DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LCP1 and Fim

DIOPT Version :9

Sequence 1:NP_002289.2 Gene:LCP1 / 3936 HGNCID:6528 Length:627 Species:Homo sapiens
Sequence 2:NP_728074.1 Gene:Fim / 32721 FlyBaseID:FBgn0024238 Length:641 Species:Drosophila melanogaster


Alignment Length:623 Identity:334/623 - (53%)
Similarity:420/623 - (67%) Gaps:31/623 - (4%)


- Green bases have known domain annotations that are detailed below.


Human     9 EEMMELREAFAKVDTDGNGYISFNELNDLFKAACLPLPGYRVREITENLMATGDLDQDGRISFDE 73
            |....|.|....:|.:.:|:|..:||.|........|.||:|||:.:...........|:::.:|
  Fly    15 EFKQNLEELIPNLDANKDGFIDLHELKDALNQVGFKLAGYQVREMIDEYKGKQLTAFQGKLNLEE 79

Human    74 FIKIFHGLKSTDVAKTFRKAINKKEGICAIGGTSEQSSVGTQHSYSEEEKYAFVNWINKALENDP 138
            |..:...|||.|||.||:..::|||.:..:||.|..||.||.||...||:.||.:|||..|.:|.
  Fly    80 FEALCLDLKSKDVASTFKTVVSKKENLETLGGMSSISSEGTTHSVRLEEQLAFSDWINSNLGHDK 144

Human   139 DCRHVIPMNPNTNDLFNAVGDGIVLCKMINLSVPDTIDERTINKKKLTPFTIQENLNLALNSASA 203
            |.:|::|::.....|:.::.|||:|||:||.|.|||||||.||||.||.:...|||.|||.|:.|
  Fly   145 DLQHLLPIDSEGKRLYLSIKDGILLCKIINHSCPDTIDERAINKKNLTVYREFENLTLALVSSQA 209

Human   204 IGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIELSRNEALIALLREGESLEDLMKLSPEE 268
            |||::|||.|.||.:|||:||||||||:|:||||:.|.|.....|..||.:.|.||||||:|||.
  Fly   210 IGCNIVNIDAHDLAKGKPHLVLGLLWQIIRIGLFSHITLDSCPGLAGLLFDNERLEDLMKMSPEA 274

Human   269 LLLRWANYHLENAGCN-KIGNFSTDIKDSKAYYHLLEQVAPKGDEEGVPAVVIDMSGLREKDDIQ 332
            :||||.|:|||.||.: :..||.:||.||:.|.|||:|:|  |::..|     ::..|||.|...
  Fly   275 ILLRWVNHHLERAGISRRCTNFQSDIVDSEIYSHLLKQIA--GNDADV-----NLDALRESDLQS 332

Human   333 RAECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNRYPALHKPENQDIDWGALEG----- 392
            |||.|||||.:|.||.|:|..|||.|..||||||:|||||.:|.|.|||.       :||     
  Fly   333 RAEIMLQQAAKLNCRSFLTPQDVVNGVYKLNLAFVANLFNNHPGLDKPEQ-------IEGLESIE 390

Human   393 ETREERTFRNWMNSLGVNPRVNHLYSDLSDALVIFQLYEKIKVP--VDWNRVNK--PPYPKLGGN 453
            |||||:|:||||||:||.|.||.|||||:|.||||||::.|| |  |:|:||:|  .|..|.   
  Fly   391 ETREEKTYRNWMNSMGVAPHVNWLYSDLADGLVIFQLFDVIK-PGIVNWSRVHKRFSPLRKF--- 451

Human   454 MKKLENCNYAVELGKNQAKFSLVGIGGQDLNEGNRTLTLALIWQLMRRYTLNILEEIGG-GQKVN 517
            |:|||||||||:||| |.|||||||.|||||:||.||||||||||||.|||:||..:.. |..:.
  Fly   452 MEKLENCNYAVDLGK-QLKFSLVGIAGQDLNDGNATLTLALIWQLMRAYTLSILSRLANTGNPII 515

Human   518 DDIIVNWVNETLREAKKSSSISSFKDPKISTSLPVLDLIDAIQPGSINYDLLKTENLNDDEKLNN 582
            :..||.|||..|.||.|.|.:.:|.||.|:....|:||||||:.|||||:|::|....:| .|.|
  Fly   516 EKEIVQWVNNRLSEAGKQSQLRNFNDPAIADGKIVIDLIDAIKEGSINYELVRTSGTQED-NLAN 579

Human   583 AKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLM 620
            |||||||||||||||||||||:.||.||||||||||:|
  Fly   580 AKYAISMARKIGARVYALPEDITEVKPKMVMTVFACMM 617

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LCP1NP_002289.2 EFh 13..79 CDD:238008 17/65 (26%)
SAC6 16..620 CDD:227401 331/614 (54%)
Actin-binding 1 106..379 148/273 (54%)
CH 121..236 CDD:237981 65/114 (57%)
CH 265..370 CDD:278723 55/105 (52%)
Actin-binding 2 380..624 154/251 (61%)
CH 398..501 CDD:214479 73/106 (69%)
CH 519..620 CDD:214479 64/100 (64%)
FimNP_728074.1 EF-hand_7 27..84 CDD:290234 15/56 (27%)
EFh 27..80 CDD:298682 13/52 (25%)
CH 127..237 CDD:278723 62/109 (57%)
CH 271..370 CDD:278723 55/105 (52%)
CH 396..497 CDD:214479 72/105 (69%)
CH 517..619 CDD:214479 65/102 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152962
Domainoid 1 1.000 144 1.000 Domainoid score I4611
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H80174
Inparanoid 1 1.050 613 1.000 Inparanoid score I913
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54335
OrthoDB 1 1.010 - - D138895at33208
OrthoFinder 1 1.000 - - FOG0000930
OrthoInspector 1 1.000 - - otm40640
orthoMCL 1 0.900 - - OOG6_101115
Panther 1 1.100 - - LDO PTHR19961
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2112
SonicParanoid 1 1.000 - - X500
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.900

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