Protein Alignment byn and TBX3

DIOPT Version :10

• Sequence 1: NP_524031.2
• Gene: byn / 39349
• FlyBaseID: FBgn0011723
• Length: 697
• Species: Drosophila melanogaster
• Sequence 2: NP_057653.3
• Gene: TBX3 / 6926
• HGNCID: 11602
• Length: 743
• Species: Homo sapiens
• Alignment Length: 720
• Identity: 190/720 - (26%)
• Similarity: 281/720 - (39%)
• Gaps: 191/720 - (26%)

  Fly    54 GVAAVSGGGASVSGNGGHRVVGGA--GSP-------------------NELDRNLRISLDDRELW 97
            |.||:|..|| ::.....::||.|  |.|                   .|::.:.::.|:.:|||
Human    50 GAAALSLPGA-LAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELW 113

  Fly    98 LRFQNLTNEMIVTKNGRRMFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYVNGEWVPGGKAEV 162
            .:|.....||::||:||||||..|:..||||..|.|.:|::.:..|..|:|:.|..|:..|||:.
Human   114 DQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADP 178

  Fly   163 PPSNPIYVHPESPNFGAHWMKEPISFAKVKLTNKTN-----------------GN----GQIMLN 206
            .....:|:||:||..|..||.:.::|.|:||||..:                 ||    .|.:||
Human   179 EMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILN 243

  Fly   207 SLHKYEPRVHLVRVG-------SEQRHVVTYPFPETQFIAVTAYQNEEVTSLKIKYNPFAKAFLD 264
            |:|||:||.|:||..       |..|   ||.||||:|||||||||:::|.|||..|||||.|.|
Human   244 SMHKYQPRFHIVRANDILKLPYSTFR---TYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRD 305

  Fly   265 A------KERPDTLYP-------HDTHYGWLIPPPTHYTA-AAAAVAAPPPLSIAQSHGLVASCP 315
            .      |.:..||..       |....|......:...| ...|.|:.|..|...:..|...||
Human   306 TGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCP 370

  Fly   316 S-------VSSAESVGPSSGGSCDRYGRSLSSRSVAPTRT--TP--------YSRPRVVSGSGSN 363
            |       ..|.|..||.   :||. .:..::.|..|.|.  :|        ..|||      .:
Human   371 SEGESDAEAESKEEHGPE---ACDA-AKISTTTSEEPCRDKGSPAVKAHLFAAERPR------DS 425

  Fly   364 GSAGNASSTSPQPPSAPQTPTSLHSTSTGSVSTSVSSSSGGGIGSAPSTGCFSSSYAQSGFMSVD 428
            |....||            |.|.||.:|       .|||..|:|:...........|.:......
Human   426 GRLDKAS------------PDSRHSPAT-------ISSSTRGLGAEERRSPVREGTAPAKVEEAR 471

  Fly   429 ASPTASVFSYPSSWQSNGNYWNATSVPGPMPMNVCSGRNISSH--NSPSPTNGSPSYTTSSPSYT 491
            |.|....|: |.:.|::.                     .::|  ..|.|..|..........:.
Human   472 ALPGKEAFA-PLTVQTDA---------------------AAAHLAQGPLPGLGFAPGLAGQQFFN 514

  Fly   492 IHHLTPHSHQYNM--AQTDIYGTGVG------VGGGAGTTGSPQAAYGAAA-------------- 534
            .|.|..|..|:.|  |.:.:...|:|      .|...|.:|....|..:||
Human   515 GHPLFLHPSQFAMGGAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLP 579

  Fly   535 -HQVYHPTPT-----SPTHQLYTNAVLNAPSALSYSASGWHNGSGAEYGLYQNAAAAYYQPEYIP 593
             |...|...:     ||...|:       |...:|.|:.....|.|       |:::.::..::.
Human   580 FHLQQHVLASQGLAMSPFGSLF-------PYPYTYMAAAAAASSAA-------ASSSVHRHPFLN 630

  Fly   594 L-----EIGYATHPLEPVDVS------KTLDDPQAAMYKPSDEQGSVITLECASSSLKSSHDIKI 647
            |     .:.|:.:.: ||.|.      .|.....||...|.|.:.:.:....||.::.|..::..
Human   631 LNTMRPRLRYSPYSI-PVPVPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSGSELNS 694

  Fly   648 ESSSL 652
            .||:|
Human   695 RSSTL 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
byn	NP_524031.2	T-box_TBXT_TBX19-like	87..264	CDD:410318	86/204 (42%)
TBX3	NP_057653.3	T-box_TBX2_3-like	104..305	CDD:410314	86/203 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..342		8/40 (20%)
		TBX	323..403	CDD:432659	18/83 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..465		32/135 (24%)
		Transcription repression	544..695		30/165 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	688..707		4/12 (33%)