DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment byn and TBX20

DIOPT Version :9

Sequence 1:	NP_524031.2	Gene:	byn / 39349	FlyBaseID:	FBgn0011723	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_001071121.1	Gene:	TBX20 / 57057	HGNCID:	11598	Length:	447	Species:	Homo sapiens

Alignment Length:	458	Identity:	140/458 - (30%)
Similarity:	202/458 - (44%)	Gaps:	132/458 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 GGAGS-------------------PNELDRNLRISLDDRELWLRFQNLTNEMIVTKNGRRMFPVV 120
            ||:||                   |:|....:..||:.:|||.:|..|..|||:||:||||||.:
Human    69 GGSGSSPSSSSLCTEPLIPTTPIIPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTI 133

  Fly   121 KISASGLDPAAMYTVLLEFVQIDSHRWKYV--NGEWVPGGKAEVPPSNPIYVHPESPNFGAHWMK 183
            ::|.||:||.|.|.||::.|.:|:.|::|.  ...|:..|||:.|....:||||:||..|...:|
Human   134 RVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLK 198

  Fly   184 EPISFAKVKLT-NKTNGNGQIMLNSLHKYEPRVHLVR--------VGSEQRHVVTYPFPETQFIA 239
            :.:||.||||| |:.:.:|.|:|||:|||:||||:::        :..:.....|:.||||.|.|
Human   199 QMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTA 263

  Fly   240 VTAYQNEEVTSLKIKYNPFAKAFLDAKERPDTLYPHDTHYGWLIPPPTHYTAAAAAVAAPPPLSI 304
            ||||||:.:|.|||..|||||.|.|:....|                         :......|:
Human   264 VTAYQNQLITKLKIDSNPFAKGFRDSSRLTD-------------------------IERESVESL 303

  Fly   305 AQSHGLVASCPSVSSAESVGPSSGGSCDRYGRSLSSRSVAPTRTTPYSRPRVVSGSGSNGSAGNA 369
            .|.|.                        |.||       |.||.          .|.....|:.
Human   304 IQKHS------------------------YARS-------PIRTY----------GGEEDVLGDE 327

  Fly   370 SSTSPQPPSAPQTPTSLHSTSTGSVSTSVSSSSGGGIGSAPSTGCFSSSYAQSGFMSVDASPTAS 434
            |.|:|...||..|..:|      |:|:.|||||     |.|     ...:.||  ::...:.|||
Human   328 SQTTPNRGSAFTTSDNL------SLSSWVSSSS-----SFP-----GFQHPQS--LTALGTSTAS 374

  Fly   435 VFSYPSSWQSNGNYWNATSVPGPMPMNVCSGRNISSHNSPSPTNGSPSYTTSSPSYTIHHLTPHS 499
            :               ||.:|.|:..::.....:....:||..  :.|...|.|::...|: |..
Human   375 I---------------ATPIPHPIQGSLPPYSRLGMPLTPSAI--ASSMQGSGPTFPSFHM-PRY 421

  Fly   500 HQY 502
            |.|
Human   422 HHY 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
byn	NP_524031.2	TBOX	86..268	CDD:238106	88/192 (46%)
TBX20	NP_001071121.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..81		4/11 (36%)
		T-box	102..288	CDD:307177	87/185 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..340		8/33 (24%)
		DUF853	<357..>409	CDD:331106	13/75 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810