DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43896 and C08G9.2

DIOPT Version :9

Sequence 1:	NP_001261732.1	Gene:	CG43896 / 39360	FlyBaseID:	FBgn0264488	Length:	2113	Species:	Drosophila melanogaster
Sequence 2:	NP_501249.1	Gene:	C08G9.2 / 177545	WormBaseID:	WBGene00015620	Length:	2224	Species:	Caenorhabditis elegans

Alignment Length:	2438	Identity:	494/2438 - (20%)
Similarity:	702/2438 - (28%)	Gaps:	995/2438 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LTAVVALVGAADPE-CIYRRTR-NL--PMHWPKPL--NCSSYYRCT-AKNAVRTVTCAPGK---- 64
            |::.:.|:.|:.|. |.:|.|. ||  |..:.|.:  .|.    || |.:..:|..|.|.:
Worm    13 LSSSIDLLPASVPNVCPFRPTSCNLLCPFGYLKDILQQCI----CTCAMDPCQTTICGPSESCIA 73

  Fly    65 ---------EYNPKNGKCTMAGRSLCKLSLLAPLAEATNVCSTEVNGAYIANSGSCGEFYICDEQ 120
                     ::.....:|......:|.|.     .|..:.||    |..|..|..||.  .|...
Worm    74 IGVKARCIPKFGSNREECPRLTGGICALR-----CEKDSDCS----GRLICCSNGCGR--ECVAP 127

  Fly   121 IAYPQKCDL---------------GSF--------------FNETLAACIPD-----ANS----- 146
            ||...:.|.               |||              ||.|   .||.     |||
Worm   128 IAKSFQIDREVPIQPVSSSSNNIPGSFQRLIKAVSNIGSTHFNIT---PIPPTIRNLANSLFPTP 189

  Fly   147 -----------------TCWQNLCINKTNGVFVENEANCGSYYVCSNGEATLQTCPQ-------- 186
                             |..:::||::..   ..|:.:|||...|.. .|...||.:
Worm   190 SPIRPLPTTKVGQCPSPTSNKSICIDQKQ---CANDLDCGSVDKCCQ-NACGSTCMEPLKATGCI 250

  Fly   187 -------------------------GSFFNTSVAACTVDQGNSQCWVNYCIGQDDGSAVADKSNC 226
                                     |.|   |...|.:    ..||   |:....||.:|
Worm   251 HMVLAISKLKDKRLPNEFVPFCERNGRF---SSIQCDI----QFCW---CVDVHYGSEIA----- 300

  Fly   227 SLFYVCSNNTATAQE------CPEGSYFESNNWGCVPGTCTTE--SPCDDSTTTTTESCAEETTE 283
                    .|..::|      |.|            |..||.:  :.|..........|
Worm   301 --------GTRISREQRRIDMCRE------------PRLCTKKCHNQCTHGHVMDIFGC------ 339

  Fly   284 PPASCDCGDI-KNADFIPDEENCRKYFICIDGVLVAADCGK-------------------GNVFN 328
            |.|||.|.|| :|.:.....|.|:         ||..||..                   ..:.|
Worm   340 PIASCSCVDICRNVNCENTWEQCQ---------LVEPDCANPPCLPVPRCLLNPCRHGPPSRLGN 395

  Fly   329 ANLSVCEVDAD---NTCC------VADCTDGEAKVDPQDCTKYFKC--QSGD------WTSVSCD 376
            ...::|.:|.|   .||.      :..|..|     |...|:..:|  |:.|      :...||.
Worm   396 GITALCSIDKDCPEGTCSKIGYNGLGFCCSG-----PASSTRDGRCPSQAADKLKCLIYPDNSCH 455

  Fly   377 SGSYFNETLNCCQVDVNNVCID-----AKSNSTQIPTTSTVETSSVDKCN----------AKDPP 426
            |....:|...||.......|..     .|.....|......:...|:|.|          ..|..
Worm   456 SDHECSEDEKCCFNGCTLSCTQPEDYVLKKPLKPIEPVMHYQPGDVEKYNKGHLSSLVADCIDII 520

  Fly   427 ASGKNCWTYQHCISGQWEDGTCPNNTYFDASVGI---CREDTENVC--PENRSSGSRQKRSVEDC 486
            ||..:|.|..|      .|..|         .|:   ||:.....|  |. ||:         .|
Worm   521 ASNVSCATECH------SDSQC---------AGMKRCCRQGCSTSCMYPV-RST---------PC 560

