DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7248 and CG4835

DIOPT Version :9

Sequence 1:	NP_648530.1	Gene:	CG7248 / 39356	FlyBaseID:	FBgn0036229	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_647965.3	Gene:	CG4835 / 38619	FlyBaseID:	FBgn0035607	Length:	1224	Species:	Drosophila melanogaster

Alignment Length:	866	Identity:	302/866 - (34%)
Similarity:	397/866 - (45%)	Gaps:	216/866 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 YCESLSNG-FYEYPYNCSAYITCYDSCADLEYCPDGKLFNSPLQICDTPGAVDCEPLPYPTPSPT 124
            ||.:..:| .:.|||:|.|||.|......|.||.:.|:||..|.|||||...|||.||.|| :.|
  Fly   184 YCRNKEDGSVHYYPYDCQAYINCTYGWPVLNYCIEDKVFNKYLGICDTPDMADCEELPLPT-TTT 247

  Fly   125 ESPP------------------ENPCLGTRNNTLLPSAENCNEFYLCVNDQSKVYRCPGEMLFNP 171
            |.||                  |:.|: .:.|.......||:.:..|.|..:.:..|..:.|||.
  Fly   248 EMPPTSTTEEDVVCGPTPEGIEEDYCV-PKGNGFYEYPYNCSGYLACKNGCTDLDYCQPDKLFNN 311

  Fly   172 DLNICDDKDNVWCYGDRTTPDPLD-TTTPAEESFTKCEDQEKGTFFPDPENCQQYYYCWGNKSYT 235
            .|:|||..|:|.|       |||. .|||             ||               .||..|
  Fly   312 WLHICDTPDSVRC-------DPLPFPTTP-------------GT---------------TNKPTT 341

  Fly   236 ILPCPVDNWFNPISGNCGPDIAPDACRETTPTSTPTIDTSSSTTVAPTSTEDSV----------- 289
                              |.:.......|||::..|:.:..|||...:||.:.:
  Fly   342 ------------------PSVTTTPSITTTPSTPTTLPSDGSTTEIHSSTTEEIVTTTDGLPSDV 388

  Fly   290 -GNPCADQELGASFPIKSDCQSYLLCLNNGESTTAKCPSNAWFDPKTGDCG-------------- 339
             .|.|.|::.|..|....:|..||:|.:| :.....||.|..|:|....|.
  Fly   389 DPNDCKDEKDGTIFAYIGNCSEYLICKDN-QVQMGHCPPNTLFNPDLLVCDEPDDVVCLGDRTTT 452

  Fly   340 --PNVSPTACLES---FETTTTAVTTQAPKDPCADQELGTSYPLVTNCQQYILCMGNGESTVANC 399
              |...||...|.   ..||||..||..|...|..||||.|:....:|.:|.||:|.|:.|:|.|
  Fly   453 PIPTTIPTTTTEKTTPTTTTTTVATTLGPDQLCDGQELGASFSYPDDCSKYYLCLGGGQWTLAPC 517

  Fly   400 IYNSWFDPQTGNCGPDVSPTACKESGVTTASPTTTSQATSP--LTTPSPTWSTLPTANTEETTTN 462
            ||.|:|||.||.|||||:|.|||.|.|||.:.|||::.|:.  .|||..|.:|     ||.|||.
  Fly   518 IYGSYFDPSTGQCGPDVAPDACKPSQVTTTTTTTTTETTTTERNTTPKSTATT-----TERTTTT 577

  Fly   463 PPDIVGICSGESDGYYATYPEVCNKYILCASPVPIAFYCPESLFFNEALQRCV-EWESSDCSNGE 526
            .....|||.|.::.....||..|.|||:|.||:||||:||:..||:..|::|: :|:.|||...:
  Fly   578 VAPKTGICGGRNENENIAYPNNCTKYIVCVSPIPIAFFCPDGTFFSSKLEKCIDDWDESDCEGDQ 642

  Fly   527 -TTTSSPGFTTPSPDTQICSNSTGLNLPYQENCQWYIYCTDENSYMMGICGSEEYFDPWTGKCGF 590
             |||..||:|.|.|:..:|:||:....||.:||||:|.|.|:..|||.:|...||:||.|.|||.
  Fly   643 STTTLEPGYTRPPPEPTMCTNSSRDTFPYPDNCQWFIRCVDDYIYMMDVCNCGEYYDPITEKCGA 707

  Fly   591 GVSPEACREIQTTSPTVTDSTEGPTTVITPSTPGSEPDPCDGAPEGKLVPYPDDCSKFIQCIQPD 655
            .|..:|||...|::   |.:|..|||....:.|..:..|||...:|.||.||:||||:|||.:|.
  Fly   708 DVPSDACRWDYTST---TSTTSEPTTTTAVTRPPPQKGPCDDVEDGALVAYPNDCSKYIQCDRPI 769

  Fly   656 PIVYDCREGQEFSAALERCMAPWFANCSIPATTIP------------------------------ 690
            .:.::|.:|.|||..|.:|:....|||||..|..|
  Fly   770 AVAFECEKGDEFSVELGKCVDASLANCSITTTAKPSESTTTPRDGEGSTTPSEPSTGSSTESSTE 834

  Fly   691 -----------------------------------------------PVTI---PTTTT------ 699
                                                           |.||   |::||
  Fly   835 STTEPSTESTTESTTESTTESTTESSTGQSTETTESSTVLSTDTSESPSTISTPPSSTTMEPGTT 899

  Fly   700 -----TTEKPSPNGICADKAEGSLVPYPGNCSKYIACEDPIPVGYACPEGEEFNPIILTCTDPHL 759
                 |||||: :|||..|.:.||||||.||||||.|:.||||||.||:|.||:|..|||.||.|
  Fly   900 NPEASTTEKPA-DGICEGKTDDSLVPYPRNCSKYIKCQYPIPVGYDCPDGLEFSPTELTCMDPEL 963

  Fly   760 AGCN-----PSALHISPKTES 775
            |||:     |....:|.:..|
  Fly   964 AGCSTKLTTPGLTTLSTEASS 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7248	NP_648530.1	CBM_14	62..113	CDD:279884	22/51 (43%)
		CBM_14	136..182	CDD:279884	14/45 (31%)
		CBM_14	207..261	CDD:279884	6/53 (11%)
		CBM_14	293..347	CDD:279884	18/69 (26%)
		CBM_14	367..421	CDD:279884	29/53 (55%)
		CBM_14	470..522	CDD:279884	23/52 (44%)
		CBM_14	544..597	CDD:279884	25/52 (48%)
		CBM_14	630..678	CDD:279884	22/47 (47%)
		CBM_14	710..758	CDD:279884	31/47 (66%)
CG4835	NP_647965.3	CBM_14	51..103	CDD:279884
		CBM_14	185..237	CDD:279884	22/51 (43%)
		CBM_14	273..322	CDD:279884	15/49 (31%)
		CBM_14	393..444	CDD:279884	15/51 (29%)
		CBM_14	485..539	CDD:279884	29/53 (55%)
		CBM_14	585..638	CDD:279884	23/52 (44%)
		CBM_14	661..714	CDD:279884	25/52 (48%)
		CBM_14	744..796	CDD:279884	23/51 (45%)
		CBM_14	914..962	CDD:279884	31/47 (66%)
		CBM_14	1175..1212	CDD:279884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472914
Domainoid	1	1.000	52	1.000	Domainoid score	I18614
eggNOG	1	0.900	-	-		E1_29YBV
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29657at33392
OrthoFinder	1	1.000	-	-		FOG0014392
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23301
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11800
	8	7.850