DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43896 and cbd-1

DIOPT Version :9

Sequence 1:	NP_001261732.1	Gene:	CG43896 / 39360	FlyBaseID:	FBgn0264488	Length:	2113	Species:	Drosophila melanogaster
Sequence 2:	NP_502145.2	Gene:	cbd-1 / 178061	WormBaseID:	WBGene00010351	Length:	1319	Species:	Caenorhabditis elegans

Alignment Length:	1588	Identity:	312/1588 - (19%)
Similarity:	476/1588 - (29%)	Gaps:	505/1588 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 GRSLCKLSLLA----------PLAEATNVCSTEVNGAYIANSGSCGEFYICDEQIAYPQKCDLGS 131
            |..|..:|||.          |.:.|...|....|| .||.:....|:.||...:.....|...|
Worm     2 GPQLATVSLLLLTFFSNSIQYPHSPAATECPAYFNG-NIAGNACSREYSICVNGVRQAATCSDDS 65

  Fly   132 FFNETLAACIP-DANSTCW--QNL-----------CINKTNGVFVENEANCGSYYV-CSNGEATL 181
            .|.|.  .|:| |.:..|.  :|.           |.:|.:|::   ...|.:.:: |..|.|.:
Worm    66 VFYED--ECVPVDESPECRVDENTEEDDTPYAEFDCTSKQDGIY---SIGCSNQFISCVAGGAYM 125

  Fly   182 QTCPQGSFFNTSVAAC-----TVDQGNSQCWVNY------------------------------- 210
            ..||....||.....|     .|.|..:.....|
Worm   126 AKCPDSLVFNERTQDCRESCDEVKQDTTTAPQVYEDGEEGYGEASGEIAGDYERQPSNEQPDSID 190

  Fly   211 --CIGQDDGSAVADKSNCSLFYVCSNNTATAQECPEGSYFESNNWGCVPGTCTTESPCDDSTTTT 273
              |.|.:||: .||..| .:||.||||....:.||.|:.|..|...| ...|||    ||.|||.
Worm   191 FDCNGLEDGN-YADGCN-DVFYSCSNNMVFQRYCPPGTVFNINQQSC-DFQCTT----DDPTTTV 248

  Fly   274 TESCAEETTEPPASCDCGDIKNADFI-----PDEENCRKYFICIDGVLVAADCGKGNVFNANLSV 333
            :.|.:..||......:.....:||.|     |.          ||.:              ..:.
Worm   249 SYSTSTITTPQEDDSEYSSTTSADVISTTTTPS----------IDAI--------------ETTT 289

  Fly   334 CEVDADNTCCVAD----CTDGEAKVDPQDCTKYFKCQSGDWTSVSCDSGSYFNETLNCCQVDVNN 394
            ...||..|.....    |.:|:........:::.:||:....|..|...:.|..:|..|..|
Worm   290 TGFDAVTTTTTTQTPFVCQEGQVNSFGMCSSRFNRCQNNSVRSKQCPVNTLFESSLVMCVFD--- 351

  Fly   395 VCIDAKSNSTQIPTTSTVETSSVDKCNAKDPPAS------GKNC---------WTYQHCISGQWE 444
                       :|....:...:....|:..||:.      .:|.         ..|.|   |:..
Worm   352 -----------LPQCQPITVPAAPAYNSYGPPSDTIVSPFDENVRLKPKFDRRRKYHH---GKPS 402

  Fly   445 DGTCPNNTYFDASVGICREDTENVCPENRSSGSRQKR---------SVEDCTCEGGIA------- 493
            .|....|:|.:....|         |.:|....|..|         |.......|..|
Worm   403 YGPVNGNSYLENPFFI---------PRHRGGSHRDHRRYGYGPAIDSPFSTAFRGRAALSDQFKD 458

  Fly   494 -----QGTIIGHSTDCD---KYLICE-----NGQLVEGVCGVGNVFQKSSGICVPDTKATCWVCS 545
                 .|.|.|.:...|   ::||.:     |.:.||.  .:..||.|:..             |
Worm   459 YRRARMGKIQGDARKVDGNKRFLIDDEFEGPNAKFVES--NIEQVFPKNRH-------------S 508