  Fly   487 TCEGGIAQGTIIGHSTDCDKYLICENGQLVEGVCGVGNVFQKSSGICVPDTKATCWVCSNKPNGY 551
            ......|:...:.::..||:....|..|..:..|...::   ::|..:|.::|    ...|||
Worm   561 FHLALTAELYSLRNAMKCDRAGNFEQYQCDDEGCFCVDI---ATGEELPGSRA----IGRKPN-- 616

  Fly   552 QMADPTDCTSYLTCWNGLATKHTCGSGEWYNGDGNCVIDVNAKCINPC---SCGNGNVAHPICTN 613
                   |.|...| ..|..|..|..| :..|..:|   ...||.|||   .|..|:|.......
Worm   617 -------CESRNPC-EPLVCKVACPFG-FERGSNSC---PTCKCKNPCKEVKCPQGSVCVMSSIQ 669

  Fly   614 YFQCTDGVPQ----VKQCVVGEAFDSATG---QCSTTVEC--SAKNC---ATASDG---TTYPVA 663
            .:|..:.|||    :..|..||.:.|:.|   .|:...||  |...|   ..||.|   .:.|:.
Worm   670 CYQKGNCVPQPRCVLNFCPAGEPYISSIGNAESCTKDEECPTSTHWCHKLGLASGGMCCLSPPLV 734

  Fly   664 GETGQF-YVCLSNEATI--QPCPVNTGYSAALGICLDQPSPDC---------------------- 703
            ...|.. .|.:|.:|.:  ..|.|:...|.....|.|.....|
Worm   735 RHAGSCPIVPISLDAKMCRVSCKVDDDCSGHQKCCFDGCGAGCRDIATPLIEISKEIFEKAGTCI 799

  Fly   704 --DQTICNSAAVDSTYPSNDNDSSTFCLCRDSGAYIQSCPTGLFYDATDQVCTF-------SGNC 759
              .:.:||  .::......|.|.:....|.|.|. :::|.    |......|..       .|..
Worm   800 SEQRVLCN--RLEKNTCEYDTDCAGVAKCCDDGC-VKACA----YPLQTSKCLVRKTNLQKMGQM 857

  Fly   760 DPQVCN-DQSEYFVSPDYEDPNSFCLC-----------RAGEPITVSCPIGYTFNTEELECVLIP 812
            |...|. |.|...:..|.|    ||.|           |.||.||.:||    ...|:|||..|.
Worm   858 DLIKCRPDGSFEQIQCDTE----FCWCVDEEGNYVEGTRTGEDITPNCP----EPCEKLECGTIG 914

  Fly   813 L-----PDPRCCA-----NGCSGKTDFSTFPTIEGTDGFCL-----CV----DDVPKYI--SCP- 855
            .     .|.|.||     :.|.|.|.        |.|..|:     ||    ..:|:.|  .||
Worm   915 CEYGHKKDKRGCATCDCVDPCEGVTC--------GIDSLCVPTTVPCVTKPCPTIPRCIINPCPI 971

  Fly   856 -----------------ENSQYDL-----------ELG-ACTATEEETTCPVNACTVGICESALD 891
                             .|..:|.           |.| .|||...||       .||.|....|
Worm   972 SEAVKNETSLHLKKCYRSNDCFDAIMTTHCSMVTQEFGFCCTAESPET-------HVGTCPKITD 1029

  Fly   892 FNTFPV---------SSD---------------------------PS----------GFC----- 905
            .||..|         .||                           ||          |.|
Worm  1030 LNTAKVEKCIQECKTDSDCGQTSKCCWNGCGLTCVTSSISRIVPTPSIQQTMPGTHFGECLNVAP 1094

  Fly   906 ---YCL-----------DSCP-IYETCLDDLVYNEDLKRCTEP---------------------- 933
               :||           |.|| :|:.|.|..|     .|||:|
Worm  1095 LGAFCLQRPTIADCKNDDDCPSLYKCCSDGCV-----MRCTQPHRAPLCIHQRIAALTIAKSEGV 1154

  Fly   934 ----EDPSV--------------------------------------VSRCD----------AEK 946
                :|..|                                      |..||          ||:
Worm  1155 ESNEKDSGVFIPDCDLNGNFDEVQSHFGLMWCVGRSGQEIAGTKSTRVPNCDDPRPCPTRFCAEQ 1219

