Protein Alignment byn and Tbx18

DIOPT Version :9

• Sequence 1: NP_524031.2
• Gene: byn / 39349
• FlyBaseID: FBgn0011723
• Length: 697
• Species: Drosophila melanogaster
• Sequence 2: NP_076303.3
• Gene: Tbx18 / 76365
• MGIID: 1923615
• Length: 613
• Species: Mus musculus
• Alignment Length: 580
• Identity: 184/580 - (31%)
• Similarity: 263/580 - (45%)
• Gaps: 139/580 - (23%)

  Fly     1 MTTSHILSAVDPTTGLSGNVSGGGGGGGA------------GGGAGSGSPQHVTHNGHGHGHG-- 51
            :.|.....||: ..|.|.  |||.|..|.            ..||.||..:.........|..
Mouse    41 LATEEAAGAVE-DAGCSR--SGGAGEHGCSEADEEAAAPPPAAGAASGPARSCADAERSCGSRGA 102

  Fly    52 --------LGGVAAVSGGGASVSGNGGHRVVGGA--GSPNELDRNLRISLDDRELWLRFQNLTNE 106
                    |.|.:.::..|.|..|:   .|.|.|  |:|....:..|:.|...|||.||..:..|
Mouse   103 AGSCEDGFLQGASPLASPGGSPKGS---PVPGLARPGTPLPAPQAPRVDLQGAELWKRFHEIGTE 164

  Fly   107 MIVTKNGRRMFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYV--NGEWVPGGKAEVPPSNPIY 169
            ||:||.||||||.:::..|||||...|.:.::.|.:|:.|::||  :.:|:..|.|:.|....:|
Mouse   165 MIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVY 229

  Fly   170 VHPESPNFGAHWMKEPISFAKVKLT-NKTNGNGQIMLNSLHKYEPRVHLVR--VGSEQRHVVTYP 231
            :||:||..|..||::.|||.|:||| |:.:..|.|:|:|:|||:||||::|  .|.:...:...|
Mouse   230 IHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVP 294

  Fly   232 ---------FPETQFIAVTAYQNEEVTSLKIKYNPFAKAFLDAKE---------------RPD-- 270
                     ||||.|..||||||:::|.|||..|||||.|.|:..               ||.
Mouse   295 SGEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRMGLEALVESYAFWRPSLR 359

  Fly   271 TLYPHDTHYGWLIP--PPTHYTAAAA-------AVAAPPPLSIAQSHGLVASC--------PSVS 318
            ||...|      ||  |....|:::|       ||.|..|..::.|     ||        |:.|
Mouse   360 TLTFED------IPGIPKQGNTSSSALLQGTGNAVPATHPHLLSGS-----SCSSPAFHLGPNTS 413

  Fly   319 SAESVGPSSGGSCDRYGRSLS--SRSVAPTRTTPYSRPRVVSGSGSNGSAGNASSTSPQPPSAPQ 381
            ...|:.|:...:|.|.|.:|:  |.|:|.|    |||            ..|.||.:..|   |:
Mouse   414 QLCSLAPADYSACARSGLALNRYSTSLAET----YSR------------LTNQSSETFAP---PR 459

  Fly   382 TPTSLHSTSTGSVSTSVSSSSGGGIGSAPSTGCFSSSYAQSGFMS-----VDASPTASVFSYPSS 441
            ||:.:..:|..||:.|:..:.|... |.|.|   |.|...|| ||     :..||:.:.|:...:
Mouse   460 TPSYVSVSSNPSVNMSMGGTDGDTF-SCPQT---SLSMQISG-MSPQLQYIMPSPSGNAFAANQT 519

  Fly   442 WQSNGNYWNATSVPGPMPMNVCS--GRNISSHNSP----SP---TNGSPSYTTSSPSYTI 492
            .||:   :|...:..|     |:  |.|.|:  ||    ||   .:...|:..||||.|:
Mouse   520 HQSS---YNTFRLHSP-----CALYGYNFST--SPKLAASPEKIVSSQGSFLGSSPSGTM 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
byn	NP_524031.2	TBOX	86..268	CDD:238106	85/210 (40%)
Tbx18	NP_076303.3	Engrailed homology 1 repressor. /evidence=ECO:0000305|PubMed:17584735	18..28
		Nuclear localization signal. /evidence=ECO:0000305|PubMed:17584735	36..40
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..94		14/55 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..145		8/33 (24%)
		TBOX	145..340	CDD:238106	85/194 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810