Protein Alignment Rpt4R and YME1L1

DIOPT Version :10

• Sequence 1: NP_648525.1
• Gene: Rpt4R / 39351
• FlyBaseID: FBgn0036224
• Length: 398
• Species: Drosophila melanogaster
• Sequence 2: NP_647473.1
• Gene: YME1L1 / 10730
• HGNCID: 12843
• Length: 773
• Species: Homo sapiens
• Alignment Length: 413
• Identity: 126/413 - (30%)
• Similarity: 191/413 - (46%)
• Gaps: 74/413 - (17%)

  Fly    14 RVRALTNYRTKLLEHREIE-------------SKLKALRDKYKVVNAEYEKSEDDLKALQSVGQM 65
            |.|.|.:...:|.|.:.|.             |.:::|....|..|.. |..:|..|...:.|.:
Human   214 RTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIP-EAHQDAFKTGFAEGFL 277

  Fly    66 VGEILKQLTPDNFIVKASNGPRYVVGCRRQINKEKLKPGTRVALDVTTL-----------TIMRY 119
            ..:.|.|.|.|:.              ||          ||:.|.|..|           ..:|:
Human   278 KAQALTQKTNDSL--------------RR----------TRLILFVLLLFGIYGLLKNPFLSVRF 318

  Fly   120 -----LPREVDPLVYNMTHEDPGNVNYAEIGGLGQQIRELREVIELPLLNPDIFLRVGISPPKGC 179
                 |...|||:...       ||.:..:.|:.:..:||:||:|. |.||..|..:|...|||.
Human   319 RTTTGLDSAVDPVQMK-------NVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGI 375

  Fly   180 LLYGPPGTGKTLLARAIASQMDANFLKVVSSAIVDKYIGESARLIREMFAYARDHQPCIIFMDEI 244
            ||.|||||||||||||:|.:.|..|.....|...:.::|..|..||.:|..|:.:.||:||:||:
Human   376 LLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDEL 440

  Fly   245 DAIGGRRFSEGTSADREIQRTLMELLNQMDGFDALGQVKMIMATNRPDTLDPALLRPGRLDRKLE 309
            |::||:|..  :......::|:.:||.:||||.....|.:|.|||.|:.||.||:||||.|.::.
Human   441 DSVGGKRIE--SPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVT 503

  Fly   310 IPLPNEVARMDILKIHAEPLNKRGEIDYEAVVKLSDLFNGADLRNICTEAGLFALRCDREFVIQE 374
            :|.|:...|.:|||.:...:.....:|.|.:.:.:..|:||:|.|:..:|.|.|....:|.|..:
Human   504 VPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMK 568

  Fly   375 DFMKAVRKI----------ADNK 387
            :...:..||          .|||
Human   569 ELEFSKDKILMGPERRSVEIDNK 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpt4R	NP_648525.1	PRK03992	13..388	CDD:179699	126/413 (31%)
YME1L1	NP_647473.1	HflB	<332..767	CDD:440233	96/270 (36%)