CDD:214696
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696	7/29 (24%)
		ChtBD2	1626..1668	CDD:214696	7/47 (15%)
		ChtBD2	1688..1734	CDD:214696	14/47 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D33909at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23301
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020