  Fly   947 CDSIPDFTPYPSINGTDGFCYCNGGLPVFRECEENQEF--DPAVGFCRTVVDSCVT------ALC 1003
            |       ||       ||...|.|.|:. :|....||  .||...||.:...|.|      |.|
Worm  1220 C-------PY-------GFNSDNEGCPIC-DCRSPCEFLNCPAGNVCRMIPVKCTTPECRPVAKC 1269

  Fly  1004 DANQCAT-----LDNYV------------PFPTNTASDDDGAFCYCKDGEVILE--QCS--PEMV 1047
            ..|.|.|     |:|::            .:....:...|.:|| |...||..:  :|.  |.|:
Worm  1270 IPNMCGTGEPLALENHLLATCSPISSCPAGYHCKNSGYGDISFC-CSTPEVAQQSLRCPVIPIML 1333

  Fly  1048 FSADLGRCTVQAAP--ECV---CAPGKCGSSDGYTT----YEALNTNEGF--------------- 1088
            .|.|...|.|....  :|.   |....||:|..:.|    .:.:.|.:.|
Worm  1334 ASVDGSSCVVGCRHHYDCTHSSCCYNGCGTSCQFETRQLAIKPIKTLKPFKPSKPSKTTRRPILS 1398

  Fly  1089 --------------------CLCVSGTPVFTECLNGETYNSILGACFSSTAKIIASGLCDDRRCH 1133
                                .|.||..|       |:     ||.|    .|::.:..|.::
Worm  1399 SLKIEKKASKIENVIVEHHAVLPVSPAP-------GK-----LGTC----PKLLINPGCTEQ--- 1444

  Fly  1134 SRAVVDATFAAVNTTSGYCSCQDVGVSTFINCADEHVYEESAGTCVVAACDYTSCLNR-VAFEPF 1197
                              || ||.....|:.|.     :.|.||...|....|:|::| :|||..
Worm  1445 ------------------CS-QDSDCHGFLKCC-----QASCGTMCSAPRIATACIHRLIAFESN 1485

  Fly  1198 EAKN-----------TTEGF---CSCDGVPYFHQCQTGHVFDKAQGICLLKDTMAMI-----SCN 1243
            .|..           |.||.   ..||.  ..:||   ...|||.|:..:...:..|     .||
Worm  1486 IASEIVNLIIPPVQCTPEGLFRKYQCDA--RLNQC---WCVDKATGVEEIGTRLFTIGLQSPDCN 1545

  Fly  1244 L-----RECL-KRSQFEPFAAENTNS-----GFCSCDD--------------LQRVSVTYHPCGE 1283
            |     .:|: .|.   |:......|     |.|.|.:              |:||..|.:||
Worm  1546 LPKSCPTQCIGSRC---PYGIRTDGSGCPANGVCECINICSTFNCPQNMECALRRVECTSNPC-- 1605

  Fly  1284 GEIFAPEFGMCTSHS--IQKRSVEAEENICISNEMRSVPANCSQYEMCI-DGRWRRRTCSDQRYY 1345
                 |:...|....  |.:|.:.....:|.::      ..|.:...|: :.:.....|..|::.
Worm  1606 -----PDVPFCVEVQCPIPQRDLYRNVILCEND------GGCGKNSKCVLNPKTEMGICCHQKHT 1659

  Fly  1346 NPEQQRCLEPRDDLVCAYARVSNIPTCTAISESMTI-----PAKSGNC------MQYFRCSGG-- 1397
            .......:.|.  :|.|...|....|......|..:     .:.|.||      ::|...:|.
Worm  1660 QSSVLNLISPA--IVAAAPEVIEATTIVDRGNSPVVVEAVPMSLSTNCTTMRIALEYLHQNGAVL 1722

  Fly  1398 KWRLRNCPKQHYYSPLIGSCLPFPRGHEQDRNQTICS----WAMSKLAGNSSDDCQHLAVRPSLA 1458
            |..|..|.:...|                  :||.|.    |.:.:|:|...    |...:....
Worm  1723 KSPLPVCSRNGNY------------------DQTQCDNKRCWCVDELSGEEI----HGTRKKKTK 1765

  Fly  1459 GGCQSYLMCLDN-SWWLHQCPLGMYFSR--------------EHNYCLPNDAGQCILPAERSGNC 1508
            ..|:|..|||.. |..|  ||.|:....              ||..| || |..|||   |..:|
Worm  1766 NACKSQSMCLSKCSTSL--CPYGLVLDSIGCPRSECICKSACEHVEC-PN-AQVCIL---RKADC 1823

