DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment byn and TBX3

DIOPT Version :9

Sequence 1:	NP_524031.2	Gene:	byn / 39349	FlyBaseID:	FBgn0011723	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_057653.3	Gene:	TBX3 / 6926	HGNCID:	11602	Length:	743	Species:	Homo sapiens

Alignment Length:	720	Identity:	190/720 - (26%)
Similarity:	281/720 - (39%)	Gaps:	191/720 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GVAAVSGGGASVSGNGGHRVVGGA--GSP-------------------NELDRNLRISLDDRELW 97
            |.||:|..|| ::.....::||.|  |.|                   .|::.:.::.|:.:|||
Human    50 GAAALSLPGA-LAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELW 113

  Fly    98 LRFQNLTNEMIVTKNGRRMFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYVNGEWVPGGKAEV 162
            .:|.....||::||:||||||..|:..||||..|.|.:|::.:..|..|:|:.|..|:..|||:.
Human   114 DQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADP 178

  Fly   163 PPSNPIYVHPESPNFGAHWMKEPISFAKVKLTNKTN-----------------GN----GQIMLN 206
            .....:|:||:||..|..||.:.::|.|:||||..:                 ||    .|.:||
Human   179 EMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILN 243

  Fly   207 SLHKYEPRVHLVRVG-------SEQRHVVTYPFPETQFIAVTAYQNEEVTSLKIKYNPFAKAFLD 264
            |:|||:||.|:||..       |..|   ||.||||:|||||||||:::|.|||..|||||.|.|
Human   244 SMHKYQPRFHIVRANDILKLPYSTFR---TYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRD 305

  Fly   265 A------KERPDTLYP-------HDTHYGWLIPPPTHYTA-AAAAVAAPPPLSIAQSHGLVASCP 315
            .      |.:..||..       |....|......:...| ...|.|:.|..|...:..|...||
Human   306 TGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCP 370

  Fly   316 S-------VSSAESVGPSSGGSCDRYGRSLSSRSVAPTRT--TP--------YSRPRVVSGSGSN 363
            |       ..|.|..||.   :||. .:..::.|..|.|.  :|        ..|||      .:
Human   371 SEGESDAEAESKEEHGPE---ACDA-AKISTTTSEEPCRDKGSPAVKAHLFAAERPR------DS 425

  Fly   364 GSAGNASSTSPQPPSAPQTPTSLHSTSTGSVSTSVSSSSGGGIGSAPSTGCFSSSYAQSGFMSVD 428
            |....||            |.|.||.:|       .|||..|:|:...........|.:......
Human   426 GRLDKAS------------PDSRHSPAT-------ISSSTRGLGAEERRSPVREGTAPAKVEEAR 471

  Fly   429 ASPTASVFSYPSSWQSNGNYWNATSVPGPMPMNVCSGRNISSH--NSPSPTNGSPSYTTSSPSYT 491
            |.|....|: |.:.|::.                     .::|  ..|.|..|..........:.
Human   472 ALPGKEAFA-PLTVQTDA---------------------AAAHLAQGPLPGLGFAPGLAGQQFFN 514

  Fly   492 IHHLTPHSHQYNM--AQTDIYGTGVG------VGGGAGTTGSPQAAYGAAA-------------- 534
            .|.|..|..|:.|  |.:.:...|:|      .|...|.:|....|..:||
Human   515 GHPLFLHPSQFAMGGAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLP 579

  Fly   535 -HQVYHPTPT-----SPTHQLYTNAVLNAPSALSYSASGWHNGSGAEYGLYQNAAAAYYQPEYIP 593
             |...|...:     ||...|:       |...:|.|:.....|.|       |:::.::..::.
Human   580 FHLQQHVLASQGLAMSPFGSLF-------PYPYTYMAAAAAASSAA-------ASSSVHRHPFLN 630

  Fly   594 L-----EIGYATHPLEPVDVS------KTLDDPQAAMYKPSDEQGSVITLECASSSLKSSHDIKI 647
            |     .:.|:.:.: ||.|.      .|.....||...|.|.:.:.:....||.::.|..::..
Human   631 LNTMRPRLRYSPYSI-PVPVPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSGSELNS 694

  Fly   648 ESSSL 652
            .||:|
Human   695 RSSTL 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
byn	NP_524031.2	TBOX	86..268	CDD:238106	88/215 (41%)
TBX3	NP_057653.3	TBOX	104..307	CDD:238106	87/205 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..342		8/40 (20%)
		TBX	323..411	CDD:204975	20/91 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..465		32/136 (24%)
		Transcription repression	544..695		30/165 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..707		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810