DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment byn and TBX15

DIOPT Version :9

Sequence 1:	NP_524031.2	Gene:	byn / 39349	FlyBaseID:	FBgn0011723	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	XP_005271218.1	Gene:	TBX15 / 6913	HGNCID:	11594	Length:	635	Species:	Homo sapiens

Alignment Length:	620	Identity:	170/620 - (27%)
Similarity:	253/620 - (40%)	Gaps:	145/620 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VVGGAGSP-----NELDRNLRISLDDRELWLRFQNLTNEMIVTKNGRRMFPVVKISASGLDPAAM 132
            :..||..|     :.:: .:::.|...:||.||.::..|||:||.||||||.:::..:||||...
Human    95 LASGAAGPVPAAMSSME-EIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQ 158

  Fly   133 YTVLLEFVQIDSHRWKYV--NGEWVPGGKAEVPPSNPIYVHPESPNFGAHWMKEPISFAKVKLT- 194
            |.:.::.|.:|:.|::||  :.:|:..|.|:.|....:|:||:|...|..||::.:||.|:|||
Human   159 YYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTN 223

  Fly   195 NKTNGNGQIMLNSLHKYEPRVHLVR--------------VGSEQRHVVTYPFPETQFIAVTAYQN 245
            |:.:..|.|:|:|:|||:||||::|              ||.   .|.|:.||||.|..||||||
Human   224 NELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGD---GVKTFNFPETVFTTVTAYQN 285

  Fly   246 EEVTSLKIKYNPFAKAFLDAKERPDTLYPHDTHYGWLIPPPTHYTAAAAAVAAPPPLSIAQSHGL 310
            :::|.|||..|||||.|.|:......|......|.:..||....|............|...|.|.
Human   286 QQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQASKKTSQGY 350

  Fly   311 VASCPSVSSAESVGPSSGGSCDRYGRSLSSRSVAPTRTTPYSRPRVVSGSGSNGSAGNASSTSPQ 375
            ..:..|         |...:.:.|.|                |..::...||.|::...|||...
Human   351 TVNQHS---------SETDAIELYER----------------RVWLMERRGSTGTSPTTSSTGTP 390

  Fly   376 PPSAPQTPTSLHSTSTGSVSTSVSSSSGGGIGSAPST---GCFSSSYAQ---SGFMSVDASPTAS 434
            .|||     |.|..|        .|.|......||:|   ||..|....   |.:.....|..|:
Human   391 SPSA-----SSHLLS--------PSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAA 442

  Fly   435 VFSYPSSWQSNGNYWNATSVPGPMPMNVCSGRNISSHNSPSPTNGSPSYTTSSPSYTIHHLTPHS 499
            :.|||....|..|...:.:.....|     ........:||..:|.|              ||.|
Human   443 LQSYPGLSDSGYNRLQSGTTSATQP-----SETFMPQRTPSLISGIP--------------TPPS 488

  Fly   500 HQYNMAQTDIYGTGVG------------VGGGAGTTGSP---------QAAYGA-AAHQVY---- 538
            ...| ::.:.||..:|            .|..|.::.||         |::|.| :.|..|
Human   489 LPGN-SKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYG 552

  Fly   539 HPTPTSPTHQLYTNAVLNAPSALSYS-----ASGWHNGSGAEYGLYQNAAAAYYQPEYIPLEIGY 598
            :..||||       .:..:|..||.|     .|...||             |:.:.:|:|..:.:
Human   553 YNFPTSP-------RLAASPEKLSASQSTLLCSSPSNG-------------AFGERQYLPSGMEH 597

  Fly   599 ATHPLEP----VDVSKTLDDPQAAMYKPSDEQGSV 629
            :.|.:.|    ...:.|.|..|......|..|.||
Human   598 SMHMISPSPNNQQATNTCDGRQYGAVPGSSSQMSV 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
byn	NP_524031.2	TBOX	86..268	CDD:238106	82/198 (41%)
TBX15	XP_005271218.1	TBOX	113..308	CDD:238106	82/197 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810