  Fly  1509 SNGESRSVVGSCHSYEVCSDNGQWIRRRCQEREQFEPMLGCVPSDGSCQ----DNGMRRICREGE 1569
            .|                    :|                |:|.. :|:    ::|:|.:. |..
Worm  1824 PN--------------------KW----------------CLPVP-TCEKSPCNSGLRPLI-ETR 1850

  Fly  1570 LQAQFGNNCSQGFL-----YCEA--EEWHLGSCLKGHSFARNRNKCQLQSQCQLQIRDLPAENQC 1627
            .:.|:  :|:|..:     ||.|  :..| |.|..|.:..::
Worm  1851 TRQQY--SCTQSTVCPVGYYCTAFDDNMH-GVCCPGANSIKS----------------------- 1889

  Fly  1628 LGQIDGLSVP--DP----TDCTRFYLCLQQVPTILQSCSSGSFFDSNQGYCRPNDGSCQLAICNG 1686
            :|:.:||:.|  ||    .|.|.|     ....:...|.:       ..||....|. :..||
Worm  1890 IGEHNGLTCPHGDPFSSLADGTPF-----SCTVLTNGCPA-------THYCSTMPGQ-KKGIC-- 1939

  Fly  1687 LEDGKLVAHPEDCRS-YYSCSSQNGTSLVQCDEGQYFHSLL--SICRVDHGQCRKVSNQDETETA 1748
                        |.| .|.|:.|...........::|:|.|  |....|:|.|....|...|...
Worm  1940 ------------CVSKRYVCNLQRDAGPCTATVTRFFYSSLTHSCTPFDYGGCSGNLNNFATRDD 1992

  Fly  1749 PRLCYGLHGVKLPHELYCNLYYACVKGLAIPVECPVQHQFNPVLSICEPES-QAVQPCSNGQLDG 1812
                             ||.:.|   |:.:.:..|..|...||    ..|| |.....|.|::
Worm  1993 -----------------CNNFCA---GIGLDLSSPYDHASAPV----PTESYQIAFTLSGGKI-- 2031

  Fly  1813 NVSYVYRCGNLQDGTFLANRTDCTRYFICAGGV 1845
                  :...:||.......|...|:.|..|.:
Worm  2032 ------KSTKMQDAEIQLINTLVERFKIPRGSI 2058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43896	NP_001261732.1	CBM_14	96..147	CDD:279884	22/106 (21%)
		CBM_14	153..206	CDD:279884	14/85 (16%)
		CBM_14	211..257	CDD:279884	8/51 (16%)
		CBM_14	298..343	CDD:279884	11/66 (17%)
		CBM_14	354..395	CDD:279884	11/48 (23%)
		CBM_14	427..468	CDD:279884	10/43 (23%)
		ChtBD2	488..535	CDD:214696	7/46 (15%)
		CBM_14	544..593	CDD:279884	12/48 (25%)
		CBM_14	<1320..1361	CDD:279884	5/41 (12%)
		ChtBD2	1627..1675	CDD:214696	12/53 (23%)
		CBM_14	1684..1733	CDD:279884	10/51 (20%)
		ChtBD2	1752..1797	CDD:214696	8/44 (18%)
		CBM_14	1820..1868	CDD:279884	6/26 (23%)
		CBM_14	1896..1939	CDD:279884
		ChtBD2	2046..2091	CDD:214696
C08G9.2	NP_501249.1	WAP	90..127	CDD:278522	12/47 (26%)
		WAP	201..243	CDD:278522	11/45 (24%)
		TY	249..308	CDD:238114	11/81 (14%)
		WAP	434..478	CDD:278522	10/43 (23%)
		WAP	522..554	CDD:278522	10/46 (22%)
		TY	577..619	CDD:214561	12/57 (21%)
		WAP	738..779	CDD:278522	10/40 (25%)
		TY	861..903	CDD:214561	15/49 (31%)
		WAP	1022..1065	CDD:278522	8/42 (19%)
		TY	1138..1205	CDD:238114	3/66 (5%)
		WAP	1430..1469	CDD:278522	13/69 (19%)
		TY	1475..1544	CDD:238114	18/73 (25%)
		TY	1705..1768	CDD:238114	14/84 (17%)
		Lustrin_cystein	1898..1940	CDD:291299	12/68 (18%)
		Kunitz_BPTI	1946..1997	CDD:278443	13/67 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000