DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5883 and Megf10

DIOPT Version :9

Sequence 1:NP_648526.2 Gene:CG5883 / 39352 FlyBaseID:FBgn0036225 Length:339 Species:Drosophila melanogaster
Sequence 2:NP_001001979.1 Gene:Megf10 / 70417 MGIID:2685177 Length:1147 Species:Mus musculus


Alignment Length:410 Identity:91/410 - (22%)
Similarity:122/410 - (29%) Gaps:161/410 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 DICRLFKDGTQLLKPGSC----------SESIICQNFESTPGITCSGSKPYYSKSKGSCQASADT 87
            :.||....|......|:|          .|:.:|.  |...||.|....|.:..:..||...:..
Mouse   322 EACRCVNGGKCYHVSGTCLCEAGFSGELCEARLCP--EGLYGIKCDKRCPCHLDNTHSCHPMSGE 384

  Fly    88 YCDTSKICKGSGTG-YIGDTINCANWYY-------------CDADALLG--------KGT----- 125
             |.    ||...:| |..:|  |:..:|             .|.|::.|        |||     
Mouse   385 -CG----CKPGWSGLYCNET--CSPGFYGEACQQICSCQNGADCDSVTGRCACAPGFKGTDCSTP 442

  Fly   126 CNLGMYFDQVSKSCVYSEDTVC----------AAKYEI-CDV-APVGT-PFRDDANCHKYYTCSS 177
            |.||.|....|..|....|.||          |..:.: |.: .|.|| .|    .|:  .||. 
Mouse   443 CPLGRYGINCSSRCGCKNDAVCSPVDGSCICKAGWHGVDCSIRCPSGTWGF----GCN--LTCQ- 500

  Fly   178 KSLVENTCENGLYYNVATGTCV-------RKKDVICEN-------------------HP------ 210
                   |.||...|...|||.       .|.:..|::                   ||      
Mouse   501 -------CLNGGACNTLDGTCTCAPGWRGAKCEFPCQDGTYGLNCAERCDCSHADGCHPTTGHCR 558

  Fly   211 -LP-------DEVCGNKKLAVRNKFVSDMATCRGYYYCRDLGSGIPDTDPIYQQCDENNFFNQER 267
             ||       |.||...:..         ..|....||::..|..|| |.|. :|.........:
Mouse   559 CLPGWSGVHCDSVCAEGRWG---------PNCSLPCYCKNGASCSPD-DGIC-ECAPGFRGTTCQ 612

  Fly   268 QACMP-----RESQKCDYDRCDGRKDGFEVAEIDGCHH---YIECVDG------RETTPISCEDK 318
            :.|.|     |.||.|  .:|        |.....|||   ..:|:.|      .|..|.....|
Mouse   613 RICSPGFYGHRCSQTC--PQC--------VHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGK 667

  Fly   319 YFDVVTQNCSSTHLVYGACS 338
                   ||:      |.|:
Mouse   668 -------NCA------GVCT 674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5883NP_648526.2 CBM_14 95..146 CDD:279884 20/77 (26%)
CBM_14 154..204 CDD:279884 16/58 (28%)
Megf10NP_001001979.1 Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7 1..857 91/410 (22%)
EMI 32..99 CDD:284877
EGF_CA 281..326 CDD:304395 1/3 (33%)
EGF_CA 542..587 CDD:304395 8/53 (15%)
Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7 945..1147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1147
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D561378at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

Return to query results.
Submit another query.