Protein Alignment byn and TBX2

DIOPT Version :9

• Sequence 1: NP_524031.2
• Gene: byn / 39349
• FlyBaseID: FBgn0011723
• Length: 697
• Species: Drosophila melanogaster
• Sequence 2: NP_005985.3
• Gene: TBX2 / 6909
• HGNCID: 11597
• Length: 712
• Species: Homo sapiens
• Alignment Length: 702
• Identity: 196/702 - (27%)
• Similarity: 276/702 - (39%)
• Gaps: 170/702 - (24%)

  Fly    51 GLGGVAAVSGGGASVSGNGGHRVVGGAGSP-------------NELDRNLRISLDDRELWLRFQN 102
            ||.|.||.:...|:.:..|.|....|...|             :|::.:.:::|:.:|||.:|..
Human    56 GLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHK 120

  Fly   103 LTNEMIVTKNGRRMFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYVNGEWVPGGKAEVPPSNP 167
            |..||::||:||||||..|:..||||..|.|.:|::.|..|..|:|:.|..|:..|||:......
Human   121 LGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 185

  Fly   168 IYVHPESPNFGAHWMKEPISFAKVKLTNK-TNGNGQIMLNSLHKYEPRVHLVRVG-------SEQ 224
            :|:||:||..|..||.:|::|.|:||||. ::.:|..:|||:|||:||.|:||..       |..
Human   186 MYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTF 250

  Fly   225 RHVVTYPFPETQFIAVTAYQNEEVTSLKIKYNPFAKAFLDA-----KERPDTLYP----HDTH-- 278
            |   ||.||||.|||||||||:::|.|||..|||||.|.|.     ::|.....|    ::.|
Human   251 R---TYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCK 312

  Fly   279 ---------YGWLIPPPTHYTAAAAAVAAPPPLSIAQSHGLVASCPSVSSAESVGPSSGGSCDRY 334
                     .....|||......:.. |||.||.:.::.....||.:.|..|....|...:....
Human   313 PERDGAESDASSCDPPPAREPPTSPG-AAPSPLRLHRARAEEKSCAADSDPEPERLSEERAGAPL 376

  Fly   335 GRSLSSRSVAPTRTTPYSRPR---------VVSGSGSNGSAGNASSTSPQPPSAPQTPTSLHSTS 390
            |||.:..|.:|||.|...|.|         ..:.||.:|..| ..|...:...|.:........:
Human   377 GRSPAPDSASPTRLTEPERARERRSPERGKEPAESGGDGPFG-LRSLEKERAEARRKDEGRKEAA 440

  Fly   391 TGS------VSTSVSSSSGGGIGSAPSTGCFSSSYAQSGFMSVDASPTASVFSYPSSWQSNGNYW 449
            .|.      :.....|:|..|.|..|.....|..:.|..|
Human   441 EGKEQGLAPLVVQTDSASPLGAGHLPGLAFSSHLHGQQFF------------------------- 480

  Fly   450 NATSVPGPMPMNVCSGRNISSHNSPSPTNGSPSYTTSSP----SYTIHHLTPHSHQYNMAQTDIY 510
                  ||:.    :|:.:..|         |...|..|    :..:.||.          ..:.
Human   481 ------GPLG----AGQPLFLH---------PGQFTMGPGAFSAMGMGHLL----------ASVA 516

  Fly   511 GTGVGVGGGAGTT--------GSPQAAYGAAAHQVYH-----------PTPT----SPTHQLYTN 552
            |.|.|.|||.||.        |...:|...||...:|           |.||    .|....|..
Human   517 GGGNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMA 581

  Fly   553 AVLNAPSALSYSASGWHNGSGAEYGLYQNAAAAYYQPEYIPLEIGYATHPL--EPVDVSKTLDDP 615
            |...|.|||..:::.            ..||||.......|. :|.|...|  .|..:..|:
Human   582 AAAAAASALPATSAA------------AAAAAAAGSLSRSPF-LGSARPRLRFSPYQIPVTI--- 630

  Fly   616 QAAMYKPSDEQGSVITLECASSSLKSSHDIKIESSSLEHAGER--GTVGGGA 665
                 .||.   |::|...||...|::.....|.|.|.....|  |....||
Human   631 -----PPST---SLLTTGLASEGSKAAGGNSREPSPLPELALRKVGAPSRGA 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
byn	NP_524031.2	TBOX	86..268	CDD:238106	88/194 (45%)
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	87/186 (47%)
		PHA03307	300..>467	CDD:223039	36/168 (21%)
		TBX	305..383	CDD:403708	17/78 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..450		30/138 (22%)
		Repression domain 1 (RD1)	518..601		23/94 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..687		11/38 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810