  Fly   546 NK-------PNGYQMADPTDCTSYLTCWNGLATKHT----CGSGEWYNGDGNCVIDVNAKCIN-P 598
            .|       |:||......|......     ||:..    .|:.:...|..:..|......:| .
Worm   509 KKQLGPHEDPDGYDDEKTFDAKDLFG-----ATRRKRSAYYGTEQSVYGQQSAQISARQAQVNKD 568

  Fly   599 CSCGNGNVAHPICTNYFQCTD--------GVPQVKQCVVGEAFDSATGQCSTTVECSAKNCATA- 654
            |.    ....|....:..|.|        |:.::..|.:||.||.....||.|  |.......|
Worm   569 CQ----QYTTPTFLTFGDCFDQFIFCSGNGINRMAACPIGETFDKTLRSCSET--CGVSTTIVAV 627

  Fly   655 ------SDGTTYPVAGETGQFYVCLSNEATIQPCPVNTGYSAALGICLDQPSPDCDQTICNSAAV 713
                  ||..:.|     .::   :.|:........|           ||||  ..|...:..:.
Worm   628 TIGTQTSDDLSAP-----SEY---IENDGVTTQSTWN-----------DQPS--TTQAPNSYESY 671

  Fly   714 DSTYPSNDNDSST-----------------------FCLCRDSGAYIQSCPTGLFYDATDQVCTF 755
            .:.|.|||..|::                       :..|.:..|.::.|...|:::...|.||:
Worm   672 TTQYSSNDVPSTSAAPIGDRCSLDASGLFSLGCSQKYIQCSNGAAIVRRCGESLYFNEATQECTY 736

  Fly   756 SGNCDPQVCNDQ----SEYFVSPDYEDPNSFCLCRAGE-PITVSCPIGYTFNTEELECVLIPLPD 815
            .... |: |..|    |....:|..:..:::....:.: |.|...|:|..
Worm   737 RDEV-PE-CGSQGSTSSPVITTPGQDQSSNYYGIPSDDVPSTTQTPVGDR--------------- 784

  Fly   816 PRCCANGCSGKTDFSTFPTIEGTDGFCLCVDDVPKYISCPENSQYDLELGACTATEEETTCPVNA 880
               ||...||..|...      :..:..|.|.......|..:..:|....:|...:|...|.
Worm   785 ---CAYVASGLFDLGC------SQKYIQCSDSAASVRECEGSLYFDERSQSCRFRDEVFKCQ--- 837

  Fly   881 CTVGICESA----LDFNTFPVSSDPSGFCYCLDSCPIYETCLDDLVYNEDLKRCTEPEDPSVVSR 941
             |..:..|:    |||.|.|.|  ||.     |....||..:             .|..|||...
Worm   838 -TADVSSSSTVPYLDFTTTPAS--PSE-----DEPTTYEPSV-------------APYIPSVTVN 881

  Fly   942 CDAEKCDSIPDFTPYPSINGTDG-------FCYCNGGLPVFRECEENQEFDPAVGFCRTVVDSCV 999
             ..:.|.|:.|        ||.|       |...:|.|.....|:..:.:||:|..|||..:...
Worm   882 -PVDTCTSLSD--------GTHGTGCSSFYFVCSHGRLISSGNCQLGEGYDPSVQGCRTFSEIPA 937

  Fly  1000 TALCDANQCAT---LDNYVPFPT--NTASDDDGAFCYCKDGEVILEQCSPEMVFSADLGRCTVQA 1059
            .| ||..:..|   |...:|:.|  ...:..:.|.....||.............:.|.|..|:..
Worm   938 RA-CDEQEVTTDAGLVQLMPYKTLEEVLTTTEAATTVANDGPTDTYITGSTKYSTTDSGEYTIPY 1001

