DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7248 and CG43896

DIOPT Version :9

Sequence 1:	NP_648530.1	Gene:	CG7248 / 39356	FlyBaseID:	FBgn0036229	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_001261732.1	Gene:	CG43896 / 39360	FlyBaseID:	FBgn0264488	Length:	2113	Species:	Drosophila melanogaster

Alignment Length:	923	Identity:	208/923 - (22%)
Similarity:	312/923 - (33%)	Gaps:	260/923 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SFSKRNSHECVVSSQQNST----YCESLSNG-FYEYPYNCSAYITCYDSCADLEYCPDGKLFNSP 101
            ||.......|:..:  |||    .|.:.:|| |.|...||.:|..|.:..|.|:.||.|..||:.
  Fly   131 SFFNETLAACIPDA--NSTCWQNLCINKTNGVFVENEANCGSYYVCSNGEATLQTCPQGSFFNTS 193

  Fly   102 LQIC-----------------DTPGAV---------------------------------DCEPL 116
            :..|                 |...||                                 .|.|.
  Fly   194 VAACTVDQGNSQCWVNYCIGQDDGSAVADKSNCSLFYVCSNNTATAQECPEGSYFESNNWGCVPG 258

  Fly   117 PYPTPSP----------------TESPPENPCLGTRNNTLLPSAENCNEFYLCVNDQSKVYRCPG 165
            ...|.||                ||.|....|...:|...:|..|||.::::|::.......|..
  Fly   259 TCTTESPCDDSTTTTTESCAEETTEPPASCDCGDIKNADFIPDEENCRKYFICIDGVLVAADCGK 323

  Fly   166 EMLFNPDLNICD-DKDNVWCYGDRTTPDPLDTTTPAEESFTKCEDQEKGTFFPDPENCQQYYYCW 229
            ..:||.:|::|: |.||..|..|                   |.|.|...   ||::|.:|:.|.
  Fly   324 GNVFNANLSVCEVDADNTCCVAD-------------------CTDGEAKV---DPQDCTKYFKCQ 366

  Fly   230 GNKSYTILPCPVDNWFNPISGNCGPDIAPDACRETTPTSTPTIDTSSSTTVAPTST--EDSVGNP 292
            .. .:|.:.|...::||.....|..|: .:.|          ||..|::|..||::  |.|..:.
  Fly   367 SG-DWTSVSCDSGSYFNETLNCCQVDV-NNVC----------IDAKSNSTQIPTTSTVETSSVDK 419

  Fly   293 CADQELGASFPIKSDCQSYLLCLNNGESTTAKCPSNAWFDPKTGDC---GPNVSPTACLESFETT 354
            |..::..||   ..:|.:|..|: :|:.....||:|.:||...|.|   ..||.|       |..
  Fly   420 CNAKDPPAS---GKNCWTYQHCI-SGQWEDGTCPNNTYFDASVGICREDTENVCP-------ENR 473

  Fly   355 TTAVTTQAPKDPCADQ---ELGTSYPLVTNCQQYILCMGNGESTVANCIYNSWFDPQTGNCGPDV 416
            ::....:...:.|..:   ..||.....|:|.:|::| .||:.....|...:.|...:|.|.||.
  Fly   474 SSGSRQKRSVEDCTCEGGIAQGTIIGHSTDCDKYLIC-ENGQLVEGVCGVGNVFQKSSGICVPDT 537

  Fly   417 SPT--AC--KESGVTTASPTTTSQATSPLTTPSPTWSTLPTANT-----------------EETT 460
            ..|  .|  |.:|...|.||   ..||.||    .|:.|.|.:|                 ....
  Fly   538 KATCWVCSNKPNGYQMADPT---DCTSYLT----CWNGLATKHTCGSGEWYNGDGNCVIDVNAKC 595

  Fly   461 TNPPDIVGICS-GESDGYYATYPEVCNKYILCASPVPIAFYCPESLFFNEALQRC---VEWESSD 521
            .||      || |..:   ..:| :|..|..|...||....|.....|:.|..:|   ||..:.:
  Fly   596 INP------CSCGNGN---VAHP-ICTNYFQCTDGVPQVKQCVVGEAFDSATGQCSTTVECSAKN 650

  Fly   522 CSNGETTTSSP-------------------------GFTT--------PSPDTQ--ICSNSTGLN 551
            |:.....|:.|                         |::.        ||||..  || ||..::
  Fly   651 CATASDGTTYPVAGETGQFYVCLSNEATIQPCPVNTGYSAALGICLDQPSPDCDQTIC-NSAAVD 714

  Fly   552 LPYQEN---CQWYIYCTDENSYMMGICGSEEYFDPWTGKCGF--GVSPEACREIQT--TSPTVTD 609
            ..|..|   ...:..|.|..:|:.. |.:..::|.....|.|  ...|:.|.:...  .||...|
  Fly   715 STYPSNDNDSSTFCLCRDSGAYIQS-CPTGLFYDATDQVCTFSGNCDPQVCNDQSEYFVSPDYED 778

  Fly   610 STE-------GPTTVITP-----STPGSE------PDP------CDGAPEGKLVPYPDDCSKFIQ 650
            ...       .|.||..|     :|...|      |||      |.|..:....|..:....|..
  Fly   779 PNSFCLCRAGEPITVSCPIGYTFNTEELECVLIPLPDPRCCANGCSGKTDFSTFPTIEGTDGFCL 843

  Fly   651 CIQPDPIVYDCREGQEFSAALERCMAPWFANCSIPATTIPPVTIPTTTTTTEKPSPNGICADKAE 715
            |:...|....|.|..::...|..|.|           |....|.|....|.      |||....:
  Fly   844 CVDDVPKYISCPENSQYDLELGACTA-----------TEEETTCPVNACTV------GICESALD 891

  Fly   716 GSLVPYPGNCSKYIACEDPIPVGYACPEGEEFNPIILTCTDPHLAGCNPSALHISPKTESDDL-G 779
            .:..|...:.|.:..|.|..|:...|.:...:|..:..||:|.    :||.:......:.|.: .
  Fly   892 FNTFPVSSDPSGFCYCLDSCPIYETCLDDLVYNEDLKRCTEPE----DPSVVSRCDAEKCDSIPD 952

  Fly   780 FSLWQSLKTIASF 792
            |:.:.|:.....|
  Fly   953 FTPYPSINGTDGF 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7248	NP_648530.1	CBM_14	62..113	CDD:279884	20/101 (20%)
		CBM_14	136..182	CDD:279884	13/46 (28%)
		CBM_14	207..261	CDD:279884	14/53 (26%)
		CBM_14	293..347	CDD:279884	17/56 (30%)
		CBM_14	367..421	CDD:279884	16/58 (28%)
		CBM_14	470..522	CDD:279884	15/55 (27%)
		CBM_14	544..597	CDD:279884	13/57 (23%)
		CBM_14	630..678	CDD:279884	11/47 (23%)
		CBM_14	710..758	CDD:279884	10/47 (21%)
CG43896	NP_001261732.1	CBM_14	96..147	CDD:279884	4/17 (24%)
		CBM_14	153..206	CDD:279884	17/52 (33%)
		CBM_14	211..257	CDD:279884	4/45 (9%)
		CBM_14	298..343	CDD:279884	13/44 (30%)
		CBM_14	354..395	CDD:279884	11/45 (24%)
		CBM_14	427..468	CDD:279884	13/44 (30%)
		ChtBD2	488..535	CDD:214696	12/47 (26%)
		CBM_14	544..593	CDD:279884	14/55 (25%)
		CBM_14	<1320..1361	CDD:279884
		ChtBD2	1627..1675	CDD:214696
		CBM_14	1684..1733	CDD:279884
		ChtBD2	1752..1797	CDD:214696
		CBM_14	1820..1868	CDD:279884
		CBM_14	1896..1939	CDD:279884
		ChtBD2	2046..2091	CDD:214696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472932
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29657at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23301
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950