  Fly  1060 APECVCAPGKCGSSDGYTTYEALNTNEG----------FCLCVSGTPV------FTECLNGETYN 1108
            ..|..       |:..|.  .|.|.:|.          .|...|.|||      :.||.:.....
Worm  1002 GDETT-------STRSYD--RADNDSEDEEEDDVEHDQKCTVGSRTPVGFCVRTYLECTDAGNVE 1057

  Fly  1109 SI--LGACFSSTAKIIASGLCDDR-RCHSRAVVDATFAAVNTT---------SGYCSCQDVGVST 1161
            .:  :|..|.|     .|..|..| .|...|:.||....:.||         .|.|:
Worm  1058 KLCRIGKLFDS-----HSNRCVPRIGCGKEAIRDAIKDMIATTPAPAQPKQFEGRCA-------- 1109

  Fly  1162 FINCADEHVYEESAGTCVVAACDYTSCLNRVAFEPFEAKNTTEGFCSCDGVPYFHQCQTGHVFDK 1226
                   ||..|:..:..|.:..|..|                    ..|.....||....||..
Worm  1110 -------HVDGEAVFSIGVCSSKYLRC--------------------SYGASKLQQCSEDRVFSN 1147

  Fly  1227 AQGICLLKDTMAMISCNLRECLKRSQFEPFAAENTNSGFCSCDDLQRVSVTYHPCGEGEIFAPEF 1291
            .:..|:::::::  :|.:.   |....:.:...|..|.||
Worm  1148 DKLECIVRESVS--ACTVP---KNPSIKKYYTSNDQSAFC------------------------- 1182

  Fly  1292 GMCTSHSIQKRSVEAEENICISNEMRSVPANCSQYEMCIDGR-WRRRTCSDQRYYNPEQQRCLEP 1355
                         :.:|:....||     .:||....|..|. :...:|.....:|....:|..|
Worm  1183 -------------DGKEDGLYRNE-----RDCSAILQCFGGELFEHPSCQSSLAFNQLTGKCDYP 1229

  Fly  1356 RDDLVCAYARVSNIPTCTAISESMTIPAKSGNCMQYFRCSGGKWRLRNCPKQHYYSPLIGSCLPF 1420
            :....|.....:| ..|   ||..:..|.:.||..::||..|:..:..||....::||:
Worm  1230 QKVSGCENHGQTN-GEC---SEHGSFIADANNCEVFYRCVWGRKVVMTCPSGTVFNPLL------ 1284

  Fly  1421 PRGHEQDRNQTICSW--AMSKLAGNSSD 1446
                      ::|.|  |:...:|.:||
Worm  1285 ----------SVCDWPSAVPSCSGQASD 1302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43896	NP_001261732.1	CBM_14	96..147	CDD:279884	15/51 (29%)
		CBM_14	153..206	CDD:279884	14/58 (24%)
		CBM_14	211..257	CDD:279884	19/45 (42%)
		CBM_14	298..343	CDD:279884	7/49 (14%)
		CBM_14	354..395	CDD:279884	8/40 (20%)
		CBM_14	427..468	CDD:279884	8/55 (15%)
		ChtBD2	488..535	CDD:214696	14/66 (21%)
		CBM_14	544..593	CDD:279884	11/59 (19%)
		CBM_14	<1320..1361	CDD:279884	8/41 (20%)
		ChtBD2	1627..1675	CDD:214696
		CBM_14	1684..1733	CDD:279884
		ChtBD2	1752..1797	CDD:214696
		CBM_14	1820..1868	CDD:279884
		CBM_14	1896..1939	CDD:279884
		ChtBD2	2046..2091	CDD:214696
cbd-1	NP_502145.2	ChtBD2	97..141	CDD:214696	11/46 (24%)
		ChtBD2	191..237	CDD:214696	19/48 (40%)
		CBM_14	692..743	CDD:307643	8/52 (15%)
		CBM_14	785..836	CDD:307643	11/56 (20%)
		CBM_14	1108..1161	CDD:307643	13/89 (15%)
		CBM_14	1182..1235	CDD:307643	12/95 (13%)
		CBM_14	1251..1296	CDD:307643	13/60 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167717
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I2936
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D487374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.900